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Development of new cancer treatment using anticancer effect of D-allose

Research Project

Project/Area Number 20592019
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKagawa University

Principal Investigator

HOSHIKAWA Hiroshi  Kagawa University, 医学部, 准教授 (70294767)

Co-Investigator(Kenkyū-buntansha) 三谷 知生  香川大学, 医学部附属病院, 助教 (40380183)
Research Collaborator MORI Terushige  NTT西日本大阪病院, 耳鼻咽喉科
INDO Kanako  香川大学, 医学部・耳鼻咽喉科, 助教 (90380188)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsD-allose / anticancer effect / head and neck / allose / growth inhibition / radiation enhancement / reactive oxygen species / in vivo / radiation / anticancer drug / TXNIP
Research Abstract

D-allose exerts growth inhibitory effects on head and neck cancer cells in vitro and in vivo. The combination of D-allose and radiation significantly induced intracellular reactive oxygen species (ROS) and apoptosis compared to that induced by either agent alone. The sugar may act as an anti-proliferative agent via TXNIP induction and thus be useful as a novel anticancer drug.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (3 results)

  • [Journal Article] Enhancement of the radiation effects by d-allose in head and neck cancer cells.2011

    • Author(s)
      Hoshikawa H, Indo K, Mori T, Mori N.
    • Journal Title

      Cancer Lett. [Epub ahead of print]

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the radiation effects by D-allose in head and neck cancer cells2011

    • Author(s)
      Hoshikawa H
    • Journal Title

      Cancer Letters

      Volume: (掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo effects of D-allose : up-regulation of thioredoxin-interacting protein in head and neck cancer cells.2010

    • Author(s)
      Hoshikawa H, Mori T, Mori N.
    • Journal Title

      Ann Otol Rhinol Laryngol. 119(8)

      Pages: 567-571

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo effects of D-allose-up-regulation of TXNIP in head and neck cancer cells2010

    • Author(s)
      Hoshikawa H
    • Journal Title

      Annals of Otology, Rhinology & Laryngology (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition of head and neck carcinomas by D-allose.2009

    • Author(s)
      Mitani T, Hoshikawa H, Mori T, Hosokawa T, Tsukamoto I, Yamaguchi F, Kamitori K, Tokuda M, Mori N.
    • Journal Title

      Head Neck. 31(8)

      Pages: 1049-1055

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Growth inhibition of head and neck carcinomas by D-Allose2009

    • Author(s)
      Mitani T, Hoshikawa H, Mori T et. al
    • Journal Title

      Head and Neck (未定)(掲載確定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭頸部扁平上皮癌細胞株に対する D-allose の効果~docetaxel との併用効果~2009

    • Author(s)
      森照茂
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      (ロイトン札幌)北海道
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭頸部扁平上皮癌細胞株に対するD-alloseの効果~docetaxelとの併用効果~2009

    • Author(s)
      森照茂、星川広史、森望
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      ロイトン札幌
    • Related Report
      2010 Final Research Report
  • [Presentation] Inhibitory effect of D-allose on cancer growth in vitro and in vivo2008

    • Author(s)
      星川広史
    • Organizer
      International Society of Rare Sugar Congress 2008
    • Place of Presentation
      かがわ国際会議場
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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