| Project/Area Number |
20591999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
SHIMIZU Takeshi Shiga University of Medical Science, 医学部, 教授 (00206202)
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| Co-Investigator(Kenkyū-buntansha) |
SENO Satoshi 滋賀医科大学, 医学部, 助教 (90378464)
SHIBAYAMA Masayuki 滋賀医科大学, 医学部, 助教 (20402711)
HOSHI Eriko 滋賀医科大学, 医学部, 助教 (20467385)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 鼻科学 / リポキシン / 慢性副鼻腔炎 / 好酸球性副鼻腔炎 / 鼻茸 / アレルギー性鼻炎 / IL-8 / リポキシン受容体 / 鼻粘膜 / VEGF / プロスタグランディンE2 / TNFα |
|---|
| Research Abstract |
To elucidate the inhibitory role of lipoxin A4 in upper airway inflammation, we examined the concentration of lipoxin A4 in nasal secretion, and tissue localization of ALX/FPRL-1 receptor in nasal mucosa. In vitro effects of lipoxin A4 on IL-8 secretion from cultured human airway epithelial cells were also examined.
Significant concentrations of lipoxin A4 were found in nasal secretion from patients with allergic rhinitis and chronic rhinosinusitis. ALX/FPRL-1 receptor was detected in epithelial cells, submucosal gland cells and infiltrating cells in nasal mucosa. Increased expression of ALX/FPRL-1 receptor mRNA was found in nasal polyp, compared with nasal mucosa of inferior turbinate. Lipoxin A4 significantly inhibited TNF-alpha-induced IL-8 secretion from cultured human normal bronchial epithelial cells.
These results indicate that lipoxin A4 may be an important inhibitory mediator in the pathogenesis of upper airway inflammation.
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