Physiological evidence of supracricoid laryngectomy with CHEP

• Project/Area Number: 20592028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kitasato University
• Principal Investigator: NAKAYAMA Meijin 北里大学, 医学部, 講師 (20207955)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: Cricoarytenoid Unit / MDCT / 高速度撮影 / 喉頭機能温存 / 喉頭癌 / 喉頭亜全摘出術 / 喉頭機能 / 機能温存 / 音源定位 / 音声 / 生理的解析 / Laryngeal preservation / Neoglottis / Delphian node / Radiation failure / Laryngeal cancer / Laryngealpreservation / Margin study / Electromyography

Research Abstract

Three projects were conducted and the results reported.
1) Electromyography of cricoarytenoid unit : Mobility of the arytenoid was attributed to interaction between the interarytenoid muscle and posterior cricoarytenoid muscle. Reciprocal interaction between the interarytenoid muscle and posterior cricoarytenoid muscle alone is also capable of maintaining post-operative laryngeal functions after supracricoid laryngectomy with cricohyoidoepiglottopexy.
2) MDCT analysis of CAU : Anterior shifting of the unilateral arytenoid plays an important role in compensating for the inability to achieve neoglottic closure. These two results demonstrate that the unilateral arytenoid alone is capable of achieving sufficient neoglottic narrowing to compensate for the resected arytenoid. Three-dimensional analysis was useful to evaluate the physiological status of the neoglottis after supracricoid laryngectomy with cricohyoidoepiglottopexy.
3) High-speed digital imaging laryngoscopy of neoglottis : High-speed digital imaging analysis is effective in locating the sites responsible for voice production in patients who have undergone supracricoid laryngectomy with cricohyoidoepiglottopexy. This is the first study to clearly identify the neoglottal sound source in such patients, using a high-speed digital imaging system.

Research Products

• [Journal Article] Functional organ preservation for laryngeal cancer : Past, Present, and Future (2012)
  • Author(s): Nakayama, M., Laccourreye, O., Helsingr, C., Makito, O., Hayakawa, K
  • Journal Title: Jpn J Clin Oncol Volume: 42(3) Pages: 155-160
  • Peer Reviewed
• [Journal Article] Three-dimensional computed tomography analysis of neoglottis after supracricoid laryngectomy with CHEP (2012)
  • Author(s): Seino, Y., Nakayama, M., Okamoto, M., Hayashi, S
  • Journal Title: J Laryngol Otol
  • Peer Reviewed
• [Journal Article] Functional organ preservation for laryngeal cancer : Past, Present, and Future (2012)
  • Author(s): Meijin Nakayama
  • Journal Title: Jpn J Clin Oncol Volume: 42 Pages: 155-160
  • Peer Reviewed
• [Journal Article] Three-dimensional computed tomography analysis of neoglottis after supracricoid laryngectomy with CHEP (2012)
  • Author(s): Seino Yutomo
  • Journal Title: Journal of Laryngology and Otology Volume: 126 Pages: 385-390
  • Peer Reviewed
• [Journal Article] Clinical significance of intraoperative surgical margin study in supracricoid laryngectomy (2011)
  • Author(s): Nakayama, M., Okamoto, M., Iwabuchi, K., Mikami, T., Seino, Y
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 261-265
  • Peer Reviewed
• [Journal Article] Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation (2011)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Matsuki, T., Ogawa, A
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 268 Pages: 273-279
• [Journal Article] Clinical significance of intraoperative surgical margin study in supracricoid laryngectomy (2011)
  • Author(s): Nakayama, M., Okamoto, M., Iwabuchi, K., Mikami, T., Seino, Y.
  • Journal Title: Auris Nasus Larynx 38 Pages: 261-265
  • Peer Reviewed
• [Journal Article] Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation. (2011)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Matsuki, T., Ogawa, A.
  • Journal Title: Eur Arch Otorhinolaryngol 268 Pages: 273-279
  • Peer Reviewed
• [Journal Article] Clinical significance of intraoperative surgical margin study in supracricoid laryngectomy. (2011)
  • Author(s): Meijin Nakayama
  • Journal Title: Auris Nasus Larynx Volume: 38 Pages: 261-265
  • Peer Reviewed
• [Journal Article] Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation. (2011)
  • Author(s): Meijin Nakayama
  • Journal Title: Eur Arch Otorhinolaryngol Volume: 268 Pages: 273-279
  • Peer Reviewed
• [Journal Article] High speed digital imaging laryngoscopy of the neoglottis following supracricoid laryngectomy with cricohyoidoepiglottopexy (2010)
  • Author(s): Hayashi, S., Hirose, H., Tayama, N., Imagawa, H., Nakayama, M., Seino, Y., Okamoto, M., Kimura, M., Nito, T
  • Journal Title: J Laryngol Otol Volume: 124 Pages: 1234-1238
  • Peer Reviewed
• [Journal Article] Inverted epiglottis : A postoperative complication of supracricoid laryngectomy with cricohyoidoepiglottopexy (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Hayashi, S., Masaki, T., Yokobori, S., Takeda M
  • Journal Title: Auris Nasus Larynx Volume: 37 Pages: 609-614
  • Peer Reviewed
• [Journal Article] Inverted epiglottis : A postoperative complication of supracricoid laryngectomy with cricohyoidoepiglottopexy (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino, Y., Miyamoto, S., Hayashi, S., Masaki, T., Yokobori, S., Takeda M.
  • Journal Title: Auris Nasus Larynx 37 Pages: 609-614
  • Peer Reviewed
• [Journal Article] Inverted epiglottis : A postoperative complication of supracricoid laryngectomy with cricohyoidoepiglottopexy. (2010)
  • Author(s): Meijin Nakayama
  • Journal Title: Auris Nasus Larynx Volume: 37 Pages: 609-614
  • Peer Reviewed
• [Journal Article] 局所進行喉頭癌に対する喉頭亜全摘出術SCL-CHEPの切除限界 (2009)
  • Author(s): 中山明仁
  • Journal Title: 日気食会報 60 Pages: 86-89
  • NAID: 10026104542
  • Peer Reviewed
• [Journal Article] Clinical analyses of fifty supracricoid laryngectomized specimens : Evidence base supporting minimal margins (2009)
  • Author(s): MEIJIN NAKAYAMA
  • Journal Title: ORL 71 Pages: 305-311
  • Peer Reviewed
• [Journal Article] 喉頭亜全摘術Supracricoid laryngectomy : 切除断端の病理組織学的検討. (2008)
  • Author(s): 中山明仁
  • Journal Title: 喉頭 20 Pages: 68-71
  • NAID: 10024824202
  • Peer Reviewed
• [Journal Article] Supracricoid laryngectomy with cricohyoidoepiglottopexy or cricohyoido-pexy : Experience on 32 patients (2008)
  • Author(s): NAKAYAMA MEIJIN
  • Journal Title: Auris Nasus Larynx 35 Pages: 77-82
  • Peer Reviewed
• [Journal Article] Electromyography of the cricoarytenoid unit during supracricoid laryngectomy with a cricohyoidoepiglottopexy procedure (2007)
  • Author(s): Nakayama, M., Hirose, H., Miyamoto, S., Yokobori, S., Takeda, M., Seino, Y., Okamoto, M
  • Journal Title: J Laryngol Otol Volume: 121 Pages: 87-91
  • Peer Reviewed
• [Presentation] Role of supracricoid laryngectomy (2012)
  • Author(s): Meijin Nakayama
  • Organizer: Combined workshop for head and neck surgery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-03-17
• [Presentation] Autologous fat augmentation for insufficient neoglottal closure after SCL-CHEP : A preliminary report (2012)
  • Author(s): Nakayama, M., Watanabe, A., Tamura, e., Okamoto T., Y, Seino., Shunsuke M., Okamoto M
  • Organizer: 14th Japan-Korea ORL-HNS meeting
  • Place of Presentation: Kyoto Hotel Okura
• [Presentation] Supracricoid laryngectomy : Is there still a role for salvage SCPL-CHEP (2012)
  • Author(s): Nakayama, M
  • Organizer: Combined workshop for Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
• [Presentation] Clinical significance of positive Delphian node in supracricoid laryngectomy with Cricohyoidoepiglottopexy (2011)
  • Author(s): Meijin Nakayama
  • Organizer: 12TH Asia-Oceania Otolaryngology-HNS Congress
  • Place of Presentation: AUCKLAND, NEW ZEALAND
  • Year and Date: 2011-03-03
• [Presentation] Is there still a role for salvage SCPL-CHEP (2011)
  • Author(s): Nakayama, M., Seino Y., Okamoto M., Shunsuke M., Okamoto T
  • Organizer: AAO-HNS Annual meeting
  • Place of Presentation: San Francisco Convention Center, USA
• [Presentation] Salvage SCPL-CHEP (2011)
  • Author(s): Nakayama, M
  • Organizer: Annual meeting of Taiwan Head and Neck Cancer Association
  • Place of Presentation: Kaohsiung
• [Presentation] Clinical significance of positive Delphian node in supracricoid laryngectomy with cricohyoidoepiglottopexy (2011)
  • Author(s): Nakayama, M., Seino Y., Okamoto M., Shunsuke M., Okamoto T
  • Organizer: The 12th Asia-Oceania Otolaryngology Head and Neck Congress
  • Place of Presentation: Aotea Centre, Auckland, New Zealand
• [Presentation] Is there still a role for salvage SCPL-CHEP (2011)
  • Author(s): Meijin Nakayama
  • Organizer: American Academy of Otorhinolaryngology
  • Place of Presentation: San Francisco, USA
• [Presentation] Clinical significance of positive Delphian node in supracricoid laryngectomy with cricohyoidoepiglottopexy. (2011)
  • Author(s): Nakayama, M., Seino Y., Okamoto M., Shunsuke M., Okamoto T.
  • Organizer: The 12th Asia-Oceania Otolaryngology Head and Neck Congress
  • Place of Presentation: Aotea Centre, Auckland, New Zealand.
• [Presentation] 喉頭機能温存手術における喉頭亜全摘出術の役割 (2010)
  • Author(s): 中山明仁
  • Organizer: 日本気管食道科学会
  • Place of Presentation: ビーコンホール(大分県)
  • Year and Date: 2010-11-04
• [Presentation] Flaccid neoglottis following supracricoid laryngectomy : Laryngoscopic revision assisted by navigation system (2010)
  • Author(s): Meijin Nakayama
  • Organizer: 4TH World Voice Congress 2010
  • Place of Presentation: SEOUL (COEX), KOREA
  • Year and Date: 2010-09-08
• [Presentation] Delayed wound infection after supracricoid partial laryngectomy following failure of high dose radiation. (2010)
  • Author(s): Meijin Nakayama
  • Organizer: 4TH IFHNOS SEOUL 2010
  • Place of Presentation: SEOUL (LOTTE HOTEL), KOREA
  • Year and Date: 2010-06-16
• [Presentation] 喉頭亜全摘出術Supracricoid laryngectomy術中迅速病理診断の意義 (2010)
  • Author(s): 中山明仁
  • Organizer: 日本頭頸部癌学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-06-10
• [Presentation] Delayed wound infection after supracricoid laryngectomy following failure of high dose radiation (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino Y., Shunsuke M., Hayashi S
  • Organizer: The 4th World Congress of International Federation of Head and Neck Oncologic Societies, IFHNOS 2010
  • Place of Presentation: Lotte Hotel Seoul
• [Presentation] Flaccid neoglottis following supracricoid laryngectomy : laryngoscopic revision assisted by navigation system (2010)
  • Author(s): Nakayama, M., Matsuki, T., Okamoto, M., Seino Y
  • Organizer: The 4th World Voice Congress 2010
  • Place of Presentation: Coex convention center, Seoul
• [Presentation] Delayed wound infection after supracricoid laryngectomy following failure of high dose radiation (2010)
  • Author(s): Nakayama, M., Okamoto, M., Seino Y., Shunsuke M., Hayashi S.
  • Organizer: The 4th World Congress of International Federation of Head and Neck Oncologic Societies, IFHNOS2010
  • Place of Presentation: Lotte Hotel Seoul.
• [Presentation] Flaccid neoglottis following supracricoid laryngectomy : laryngoscopic revision assisted by navigation system (2010)
  • Author(s): Nakayama, M., Matsuki, T., Okamoto, M., Seino Y.
  • Organizer: The 4th World Voice Congress 2010
  • Place of Presentation: Coex convention center, Seoul.
• [Presentation] 喉頭亜全摘出術における新声門の3次元的解析の試み (2009)
  • Author(s): 中山明仁
  • Organizer: 第54回日本音声言語医学会
  • Place of Presentation: 福島県福島市
  • Year and Date: 2009-10-16
• [Presentation] Supracricoid laryngectomy60症例から学んだこと (2009)
  • Author(s): 中山明仁
  • Organizer: 栃木県頭頸部癌講演会
  • Place of Presentation: 栃木県宇都宮市
  • Year and Date: 2009-07-09
• [Presentation] Clinicopathological analyses of 50 supracricoid laryngectomized specimens : evidence base supporting minimal margins (2009)
  • Author(s): NAKAYAMA MEIJIN
  • Organizer: AAO-HNS Annual meeting
  • Place of Presentation: アメリカ・サンデイエゴ
• [Presentation] 高度な合併症を伴う頭頚部進行癌症例の治療適応 : 症例報告 (2009)
  • Author(s): 清野由輩, 中山明仁, 他
  • Organizer: 第19回日本頭頚部外科学会
  • Place of Presentation: 名古屋東急ホテル
• [Presentation] 高速デジタル撮影による喉頭亜全摘術後声門の解析 : 症例報告 (2009)
  • Author(s): 林 政一, 中山明仁, 他
  • Organizer: 第21回日本喉頭科学会
  • Place of Presentation: 前橋テルサ
• [Presentation] Clinical impact of introducing supracricoid laryngectomy the CHEP to treat glottic cancers : experience on 41 patients. (2008)
  • Author(s): NAKAYAMA MEIJIN
  • Organizer: 7^<th> International Conference on Head and Neck Cancer
  • Place of Presentation: Sanfrancisco Marriott
• [Book] Atlas of Head and Neck Surgery (2011)
  • Author(s): Nakayama, M
  • Publisher: Elsevier Saunders
• [Book] Atlas of Head and Neck Surgery, Commentary on Chapter 36 (2011)
  • Author(s): Meijin Nakayama
  • Total Pages: 4
  • Publisher: Elsevier Saunders
• [Book] EBM耳鼻咽喉科・頭頸部外科の治療-喉頭亜全摘出術のEBMとは? (2010)
  • Author(s): 中山明仁、岡本牧人
  • Publisher: 中外医学社