Development of new cancer treatment using anticancer effect of D-allose

• Project/Area Number: 20592019
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kagawa University
• Principal Investigator: HOSHIKAWA Hiroshi Kagawa University, 医学部, 准教授 (70294767)
• Co-Investigator(Kenkyū-buntansha): 三谷 知生 香川大学, 医学部附属病院, 助教 (40380183)
• Research Collaborator: MORI Terushige NTT西日本大阪病院, 耳鼻咽喉科 ; INDO Kanako 香川大学, 医学部・耳鼻咽喉科, 助教 (90380188)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: D-allose / anticancer effect / head and neck / allose / growth inhibition / radiation enhancement / reactive oxygen species / in vivo / radiation / anticancer drug / TXNIP

Research Abstract

D-allose exerts growth inhibitory effects on head and neck cancer cells in vitro and in vivo. The combination of D-allose and radiation significantly induced intracellular reactive oxygen species (ROS) and apoptosis compared to that induced by either agent alone. The sugar may act as an anti-proliferative agent via TXNIP induction and thus be useful as a novel anticancer drug.

Research Products

• [Journal Article] Enhancement of the radiation effects by d-allose in head and neck cancer cells. (2011)
  • Author(s): Hoshikawa H, Indo K, Mori T, Mori N.
  • Journal Title: Cancer Lett. [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] Enhancement of the radiation effects by D-allose in head and neck cancer cells (2011)
  • Author(s): Hoshikawa H
  • Journal Title: Cancer Letters Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] In vitro and in vivo effects of D-allose : up-regulation of thioredoxin-interacting protein in head and neck cancer cells. (2010)
  • Author(s): Hoshikawa H, Mori T, Mori N.
  • Journal Title: Ann Otol Rhinol Laryngol. 119(8) Pages: 567-571
  • Peer Reviewed
• [Journal Article] In vitro and in vivo effects of D-allose-up-regulation of TXNIP in head and neck cancer cells (2010)
  • Author(s): Hoshikawa H
  • Journal Title: Annals of Otology, Rhinology & Laryngology (In press)
  • Peer Reviewed
• [Journal Article] Growth inhibition of head and neck carcinomas by D-allose. (2009)
  • Author(s): Mitani T, Hoshikawa H, Mori T, Hosokawa T, Tsukamoto I, Yamaguchi F, Kamitori K, Tokuda M, Mori N.
  • Journal Title: Head Neck. 31(8) Pages: 1049-1055
  • Peer Reviewed
• [Journal Article] Growth inhibition of head and neck carcinomas by D-Allose (2009)
  • Author(s): Mitani T, Hoshikawa H, Mori T et. al
  • Journal Title: Head and Neck (未定)(掲載確定)
  • Peer Reviewed
• [Presentation] 頭頸部扁平上皮癌細胞株に対する D-allose の効果～docetaxel との併用効果～ (2009)
  • Author(s): 森照茂
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: (ロイトン札幌)北海道
  • Year and Date: 2009-06-11
• [Presentation] 頭頸部扁平上皮癌細胞株に対するD-alloseの効果～docetaxelとの併用効果～ (2009)
  • Author(s): 森照茂、星川広史、森望
  • Organizer: 第33回日本頭頸部癌学会
  • Place of Presentation: ロイトン札幌
• [Presentation] Inhibitory effect of D-allose on cancer growth in vitro and in vivo (2008)
  • Author(s): 星川広史
  • Organizer: International Society of Rare Sugar Congress 2008
  • Place of Presentation: かがわ国際会議場