Identification of markers for overexpression of EGFR in head and neck cancer using genomics and proteomics

• Project/Area Number: 20592008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: HOMMA Akihiro Hokkaido University, 大学院・医学研究科, 准教授 (30312359)
• Co-Investigator(Kenkyū-buntansha): HATAKEYAMA Hiromitsu 北海道大学, 病院, 助教 (10455652)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 頭頸部癌 / EGFR / ゲノム / プロテオーム解析

Research Abstract

Thirty-eight types of mutation were found in 35 cell lines. Some of them were related with auto-activation of EGFR pathways. Among them, PI3KCA is a key signaling molecular connecting between EGFR and Akt pathway. Mutation in PI3KCA caused protein structural differences in poket-like portion which associated with protein-protein interaction.

Research Products

• [Journal Article] Superselective high-dose cisplatin infusion with concomitant radiotherapy in patients with advanced cancer of the nasal cavity and paranasal sinuses : a single institution experience. (2010)
  • Author(s): Homma A
  • Journal Title: Cancer 115 Pages: 4705-14
  • Peer Reviewed
• [Journal Article] Phase I/II study of s-1 plus cisplatin combination chemotherapy in patients with advanced/recurrent head and neck cancer. (2010)
  • Author(s): Fujii M, Tomita K, Nishijima W, Tsukuda M, Hasegawa Y, Homma A, Tomita T, et al
  • Journal Title: Jpn J Clin Oncol 40 Pages: 214-221
  • Peer Reviewed
• [Journal Article] Importance of comorbidity in hypopharyngeal cancer. (2010)
  • Author(s): Homma A
  • Journal Title: Head Neck 32 Pages: 148-53
  • Peer Reviewed
• [Journal Article] Cesium implant for tongue carcinoma with a thickness of 1.5 cm or more : cases successfully treated with a Modified Manchester System. (2010)
  • Author(s): Nishioka T, Fujino M, Homma A, et al
  • Journal Title: Yonsei Med J 51 Pages: 557-61
  • Peer Reviewed
• [Journal Article] Salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. (2010)
  • Author(s): Taki S, Homma A, Oridate N, et al
  • Journal Title: Eur Arch Otorhinolaryngol 267 Pages: 1765-9
  • Peer Reviewed
• [Journal Article] Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. (2010)
  • Author(s): Hatakeyama H, et al
  • Journal Title: PLoS One 13
  • Peer Reviewed
• [Journal Article] Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. (2010)
  • Author(s): Chung CH, Aulino J, Muldowney NJ, Hatakeyama H, et al
  • Journal Title: Ann Oncol 21 Pages: 864-70
  • Peer Reviewed
• [Journal Article] Importance of comorbidity in hypopharyngeal cancer. (2010)
  • Author(s): Homma A
  • Journal Title: Head Neck Volume: 32 Pages: 148-53
  • Peer Reviewed
• [Journal Article] Cesium implant for tongue carcinoma with a thickness of 1.5cm or more: cases successfully treated with a Modified Manchester System. (2010)
  • Author(s): Nishioka T
  • Journal Title: Yonsei Med J Volume: 51 Pages: 557-61
  • Peer Reviewed
• [Journal Article] Salvage surgery for local recurrence after chemoradiotherapy or radiotherapy in hypopharyngeal cancer patients. (2010)
  • Author(s): Taki S
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 267 Pages: 1765-9
  • Peer Reviewed
• [Journal Article] Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. (2010)
  • Author(s): Hatakeyama H
  • Journal Title: PLoS One Volume: 13
  • Peer Reviewed
• [Journal Article] Importance of comorbidity in hypopharyngeal cancer (2010)
  • Author(s): Homma A
  • Journal Title: Head Neck 32 Pages: 148-153
  • Peer Reviewed
• [Journal Article] Phase I/II study of s-1 plus cisplatin combination chemotherapy in patients with advanced/recurrent head and neck cancer (2010)
  • Author(s): Fujii M
  • Journal Title: Jpn J Clin Oncol 40 Pages: 214-221
  • Peer Reviewed
• [Journal Article] I p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma. (2009)
  • Author(s): Oridate N, Homma A, Suzuki S, et al
  • Journal Title: Auris Nasus Larynx 36 Pages: 57-63
  • Peer Reviewed
• [Journal Article] p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma. (2009)
  • Author(s): Oridate N, Homma A, et al
  • Journal Title: Arch Otolaryngol Head Neck Surg 135 Pages: 363-368
  • Peer Reviewed
• [Journal Article] Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer : does the standardized uptake value predict treatment outcome? (2009)
  • Author(s): Suzuki K, Nishioka T, Homma A, et al
  • Journal Title: Jpn J Radiol 135 Pages: 237-242
  • Peer Reviewed
• [Journal Article] p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma. (2009)
  • Author(s): Oridate N
  • Journal Title: Arch Otolaryngol Head Neck Surg. 135 Pages: 363-368
  • Peer Reviewed
• [Journal Article] Value of fluorodeoxyglucose positron emission tomography before radiotherapy for head and neck cancer : does the standardized uptake value predict treatment outcome? (2009)
  • Author(s): Suzuki K
  • Journal Title: Jpn J Radiol 135 Pages: 237-242
  • Peer Reviewed
• [Journal Article] p53 expression in concurrent chemoradiotherapy with docetaxel for head and neck squamous cell carcinoma (2009)
  • Author(s): Oridate N
  • Journal Title: Auris Nasus Larynx 36 Pages: 57-63
  • Peer Reviewed
• [Journal Article] Intra-arterial chemotherapy for head and neck cancer : experiences from three continents. (2008)
  • Author(s): Robbins KT, Homma A
  • Journal Title: Surg Oncol Clin N Am 17 Pages: 919-933
  • Peer Reviewed
• [Journal Article] Computer image-guided surgery for total maxillectomy (2008)
  • Author(s): Homma A, et al
  • Journal Title: Eur Arch Otorhinolaryngol 265 Pages: 1521-1526
  • Peer Reviewed
• [Journal Article] Intra-arterial chemotherapy for head and neck cancer : experiences from three continents (2008)
  • Author(s): Robbins KT
  • Journal Title: Surg Oncol Clin N Am 17 Pages: 919-933
• [Journal Article] Computer image-guided surgery for total maxillectomy (2008)
  • Author(s): Homma A
  • Journal Title: Eur Arch Otorhinolaryngol 265 Pages: 1521-1526
  • Peer Reviewed
• [Presentation] パネルディスカッション-鼻副鼻腔腫瘍治療戦略の新しい可能性を探る-鼻副鼻腔悪性腫瘍に対する超選択的動注療法 (2010)
  • Author(s): 本間明宏
  • Organizer: 第49回日本鼻科学会総会・学術講演会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2010-08-28
• [Presentation] パネルディスカッション-鼻副鼻腔腫瘍治療戦略の新しい可能性を探る-.鼻副鼻腔悪性腫瘍に対する超選択的動注療法. (2010)
  • Author(s): 本間明宏
  • Organizer: 第49回日本鼻科学会総会・学術講演会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2010-08-28
• [Presentation] 臨床教育講演「新しいがん治療と機能温存」.超選択的動注化学療法と放射線の同時併用療法 (2010)
  • Author(s): 本間明宏
  • Organizer: 第72回耳鼻咽喉科臨床学会
  • Place of Presentation: 倉敷市芸文館(倉敷市)
  • Year and Date: 2010-07-02
• [Presentation] 臨床教育講演「新しいがん治療と機能温存」.超選択的動注化学療法と放射線の同時併用療法. (2010)
  • Author(s): 本間明宏
  • Organizer: 第72回耳鼻咽喉科臨床学会
  • Place of Presentation: 倉敷市芸文館(倉敷市)
  • Year and Date: 2010-07-02
• [Presentation] Concurrent Superselective Intra-Arterial Cisplatin Infusion with Concomitant Radiotherapy for Laryngeal Cancer. (2010)
  • Author(s): 本間明宏
  • Organizer: IFHNOS(第4回国際頭頸部腫瘍学会議)
  • Place of Presentation: ロッテホテル(ソウル)
  • Year and Date: 2010-06-17
• [Presentation] Concurrent Superselective Intra-Arterial Cisplatin Infusion with Concomitant Radiotherapy for Laryngeal Cancer. (2010)
  • Author(s): Homma A
  • Organizer: IFHNOS (第4回国際頭頸部腫瘍学会議)
  • Place of Presentation: ロッテホテル(ソウル)
  • Year and Date: 2010-06-17
• [Presentation] 下咽頭癌-手術可能症例に対する治療-超選択的動注療法 (2010)
  • Author(s): 本間明宏
  • Organizer: 第15回頭頸部癌化学療法研究会
  • Place of Presentation: ホテルセントラーザ博多(福岡市)
  • Year and Date: 2010-03-06
• [Presentation] 化学放射線療法後の救済手術における皮膚切開デザインの工夫 (2010)
  • Author(s): 本間明宏
  • Organizer: 第20回日本頭頸部外科学会総会ならびに学術講演会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-01-28
• [Presentation] The efficacy of superselective intra-arterial infusion for unresectable carcinoma of the paranasal sinuses. (2010)
  • Author(s): 本間明宏
  • Organizer: The American Head and Neck Society 2010 Research Workshop
  • Place of Presentation: ハイアットリージェンシー(アーリントン・米国)
• [Presentation] Multicenter Phase II Study of an Opioid-based Pain Control Program for Head and Neck Cancer Patients Receiving Chemoradiotherapy. (2010)
  • Author(s): 本間明宏
  • Organizer: 35^<th> European Society for Medical Oncology Congress
  • Place of Presentation: フィエラミラノシティ(ミラノ)
• [Presentation] Multicenter Phase II Study of an Opioid-based Pain Control Program for Head and Neck Cancer Patients Receiving Chemoradiotherapy. (2010)
  • Author(s): Homma A
  • Organizer: 35th European Society for Medical Oncology Congress
  • Place of Presentation: フィエラミラノシティ(ミラノ)イタリア
• [Presentation] 下咽頭がんに対する超選択的動注化学療法 (2009)
  • Author(s): 本間明宏
  • Organizer: 第2回喉頭機能温存治療研究会
  • Place of Presentation: 東京コンファレンスセンター(東京都)
  • Year and Date: 2009-11-27
• [Presentation] Rapid superselective cisplatin infusion with concomitant radiotherapy for base of tongue canser.(舌根癌に対する超選択的動沖療法) (2009)
  • Author(s): 本間明宏
  • Organizer: 第1回欧州耳鼻咽喉科学アカデミー会議
  • Place of Presentation: コングレスセンターロゼンガーテン(マンハイム)
  • Year and Date: 2009-06-28
• [Presentation] Insulin-like Growth Factor-I Receptor Inhibitor Sensitizes Head and Neck Cancer Cells to Cetuximab and Methotrexate. (2009)
  • Author(s): Hatakeyama H
  • Organizer: 45th Annual meeting of American Society of Clinical Oncology
  • Place of Presentation: オレンジカウンティコンベンシンセンター(Orlando, Florida)
• [Presentation] Cetuximab sensitivity in head and neck squamous cell carcinoma cell lines based on the HPV status. (2009)
  • Author(s): Hatakeyama H
  • Organizer: 100^<th> Annual meeting of American Association for Cancer Research
  • Place of Presentation: デンバーコンベンションセンター(Denver, Colorado)
• [Presentation] 頭頸部癌に対する超選択的動注療法と照射同時併用療法 (2008)
  • Author(s): 本間明宏
  • Organizer: 第46回日本癌治療学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
  • Year and Date: 2008-10-31
• [Presentation] Importance of Comorbidity in Hypopharyngeal Cancer. (2008)
  • Author(s): 本間明宏
  • Organizer: the 7th International Conference on Head and Neck Cancer
  • Place of Presentation: マリオットホテル(San Francisco)
  • Year and Date: 2008-07-20
• [Presentation] Importance of Comorbidity in Hypopharyngeal Cancer (2008)
  • Author(s): 本間明宏
  • Organizer: the 7th International Conference on Head and Neck Cancer
  • Place of Presentation: マリオットホテル(San Francisco)
  • Year and Date: 2008-07-20
• [Presentation] 鼻前庭原発扁平上皮癌に対する超選択的動注療法と照射の同時併用療法の経験 (2008)
  • Author(s): 本間明宏
  • Organizer: 第70回耳鼻咽喉科臨床学会総会及び学術講演会
  • Place of Presentation: 長崎ブリックホール(長崎市)
  • Year and Date: 2008-06-28
• [Presentation] 下咽頭癌におけるcomorbidity(併存疾患)の予後への影響について (2008)
  • Author(s): 本間明宏
  • Organizer: 第109回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2008-05-17
• [Presentation] 下咽頭癌における comorbidity(併存疾患)の予後への影響について (2008)
  • Author(s): 本間明宏
  • Organizer: 第109回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 大阪国際会議場(大阪市)
  • Year and Date: 2008-05-17