| Project/Area Number |
20592000
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
|
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| Research Institution | Okayama University |
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Principal Investigator |
ONODA Tomoo Okayama University, 岡山大学病院, 助教 (20420482)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
OKANO Mitsuhiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60304359)
|
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Norihiko 千葉大学, 医学部附属病院・アレルギー膠原病内科, 講師 (20375653)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 花粉症 / マウス / 網羅的解析 / 顎下リンパ節 / IL-5 / IL-13 / スギ花粉発症 / リンパ節 / 感作 / 発症 / IgE / 好酸球 / くしゃみ / スギ花粉症 / サイトカイン / マイクロアレイ / 頸部リンパ節 / Th2 / 不応答 / 共抑制分子 / BTLA / IFN-γ |
|---|
| Research Abstract |
We sought to determine the molecules associated with the pathogenesis of Japanese cedar pollinoisis in mouse. Experiment using KO mice showed that BLTA selectively suppressed Cry j 1-specific Th1 response in this model. Microarray analysis revealed that amounts of mRNAs for Th2 cytokines including IL-5 and IL-13 were significantly higher in submandibular lymph node from responder BALB/c mice as compared with non-responder C57BL/6 mice. On the other hand, removal of submandibular lymph node had little effect on sensitization and onset of Japanese cedar pollinosis in this model.
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