Analysis of pattern generating neural networks for laryngeal multifunctional activities.

• Project/Area Number: 20592010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Chiba University
• Principal Investigator: NAKAZAWA Ken Chiba University, 大学院・医学研究院, 講師 (10312943)
• Co-Investigator(Kenkyū-buntansha): SHIMOYAMA Ichiro 千葉大学, フロンティアメディカル工学研究開発センター, 教授 (60115483)
• Co-Investigator(Renkei-kenkyūsha): UMEZAKI Toshiro 九州大学, 医学部附属病院, 講師 (80223600)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 喉頭科学 / 脳・神経

Research Abstract

The larynx serves various behaviors including vocalization and upper airway reflexes such as swallowing. It is considered that the motor output during these behaviors is controlled by pattern generating neural networks in the brainstem. In this study, the brainstem vocal sites were identified in the region between the midbrain and the medulla in guinea pigs. Swallowing-related neurons (SRNs) were identified, which has demonstrated that the SRNs exhibit various types of firing patterns during swallowing and that the SRNs form the neural network for swallowing with their complex axonal projections within the medulla.

Research Products

• [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs. (2011)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Umezaki T, Ezure K, Abo N, Yoshihara T, Hisa Y.
  • Journal Title: The Journal of Comparative Neurology in press.
  • Peer Reviewed
• [Journal Article] Axonal projections of medullary swallowing neurons in guinea pigs. (2011)
  • Author(s): Sugiyama Y, et.al
  • Journal Title: The Journal of Comparative Neurology Volume: In press
  • Peer Reviewed
• [Journal Article] Swallow-related inhibition in laryngeal motoneurons. (2010)
  • Author(s): Suzuki T, Shiba K, Nakazawa K.
  • Journal Title: Neuroscience Research 67 Pages: 327-333
  • Peer Reviewed
• [Journal Article] Brainstem vocalization area in guinea pigs. (2010)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T, Hisa Y.
  • Journal Title: Neuroscience Research 66 Pages: 359-365
  • Peer Reviewed
• [Journal Article] Brainstem vocalization area in guinea pigs. (2010)
  • Author(s): Sugiyama Y, et.al
  • Journal Title: Neuroscience Research Volume: 66 Pages: 359-365
  • Peer Reviewed
• [Presentation] Brainstem vocalization regions in guinea pigs. (2010)
  • Author(s): Sugiyama Y, Suzuki T, Shiba K, Nakazawa K, Hisa Y.
  • Organizer: 7^<th> FENS FORUM OF NEUROSCIENCE
  • Place of Presentation: Amsterdam, The Netherlands.
  • Year and Date: 2010-07-06
• [Presentation] Brainstem vocalization regions in guinea pigs (2010)
  • Author(s): Sugiyama Y, et.al
  • Organizer: 7^<th> FENS FORUM OF NEUROSCIENCE
  • Place of Presentation: オランダアムステルダム
  • Year and Date: 2010-07-06
• [Presentation] Brainstem vocal sites in guinea pigs. (2009)
  • Author(s): Sugiyama Y, Shiba K, Nakazawa K, Suzuki T.
  • Organizer: THE 39^<th> ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE
  • Place of Presentation: Chicago, USA.
  • Year and Date: 2009-10-21
• [Presentation] Brainstem vocal sites in guinea pigs (2009)
  • Author(s): Y.Sugiyama
  • Organizer: 米国神経科学学会
  • Place of Presentation: 米国 シカゴ
  • Year and Date: 2009-10-21
• [Presentation] Swallowing-related inhibitory inputs to laryngeal motoneurons. (2008)
  • Author(s): Suzuki T, Nakazawa K, Shiba K, Ono K.
  • Organizer: THE 38^<th> ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE
  • Place of Presentation: Washington DC, USA.
  • Year and Date: 2008-11-18
• [Presentation] Swallowing-related inhibitory inputs to laryngeal motoneurons (2008)
  • Author(s): 中澤健
  • Organizer: 米国神経科学学会
  • Place of Presentation: 米国ワシントンD. C.
  • Year and Date: 2008-11-18