Roles of stromal cells in the survival, growth, differentiation, migration of laryngeal carcinoma-derived cancer stem cells and its mechanisms
| Project/Area Number |
20592023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Saga University |
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Principal Investigator |
TODA Shuji Saga University, 医学部, 教授 (80188755)
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| Co-Investigator(Kenkyū-buntansha) |
KURATOMI Yuichiro 佐賀大学, 医学部, 准教授 (30225247)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 喉頭癌 / 癌幹細胞 / 線維芽細胞 / 脂肪細胞 / 増殖 / アポトーシス / 遊走 / 浸潤 |
|---|
| Research Abstract |
Stromal fibroblasts promote the survival, self-renewal and cancer cell production of cancer stem cells under cancer stem cell-fibroblast interaction, while both adipocytes and adipose tissues tend to inhibit those of the cancer stem cells. Adipose tissue-derived free fatty acid, palmitate, tends to promote the apoptosis of cancer stem cells. Finally, the stromal-cancer stem cell interaction does not induce the significant changes ofadipokine production and gene expression.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] The air liquid-interface, a skin microenvironment, promotes growth of melanoma cells, but not their apoptosis and invasion, through activation of mitogen-activated protein kinase.2010
Author(s)
Yee CH, Aoki S, Uchihashi K, Matsunobu A, Yamasaki F, Misago N, Piao M, Tetsuji U, Yonemitsu N, Sugihara H, Toda S.
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Journal Title
Acta Histochem Cytochem 43
Pages: 1-7
NAID
Related Report
Peer Reviewed
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[Journal Article] A new organotypic culture of adipose tissue fragments maintains viable mature adipocytes for a long term, together with development of immature adipocytes and mesenchymal stem cell-like cells.2008
Author(s)
Sonoda E, Aoki S, Uchihashi K, Soejima H, Kanaji S, Izuhara K, Satoh S, Fujitani N, Sugihara H, Toda S.
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Journal Title
Endocrinology 149
Pages: 4794-4798
Related Report
Peer Reviewed
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