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Role of Neuropeptide Signals Induced Metastasis of Hypopharyngeal Cancer

Research Project

Project/Area Number 20592011
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionChiba University

Principal Investigator

HANAZAWA Toyoyuki  Chiba University, 大学院・医学研究院, 准教授 (90272327)

Co-Investigator(Kenkyū-buntansha) 関 直彦  千葉大学, 大学院・医学研究院, 准教授 (50345013)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords下咽頭癌 / ゲノム / 神経ペプチド / マイクロRNA / 遺伝子解析 / 癌 / マイクロアレイ / ニューロテンシン
Research Abstract

Distant metastasis is a major factor associated with poor prognosis in hypopharyngeal squamous cell carcinomas (HSCC), but little is known of its molecular mechanisms. New markers that predict clinical outcome, in particular the ability of primary tumors to develop metastatic tumors, are urgently needed. We narrowed our focus to the analysis of the neurotensin (NT) and neurotensin receptor (NTR) oncogenic signal pathways. In HSCC cells, which expressed NTR, a NT agonist promoted cellular invasion, migration and induction of several mRNAs, such as interleukin 8 and matrix metalloproteinase 1 transcripts. Our findings suggest a critical role for the NT and NTR oncogenic pathways in invasion and migration of HSCC cells during the metastatic process. Our study raises the possibility that NT and NTR could be a useful predictive marker of poor prognosis in patients with HSCC.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2011 2010 2009 2008

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma.2011

    • Author(s)
      Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Fujimura L, Yoshino H, Kawakami K, Chiyomaru T, Enokida H, Nakagawa M, Okamoto Y, Seki N
    • Journal Title

      Int J Oncol. 38(1)

      Pages: 209-217

    • Related Report
      2010 Final Research Report
  • [Journal Article] Caveolin-1 mediates tumor cell migration and invasion and its regulation by miR-133a in head and neck squamous cell carcinoma.2011

    • Author(s)
      野畑二次郎
    • Journal Title

      Int J Oncol

      Volume: 38 Pages: 209-217

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma.2011

    • Author(s)
      野畑二次郎
    • Journal Title

      oncotarget.

      Volume: 2 Pages: 29-44

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-489 is a tumour-suppressive miRNA target PTPN11 in hypopharyngeal squamous cell carcinoma (HSCC).2010

    • Author(s)
      Kikkawa N, Hanazawa T, Fujimura L, Nohata N, Suzuki H, Chazono H, Sakurai D, Horiguchi S, Okamoto Y, Seki N.
    • Journal Title

      Br J Cancer. 7;103(6)

      Pages: 877-884

    • Related Report
      2010 Final Research Report
  • [Journal Article] マイクロRNA(miR-145、miR-133a・b)の頭頸部扁平上皮癌における増殖・浸潤抑制機能と標的遺伝子の同定2010

    • Author(s)
      花澤豊行, 吉川直子, 野畑二次郎, 堅田浩司, ムラディル・ムラリフ, 鈴木誉, 佐々木慶太, 茶薗英明, 堀口茂俊, 岡本美孝, 関直彦
    • Journal Title

      頭頸部癌 36(1)

      Pages: 1-8

    • NAID

      10029079202

    • Related Report
      2010 Final Research Report
  • [Journal Article] miR-489 is a tumour-suppressive miRNA target PTPNIl in hypop haryngeal squamous cell carcinoma(HSCC).2010

    • Author(s)
      吉川直子
    • Journal Title

      Br J Cancer.

      Volume: 103 Pages: 77-84

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] マイクロRNA(miR-l45、miR-133a・b)の頭頸部扁平上皮癌における増殖・浸潤抑制機能と標的遺伝子の同定2010

    • Author(s)
      花澤豊行
    • Journal Title

      頭頸部癌

      Volume: 36 Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.2009

    • Author(s)
      Sugimoto T, Seki N, Shimizu S, Kikkawa N, Tsukada J, Shimada H, Sasaki K, Hanazawa T, Okamoto Y, Hata A
    • Journal Title

      Genes Chromosomes Cancer. 48(2)

      Pages: 132-142

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of a novel therapeutic target for head and neck squamous cell carcinomas : A role for the neurotensin-neurotensin receptor 1 oncogenic signaling pathway.2008

    • Author(s)
      Shimizu S, Tsukada J, Sugimoto T, Kikkawa N, Sasaki K, Chazono H, Hanazawa T, Okamoto Y, Seki N
    • Journal Title

      Int J Cancer. 15;123(8)

      Pages: 1816-1823

    • Related Report
      2010 Final Research Report
  • [Journal Article] Identification of a novel therapeutic target for head and neck squamous cell carcinomas: A role for the neurotensin-neurotensin receptor 1 oncogenic signaling pathway.2008

    • Author(s)
      清水惠也
    • Journal Title

      Int J Cancer 123

      Pages: 1816-1823

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The galanin signaling cascade is a candidate pathway regulating oncogenesis in human squamous cell carcinoma.2008

    • Author(s)
      杉本貴司
    • Journal Title

      Gene Chromosome Cancer 48

      Pages: 132-142

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] miR-133aas a tumor suppressive microRNA targeting multiple oncogenes in head neck squamous cell carcinoma.2011

    • Author(s)
      Nohata N.
    • Organizer
      AACR102nd
    • Place of Presentation
      Orland
    • Year and Date
      2011-04-03
    • Related Report
      2010 Final Research Report
  • [Presentation] miR-133a as a tumor suppressive microRNA targeting multiple oncogenes in head neck squamous cell carcinoma.2011

    • Author(s)
      野畑二次郎
    • Organizer
      第102回アメリカ癌学会
    • Place of Presentation
      オーランド
    • Year and Date
      2011-04-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下咽頭癌miRNA発現プロファイルに基づく癌抑制miRNAの探索2010

    • Author(s)
      吉川直子
    • Organizer
      日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] miR-15a as potential therapeutic molecule for head and neck squamous cell carcinoma (HNSCC).2010

    • Author(s)
      花澤豊行
    • Organizer
      AACR101st
    • Place of Presentation
      Washington DC
    • Year and Date
      2010-04-19
    • Related Report
      2010 Final Research Report
  • [Presentation] miR-15a as potential therapeutic molecule for head and neck squamous cell carcinoma(HNSCC).2010

    • Author(s)
      花澤豊行
    • Organizer
      第101回アメリカ癌学会
    • Place of Presentation
      ワシントンDC
    • Year and Date
      2010-04-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 下咽頭SCCの遺伝子発現プロファイルによるmicroRNA発現多様性の同定2009

    • Author(s)
      吉川直子
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 血液中に存在するマイクロRNAを指標とした頭頸部扁平上皮癌診断マーカーの探索2009

    • Author(s)
      花澤豊行
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ニューロテンシンシグナルによる頭頸部扁平上皮癌転移・浸潤機構の解明2008

    • Author(s)
      花澤豊行
    • Organizer
      第68回日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Neurotensin signaling pathway is a novel therapeutic target for head and neck squamous cell carcinomas2008

    • Author(s)
      花澤豊行
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2008-10-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] ゲノム解析に基づく頭頸部扁平上皮癌・分子標的の探索(1)ガラニンレセプターを介するシグナル伝達機構の解明2008

    • Author(s)
      花澤豊行
    • Organizer
      第32回日本頭頸部癌学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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