• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Amplification of Rad9 in head and neck cancer

Research Project

Project/Area Number 20592026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionJichi Medical University

Principal Investigator

ISHIKAWA Kazuhiro  Jichi Medical University, 医学部, 講師 (40296083)

Co-Investigator(Kenkyū-buntansha) ICHIMURA Keiichi  自治医科大学, 医学部, 教授 (00010471)
NISHINO Hiroshi  自治医科大学, 医学部, 准教授 (50245057)
ISHII Hideshi  九州大学, 生体防御医学研究所, 学術研究員 (10280736)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌幹細胞 / 癌治療
Research Abstract

In the recent years, evidence is increasing indicating the existence of a subpopulation of resistant tumor cells in head and neck squamous cell carcinoma that cannot be eradicated by chemotherapy or radiotherapy. Human Rad9 is involved in cell cycle checkpoints, repair of damaged DNA, and apoptosis. Previous studies suggest that Rad9 is frequently amplified in epithelial tumor cells of head and neck cancer, but little is known about its role in the development of head and neck cancer. Here we studied the direct association of Rad9 and p53 results in regulation of the expression of P21 gene. Immunohistochemistrical analysis in head and neck cancer detected the accumulation of Rad9 in the nuclei of tumor cells, which colocalized with p53. In addition, molecular biological studies revealed the direct association of Rad9 and Rev7, an error-prone DNA polymerase. Collectively, these findings suggest that hRad9 may play a role in genetic instability and carcinogenesis. Further experiments might reveal its role as a diagnostic and prognostic factor, and possibly as a therapeutic target.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (6 results)

All 2008

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] 頭頸部癌におけるRad9発現2008

    • Author(s)
      石川和宏、西野宏、市村恵一、石井秀始
    • Journal Title

      頭頸部癌 34巻

      Pages: 493-497

    • NAID

      10024931687

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頭頸部癌におけるRad9発現2008

    • Author(s)
      石川 和宏
    • Journal Title

      頭頚部癌 34

      Pages: 493-497

    • NAID

      10024931687

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭頸部癌におけるRad9の発現の検討2008

    • Author(s)
      石川和宏、西野宏、市村恵一、石井秀始
    • Organizer
      第32回頭頸部癌学会
    • Place of Presentation
      ハイアットリージェンシー東京 (東京)
    • Year and Date
      2008-06-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭頸部癌におけるRad9の発現の検討2008

    • Author(s)
      石川 和宏
    • Organizer
      第32回 頭頸部癌学会
    • Place of Presentation
      ハイアットリージェンシー東京(東京)
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] 頭頸部癌におけるRad9の発現の免疫組織学的検討2008

    • Author(s)
      石川和宏、西野宏、市村恵一、石井秀始
    • Organizer
      第109回日本耳鼻咽喉科学会総会
    • Place of Presentation
      リーガロイヤルホテル大阪(大阪)
    • Year and Date
      2008-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 頭頸部癌におけるRad9の発現の免疫組織学的検討2008

    • Author(s)
      石川 和宏
    • Organizer
      第109回 日本耳鼻咽喉科学会総会
    • Place of Presentation
      リーがロイヤルホテル大阪(大阪)
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi