• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Effect of mTOR inhibitors on radiation sensitivity of head and neck cancer cells

Research Project

Project/Area Number 20592025
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNara Medical University

Principal Investigator

OTA Ichiro  Nara Medical University, 医学部, 助教 (00326323)

Co-Investigator(Kenkyū-buntansha) YANE Katsunari  近畿大学, 医学部, 教授 (40220199)
AKAHASHI Akihisa  群馬大学, 先端科学研究指導者育成ユニット, 准教授 (60275336)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords頭頸部がん / 放射線治療 / 抗がん剤 / mTOR / p53 / アポトーシス / 放射線
Research Abstract

A high extent of activation of the PI3K/Akt pathway is involved in head and neck cancer therapeutic resistance, including radiotherapy and chemotherapy. The aim of this study was to examine whether the effect of rapamycin, an inhibitor of mTOR, on chemo- and radio-sensitivity is affected in human head and neck cancer cells. Rapamycin could enhance the effect of radiation and cisplatin through the repression of pro-survival signals, including PI3K/Akt pathway, and the reduction in the apoptotic threshold.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 14 results) Presentation (24 results) Remarks (1 results)

  • [Journal Article] Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.2010

    • Author(s)
      Nagata Y, Takahashi A, Ohnishi K, Ota I, Ohnishi T, Tojo T, Taniguchi S
    • Journal Title

      Int J Oncol. 37(4)

      Pages: 1001-1010

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Snail1 is stabilized by O-GlcNAc modification in hyperglycemic condition.2010

    • Author(s)
      Park SY, Kim HS, Kim NH, Ji S, Cha SY, Kang JG, Ota I, Shimada K, Konishi N, Nam HW, Hong SW, Yang WH, Roth J, Yook JI, Cho JW
    • Journal Title

      EMBO J. 29(22)

      Pages: 3787-3796

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] SnailによるMT1-MMPおよびMT2-MMPの癌浸潤・転移の制御2010

    • Author(s)
      太田一郎、家根旦有、細井裕司
    • Journal Title

      耳鼻免疫アレルギー 28(3)

      Pages: 235-238

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 明日の診療に役立つ頭頸部癌の基礎研究-分子標的治療、癌幹細胞と浸潤・転移2010

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司
    • Journal Title

      頭頸部癌 36(4)

      Pages: 442-446

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.2010

    • Author(s)
      Nagata Y, Takahashi A, Ohnishi K, Ota I, Ohnishi T, Tojo T, Taniguchi S
    • Journal Title

      International Journal of Oncology

      Volume: 37 Pages: 1001-1010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 明日の診療に役立つ頭頸部癌の基礎研究分子標的治療:癌幹細胞と浸潤転移2010

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司
    • Journal Title

      頭頸部癌36(4):442-446

      Volume: 36 Pages: 442-446

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Snaill is stabilized by O-GlcNAc modification in hyperglycemic condition2010

    • Author(s)
      Park SY ; Ota I, Yook JI, et al
    • Journal Title

      EMBO J

      Volume: 29 Pages: 3787-3796

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1.2009

    • Author(s)
      Ota I, Li XY, Hu Y, Weiss SJ
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 20318-20323

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snaill2009

    • Author(s)
      Ichiro Ota, Xiao Yan Li, Yuexian Hu, Stephen J.Weiss
    • Journal Title

      Proc.Natl.Acad.Sci.USA 106

      Pages: 20318-20323

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Snail を介したWntシグナル伝達によるがんの浸潤・転移の制御2009

    • Author(s)
      太田一郎, 家根旦有, 細井裕司
    • Journal Title

      耳鼻咽喉科免疫アレルギー 27

      Pages: 107-108

    • NAID

      10030883298

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer.2008

    • Author(s)
      Konishi N, Shimada K, Nakamura M, Ishida E, Ota I, Tanaka N, Fujimoto K
    • Journal Title

      Clin Cancer Res. 14(14)

      Pages: 4408-4416

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase.2008

    • Author(s)
      Li XY, Ota I, Yana I, Sabeh F, Weiss SJ
    • Journal Title

      Mol Biol Cell. 19(8)

      Pages: 3221-3233

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Dissection of the Structural Machinery Underlying the Tissue-Invasive Activity of MTl-MMP.2008

    • Author(s)
      XiaoYan Li, Ichiro Ota, Farideh Sabeh. Stephen J. Weiss
    • Journal Title

      Molecular Biology of the Cell 19(8)

      Pages: 3221-3233

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Function of JunB in transient amplifying cell senescence and progression of human prostate cancer.2008

    • Author(s)
      Noboru Konishi, Keiji Shimada, Mitsutoshi Nakamura, Eiwa Ishida, Ichiro Ota, Nobumichi Tanaka, Kiyohide Fujimoto
    • Journal Title

      Clinical Cancer Research 14

      Pages: 4408-4416

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] WntシグナルによるSnailの活性化を介しか癌の浸潤・転移の獲得2008

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司
    • Journal Title

      頭頭部癌 34

      Pages: 19-23

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Snail1 mobilizes the membrane- anchored collagenases, MT1-MMP and MT2-MMP, to drive cancer invasion programs.2010

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司
    • Organizer
      The 8^<th> AHNS 2010 Research Workshop on the Biology, Prevention and Treatment of Head and Neck Cancer.
    • Place of Presentation
      Arlington, VA, USA
    • Year and Date
      2010-10-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells.2010

    • Author(s)
      太田一郎, 高橋昭久, 家根旦有, 岡本倫朋, 細井裕司, 大西武雄
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-09-24
    • Related Report
      2010 Final Research Report
  • [Presentation] Snail mobilizes the membrane-anchored collagenases, MT1-MMP and MT2-MMP, to drive cancer cell invasion programs.2010

    • Author(s)
      太田一郎, 家根旦有, 岡本倫朋, 細井裕司
    • Organizer
      The 13^<th> Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery.
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 明日の診療に役立つ頭頸部癌の基礎研究I.分子標的治療:癌幹細胞と浸潤・転移2010

    • Author(s)
      太田一郎
    • Organizer
      第34回日本頭頸部癌学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] がん癌研究up to date 2010世界の基礎研究の動向2010

    • Author(s)
      太田一郎
    • Organizer
      第4回頭頸部基礎研究会
    • Place of Presentation
      東京都
    • Year and Date
      2010-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] SnailによるMT1-MMPおよびMT2-MMP依存性の癌浸潤能の誘導2010

    • Author(s)
      太田一郎、家根旦有、細井裕司
    • Organizer
      第111回日本耳鼻咽喉科総会学術集会
    • Place of Presentation
      仙台市
    • Year and Date
      2010-05-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Snail1によるMT-MMPおよびMT2-MMPの癌浸潤・転移能の制御2010

    • Author(s)
      太田一郎、細井裕司
    • Organizer
      第28回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      福井市
    • Year and Date
      2010-02-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Snailを介したWntシグナル伝達によるがんの浸潤・転移の制御2010

    • Author(s)
      太田一郎、岡本倫朋、澤西和恵、家根旦有、細井裕司
    • Organizer
      第12回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良市
    • Year and Date
      2010-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells2010

    • Author(s)
      Ota I, Takahashi A, Yane K, Okamoto N, Hosoi H, Ohnishi T
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪市
    • Related Report
      2010 Annual Research Report
  • [Presentation] The membrane-anchored collagenase MT1-MMP and MT2-MMP mediate tumor cell traffic through the extracellular matrix cooperatively in vivo2010

    • Author(s)
      Ichiro Ota, Farideh Sabeh, Xiao-Yan Li, Katsunari Yane, Hiroshi Hosoi, Stephen J Weiss
    • Organizer
      100^<th> Annual Meeting 2009 of AACR
    • Place of Presentation
      Denver, Colorado, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells2010

    • Author(s)
      太田一郎, 家根旦有, 高橋昭久, et al
    • Organizer
      2nd Asian Congress of Radiation Research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2009 Annual Research Report
  • [Presentation] Snail を介したWntシグナル伝達によるがんの浸潤・転移の制御2010

    • Author(s)
      太田一郎, 家根旦有, 細井裕司
    • Organizer
      第27回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      三井ガーデンホテル・千葉市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭頸部がん細胞におけるmTORシグナル経路を標的としたシスプラチン増感効果の検討2010

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司, 高橋昭久, 大西武雄
    • Organizer
      第11回癌治療増感研究シンポジウム
    • Place of Presentation
      猿沢荘、奈良市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Snail1 induces the membrane-anchored collagenases, MT1-MMP and MT2-MMP, to drive cancer cell invasion programs in vivo.2009

    • Author(s)
      Ota I, Yane K, Matsuura N, Takahashi A, Ohnishi T, Hosoi H
    • Organizer
      第68回日本癌学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] mTORシグナル経路を標的とした放射線増感効果の検討2009

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      札幌市
    • Year and Date
      2009-06-11
    • Related Report
      2010 Final Research Report
  • [Presentation] mTORシグナル経路を標的とした放射線増感効果の検討2009

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司
    • Organizer
      第33回日本頭頸部癌学会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頭頸部癌細胞におけるmTOR阻害薬による放射線増感効果の検討2009

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司
    • Organizer
      第309回日耳鼻大阪地方連合会
    • Place of Presentation
      大阪市
    • Year and Date
      2009-06-06
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭頸部癌細胞におけるmTOR阻害薬による放射線増感効果の検討2009

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司
    • Organizer
      第309回日耳鼻大阪地方連合会
    • Place of Presentation
      大阪大学中之島センター、大阪市
    • Year and Date
      2009-06-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rapamycin inhibits proliferation and enhances cisplatin-induced apoptosis in human head and neck cancer cells.2009

    • Author(s)
      Ota I, Yane K, Okamoto N, Takahashi A, Ohnishi K, Hosoi H, Ohnishi T
    • Organizer
      2nd Asian Congress of Radiation Research (ACRR)
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-17
    • Related Report
      2010 Final Research Report
  • [Presentation] The membrane-anchored collagenase MT1-MMP and MT2-MMP mediate tumor cell traffic through the extracellular matrix cooperatively in vivo2009

    • Author(s)
      Ota I, Sabeh F, Li XY, Yane K, Hosoi H, Weiss SJ
    • Organizer
      100th Annual Meeting of AACR
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      2009-04-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭頸部がん細胞におけるmTORシグナル経路を標的としたシスプラチン増感効果の検討2009

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司、大西健、高橋昭久、大西武雄
    • Organizer
      第11回癌治療増感研究シンポジウム
    • Place of Presentation
      奈良市
    • Year and Date
      2009-02-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Snailを介したWntシグナル伝達によるがんの浸潤・転移の制御2009

    • Author(s)
      太田一郎、家根旦有、細井裕司
    • Organizer
      第27回日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      千葉市
    • Year and Date
      2009-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] mTORシグナル経路を標的としたシスプラチン増感効果の検討2008

    • Author(s)
      太田一郎、岡本倫朋、家根旦有、細井裕司
    • Organizer
      第32回日本頭頸部癌学会
    • Place of Presentation
      東京都
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] mTORシグナル経路を標的としたシスプラチン増感効果の検討2008

    • Author(s)
      太田一郎, 岡本倫朋, 家根旦有, 細井裕司
    • Organizer
      第32回日本頭順部癌学会
    • Place of Presentation
      ハイアット リージェンシー 東京
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.naramed-u.ac.jp/~oto/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi