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Analysis of pathogenesis for tonsil-related diseases and basic evidences of usefulness of tonsillectomy

Research Project

Project/Area Number 20592009
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

KISHIBE Kan (2009-2010)  Asahikawa Medical College, 医学部, 助教 (80447101)

坂東 伸幸 (2008)  Asahikawa Medical College, 医学部, 講師 (60312469)

Co-Investigator(Kenkyū-buntansha) BANDOH Nobuyuki  旭川医科大学, 医学部, 講師 (60312469)
TAKAHARA Miki  旭川医科大学, 医学部, 助教 (50322904)
KATAYAMA Akihiro  旭川医科大学, 医学部, 助教 (40374805)
ISHII Hideyuki  旭川医科大学, 医学部, 助教 (90360982)
YOSHIZAKI Tomoki  旭川医科大学, 医学部, 助教 (60422052)
UEDA Seigo  旭川医科大学, 医学部, 助教 (90447102)
岸部 幹  旭川医科大学, 医学部, 助教 (80447101)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords病巣感染 / 扁桃病巣疾患 / 掌蹠膿疱症 / 扁桃病巣感染症 / IgA腎症 / 掌蹠膿庖症 / 咽頭・扁桃炎
Research Abstract

Pustulosis palmaris et plantaris (PPP) is a tonsilrelated disease that can be cured with tonsillectomy. CCR6 and ss1 integrin expression on T cells in tonsils and that CCR6 and ss1 integrin positive T cells may move to peripheral blood circulation, resulting in recruitment to target skin lesions in PPP patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (4 results) Book (3 results) Remarks (4 results)

  • [Journal Article] Up-regulation of s1 integrin on tonsillar T cells and its induction byin vitro stimulation with α-streptococci in patients with pustulosis Palmaris et Plantaris2010

    • Author(s)
      Seigo Ueda, Miki Takahara, Toshitaka Tohtani, Tomoki Yoshizaki, Kan Kishibe, Yasuaki Harabuchi
    • Journal Title

      J Clin Immunol 30

      Pages: 861-871

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【耳鼻咽喉科外来診療 私の工夫】扁桃処置と上咽頭処置2010

    • Author(s)
      原渕保明、岸部幹
    • Journal Title

      ENTONI 113

      Pages: 91-98

    • NAID

      120005315220

    • Related Report
      2010 Final Research Report
  • [Journal Article] 掌蹠膿疱症における扁桃摘出術についてのアンケート調査 耳鼻咽喉科医および皮膚科医からみた考え方2010

    • Author(s)
      吉崎智貴
    • Journal Title

      耳鼻咽喉科臨床 103

      Pages: 27-33

    • NAID

      10026216298

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation ol Bl integrin on tonsillar T cells and its induction. by in vitro stimulation with α-streptococci in patients with pustulosis Palmaris et Plantaris.2010

    • Author(s)
      Ueda S, Takahara M, et al
    • Journal Title

      J Clin Immunol

      Volume: 30 Pages: 861-871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【耳鼻咽喉科外来診療 私の工夫】扁桃処置と上咽頭処置2010

    • Author(s)
      原渕保明、岸部幹
    • Journal Title

      ENTONI

      Volume: 113 Pages: 91-98

    • NAID

      120005315220

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris2009

    • Author(s)
      Tomoki Yoshizaki, Nobuyuki Bandoh, Seigo Ueda, Hayabusa Nozawa, Takashi Goto, Kan Kishibe, Miki Takahara, Yasuaki Harabuchi
    • Journal Title

      Clin Exp Immunol 157

      Pages: 71-82

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 扁桃シンポジウム 扁桃病巣皮膚疾患に対する扁桃摘出術の効果と限界 尋常性乾癬、アナフィラクトイド紫斑病、ベーチェット病等の扁桃病巣皮膚疾患における扁桃摘出術の有効性2009

    • Author(s)
      高原幹
    • Journal Title

      口腔・咽頭科 22

      Pages: 43-47

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of CC chemokine receptor 6 on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris.2009

    • Author(s)
      Yoshizaki T, Bandoh N, et al
    • Journal Title

      Clin Exp Immunol 157

      Pages: 71-82

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 扁桃病巣疾患における扁桃細菌叢の検討2008

    • Author(s)
      上田征吾,坂東伸幸,高原幹,吉崎智貴,原渕保明
    • Journal Title

      日本耳鼻感染症誌 26

      Pages: 149-152

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症における扁桃摘出術の適応をどう考えるか?2008

    • Author(s)
      吉崎智貴,高原幹,坂東伸幸,原渕保明
    • Journal Title

      JOHNS 24

      Pages: 1557-1561

    • Related Report
      2010 Final Research Report
  • [Journal Article] Increase in BAFF and IFN-gamma productions by tonsillar mononuclear cells stimulated with CpG-ODN in patients with IgA nephropathy2008

    • Author(s)
      Takashi Goto, Nobuyuki Bandoh, Tomoki Yoshizaki, Hayabusa Nozawa, Miki Takahara, Seigo Ueda, Tatsuya Hayashi, Yasuaki Harabuchi
    • Journal Title

      Clin Immunol 126

      Pages: 260-269

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increast in BAFF and IFN-gamma productions by tonsillar mononuciear cells stimulated wih CpG-ODN in patients with IgA nephropoathy2008

    • Author(s)
      Goto T, Bandoh N, et.al.
    • Journal Title

      Clin Immunol 126

      Pages: 260-269

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 扁桃病巣疾患における扁桃細菌叢の検討2008

    • Author(s)
      上田征吾, 坂東伸幸, 他
    • Journal Title

      日本耳鼻感染症誌 26

      Pages: 149-152

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症における扁桃摘出術の適応をどう考えるか?2008

    • Author(s)
      吉崎智貴, 坂東伸幸, 他2名
    • Journal Title

      JOHNS 24(10)

      Pages: 1557-1561

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of B1 integrin on tonsillar T-cells from the patients with pustulosis palmaris et plantaris (PPP)2009

    • Author(s)
      上田征吾
    • Organizer
      The 10th Japan-Taiwan Conference in Oto-Rhino-Laryngology, Head and Neck Surgery
    • Place of Presentation
      Yilan, Taiwan
    • Year and Date
      2009-10-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Expression of β1 integrin on tonsillar T-cells from the patients with pustulosis palmaris et plantaris(PPP)2009

    • Author(s)
      Ueda T
    • Organizer
      The 10^<th> Japan-Taiwan Conference in Oto-Rhino-Laryngology, Head and Neck Surgery
    • Place of Presentation
      Yilan, Taiwan
    • Year and Date
      2009-10-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 掌蹠膿疱症におけるCD29の発現2009

    • Author(s)
      上田征吾,高原幹,吉崎智貴,坂東伸幸,原渕保明
    • Organizer
      日本口腔・咽頭科学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2009-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 掌蹠膿疱症におけるCD29の発現2008

    • Author(s)
      上田征吾, 坂東伸幸, 他2名
    • Organizer
      日本口腔・咽頭科学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Book] 扁桃病巣感染症 口腔咽頭の臨床2009

    • Author(s)
      上田征吾
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Book] 咽頭・扁桃炎のマネジメント2009

    • Author(s)
      坂東伸幸,原渕保明,高原幹
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 咽頭・扁桃炎のマネジメント2009

    • Author(s)
      坂東伸幸, 原渕保明, 高原幹
    • Total Pages
      23
    • Publisher
      医薬ジャーナル社
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawar-ed.ac.jp/dept/mc/oto/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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