histological investigation of thermosensitivity in the laryngopharynx.

Research Project

Project/Area Number	20592017
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Otorhinolaryngology
Research Institution	Tottori University
Principal Investigator	MIYAKE Naritomo Tottori University, 医学部・附属属病院, 医員 (60464278)
Co-Investigator(Kenkyū-buntansha)	KAWAMOTO Katsuyuki 鳥取大学, 医学部, 助教 (50304217) KITANO Hiroya 鳥取大学, 医学部, 教授 (20153108)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	温度受容 / 免疫染色 / VR1 / TRPM8 / TRPM5 / VRI / 咽喉頭領域 / 温度受容体 / 咽喉頭 / 神経節
Research Abstract	It is not investigated in detail about thermosensitivity of laryngopharynx. We guess transiend receptor potential (TRP) family receptors have an intimate involvement in thermosensitivity of laryngopharynx. Most famous receptor is vanilloid receptor type 1(VR1) that is known as capsaicin receptor. We use immunostaining method with VR1, PV5 and PM8 in dorsal root ganglion and trigeminal nerve of Rat. We found VR1 and TRPM positive neuron cell in dorsal root ganglion and trigeminal nerve.