Identification of markers for overexpression of EGFR in head and neck cancer using genomics and proteomics
| Project/Area Number |
20592008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University |
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Principal Investigator |
HOMMA Akihiro Hokkaido University, 大学院・医学研究科, 准教授 (30312359)
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| Co-Investigator(Kenkyū-buntansha) |
HATAKEYAMA Hiromitsu 北海道大学, 病院, 助教 (10455652)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 頭頸部癌 / EGFR / ゲノム / プロテオーム解析 |
|---|
| Research Abstract |
Thirty-eight types of mutation were found in 35 cell lines. Some of them were related with auto-activation of EGFR pathways. Among them, PI3KCA is a key signaling molecular connecting between EGFR and Akt pathway. Mutation in PI3KCA caused protein structural differences in poket-like portion which associated with protein-protein interaction.
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Report
(4 results)
Research Products
(44 results)
