Diabetic retinopathy (DMR)and Vasohibin

• Project/Area Number: 20592030
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tohoku University
• Principal Investigator: ISHIKAWA YUMI Tohoku University, 大学院・医学系・研究科, 技術補佐員 (60396439)
• Co-Investigator(Kenkyū-buntansha): ABE Toshiaki 東北大学, 大学院・医学系研究科, 教授 (90191858)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: バゾヒビン / 糖尿病 / 網膜症 / 血漿 / 血管内皮細胞増殖因子(VEGF) / HIF / バソヒビン

Research Abstract

I examined vasohibin whether or not it works as marker for treatment of diabetic retinopathy (DMR) or as the possibility of new drug. Vasohibin in plasma was not correlated with retinopathy, however it was lower as the stronger the retinopathy. Retinal pigment epithelial cell transduced with HRE-directed EGFP expression vector showed positive correlation between VEGF and EGFP expression when I added intra-ocular fluids of patients in the medium. Patients with DMR had some factors that induced HIF.

Research Products

• [Journal Article] Vasohibin-1 and retinal pigment epithelium. (2011)
  • Author(s): Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe
  • Journal Title: Adv Med Exp Biol (in press)
  • Peer Reviewed
• [Journal Article] Exploring the role of HSP70 in retinal detachment. (2011)
  • Author(s): Maki Kayama, Toru Nakazawa, Aristomenis Thanos, Yuki Morizane, Yusuke Murakami, Sofia Theodoropoulou, Toshiaki Abe, Demetrios Vavvas, Joan W. Miller
  • Journal Title: Am J Pathol (in press)
  • Peer Reviewed
• [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid) nanoparticles containing dexamethasone. (2011)
  • Author(s): Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
  • Journal Title: J Control Release. 151(1) Pages: 65-73
  • Peer Reviewed
• [Journal Article] A scalable controlled release device for transscleral drug delivery to the retina (2011)
  • Author(s): Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe
  • Journal Title: Biomaterials 32(7) Pages: 1950-1956
  • Peer Reviewed
• [Journal Article] Polymorphisms in ARMS2 (LOC387715) and LOXL1 Genes in Japanese with Age-related Macular Degeneration (2011)
  • Author(s): Nobuo Fuse, MingGe Mengkegale, Akiko Miyazawa, Toshiaki Abe, Toru Nakazawa, Ryosuke Wakusawa, Kohji Nishida
  • Journal Title: AJO 151,(3) Pages: 551-556
  • Peer Reviewed
• [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor (2011)
  • Author(s): Ryosuke Wakusawa, Toshiaki Abe, Hajime Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, et al
  • Journal Title: Invest Ophthalmol Vis Sci Feb 23
  • Peer Reviewed
• [Journal Article] Preoperative factors predictive of postoperative decimal visual acuity ・ 1.0 following surgical treatment for idiopathic epiretinal membrane. (2011)
  • Author(s): Hiroshi Kunikatal, Toshiaki Abe, Jiro Kinukawal, Kohji Nishida
  • Journal Title: Clinical Ophthalmology Feb(5) Pages: 147-154
  • Peer Reviewed
• [Journal Article] A scalable controlled release device for transscleral drug delivery to the retina (2011)
  • Author(s): Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe
  • Journal Title: Biomaterials Volume: 32 Pages: 1950-1956
  • Peer Reviewed
• [Journal Article] Vasohibin-1 and retinal pigment epithelium. (2011)
  • Author(s): Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe
  • Journal Title: Adv Med Exp Biol Volume: 未定(in press)
  • Peer Reviewed
• [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor (2011)
  • Author(s): Ryosuke Wakusawa, Toshiaki Abe, Hajune Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 未定(in press)
  • Peer Reviewed
• [Journal Article] Retinal Pigment Epithehal Cells from Thermally Responsive Polymer-grafted Surface Reduce Apoptosis. (2011)
  • Author(s): Abe T, (1/7)
  • Journal Title: Adv Med Exp Biol Volume: 未定(in press)
  • Peer Reviewed
• [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone. (2010)
  • Author(s): Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
  • Journal Title: J Control Release. Dec 2.(Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Evaluation of retinal degeneration in P27KlP1 null mice. (2010)
  • Author(s): Tokita-Ishikawa Y, Wakusawa R, Abe T
  • Journal Title: Adv Exp Med Biol. 664 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Preparation and characterization of collagen microspheres for sustained release of VEGF. (2010)
  • Author(s): Nagai N, Kumasaka N, Kawashima T, Kaji H, Nishizawa M, Abe T
  • Journal Title: J Mater Sci Mater Med. 21(6) Pages: 1891-1898
  • Peer Reviewed
• [Journal Article] Vogt-小柳-原田病におけるHLA-DRB1*040501検出の頻度 (2010)
  • Author(s): 雪田昌克、阿部俊明、高橋秀肇、大友孝昭、西田幸二
  • Journal Title: あたらしい眼科 27巻1号 Pages: 129-132
  • NAID: 10026924003
  • Peer Reviewed
• [Journal Article] Evaluation of retinal degeneration in P27KIP1 Null Mice (2010)
  • Author(s): Tokita-Ishikawa Y, Wakusawa R, Abe T
  • Journal Title: Adv Exp Med Biol 664 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy. (2009)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Abe T, Shiono T, Iida T, Sakamoto T, Nishida K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol. 247(12) Pages: 1617-24
  • Peer Reviewed
• [Journal Article] Vitreous Levels of Vasohibin-1 and Vascular Endothelial Growth Factor in Patients with Proliferative Diabetic Retinopathy. (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta Sonoda H, Sato Y, Nishida K
  • Journal Title: Diabetologia 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] TrkB-T1 Receptors on Muller Cells Play Critical Role in Brain-Derived Neurotrophic Factor-Mediated Photoreceptor Protection against Phototoxicity (2009)
  • Author(s): Saito T, Abe T, Wakusawa R, Sato H, Asai N, Tokita-Ishikawa Y, Nishida K
  • Journal Title: CURRENT EYE RESEARCH 34(7) Pages: 580-588
  • Peer Reviewed
• [Journal Article] TrkB-T1 receptors on Muller cells play critical role in brain-derived nerve trophic factor-derived photoreceptor protection against phototoxicity (2009)
  • Author(s): Saito T, Abe T, Wakusawa R, Sato H, Asai H, Tokita-Ishikawa Y, Nishida K
  • Journal Title: Curr Eye Res 34 Pages: 580-588
  • Peer Reviewed
• [Journal Article] Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy (2009)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Abe T, Shiono T, Iida T, Sakamoto T, Nishida K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247 Pages: 1617-1624
  • Peer Reviewed
• [Journal Article] Vitreous Levels of Vasohibin-1 and Vascular Endothelial Growth Factor in Patients with Proliferative Diabetic Retinopathy (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta Sonoda H, Sato Y, Nishida K
  • Journal Title: Diabetologia 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] Expression of vasohibin, an antiangiogenic factor, in human choroidal neovascular membranes (2008)
  • Author(s): Wakusawa R, Abe T, Sato H, Yoshida M, Kunikata H, Sato Y, Nishida K
  • Journal Title: Am J Ophthalmol 146 Pages: 235-243
  • Peer Reviewed
• [Journal Article] トリアムシノロンアセトニド併用光線力学療法が視感度と脈絡膜循環に与える影響 (2008)
  • Author(s): 涌澤亮介, 佐藤肇, 吉田まどか, 阿部俊明, 國方彦志, 宮沢弘史, 玉井洋, 西田幸二
  • Journal Title: 臨床眼科 62 Pages: 1355-1360
  • Peer Reviewed
• [Presentation] A novel membrane-based drug delivery capsule for retinalneuroprotection (2010)
  • Author(s): N Nagai, T Kawashima, N Kumasaka, H Kaji, M Nishizawa, T Abe
  • Organizer: Pacifichem 2010
  • Place of Presentation: Hawaii, USA
• [Presentation] 徐放制御性に優れたPEGカプセルの作製と網膜DDSへの応用 (2010)
  • Author(s): 熊坂典浩、永井展裕、川島丈明、梶弘和、大浪英之、西澤松彦、阿部俊明
  • Organizer: 第32回日本バイオマテリアル学会大会
  • Place of Presentation: 広島
• [Presentation] Vasohibin-1 and retinal pigment epithelium. (2010)
  • Author(s): Yumi Ishikawa, Nobuhiro Nagai, Hideyuki Onami, Norihiro Kumasaka, Ryosuke Wakusawa, Hikaru Sonoda, Yasufumi Sato, Toshiaki Abe
  • Organizer: RD2010
  • Place of Presentation: Quebec, Canada
• [Presentation] コラーゲンとポリエチレングリコール複合体からなる薬物徐放制御に優れたカプセルDDSの作製 (2010)
  • Author(s): 永井展裕、川島丈明、梶弘和、熊坂典浩、西澤松彦、阿部俊明
  • Organizer: 第26回DDS学会
  • Place of Presentation: 大阪
• [Presentation] マウス脈絡膜新生血管モデルに対する血管増殖抑制因子バソヒビン遺伝子発現の検討 (2010)
  • Author(s): 大浪英之、涌澤亮介、阿部俊明、佐藤靖史、西田幸二
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 網膜変性疾患治療を目指したコラーゲン微粒子/ポリエチレングリコール複合体からなる薬剤徐放カプセルの作製と評価 (2010)
  • Author(s): 永井展裕、川島丈明、梶弘和、熊坂典浩、西澤松彦、阿部俊明
  • Organizer: 第9回再生医療学会総会
  • Place of Presentation: 広島
• [Presentation] コラーゲン微粒子/ポリエチレングリコール複合体を用いた薬剤徐放カプセルの作製と評価 (2009)
  • Author(s): 川島丈明、永井展裕、梶弘和、西澤松彦、阿部俊明
  • Organizer: 第31回日本バイオマテリアル学会
  • Place of Presentation: 京都
• [Presentation] 加齢黄斑変性におけるLOXL1遺伝子の解析 (2009)
  • Author(s): 宮澤晃子、布施昇男、中澤徹、涌沢亮介、阿部俊明、西田幸二
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Preparation of neurotrophic factor gene expressing collagen devise for retinal diseases (2009)
  • Author(s): Toshiaki Abe、Yumi Ishikawa、Ryosuke Wakusawa、Hideyuki Onami、Nobuhiro Nagai
  • Organizer: ASGT
  • Place of Presentation: San Diego・アメリカ合衆国
• [Presentation] ベーチェット病による難治性網膜ぶどう膜炎に対するInfliximab治療効果の検討 (2008)
  • Author(s): 高橋秀肇, 大友孝昭, 阿部俊明, 西田幸二
  • Organizer: スリーサム(第42回日本眼炎症学会)
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-07-05
• [Presentation] 原田病の診断におけるHLA-DRB1 040501検出の有用性 (2008)
  • Author(s): 雪田昌克, 高橋秀肇, 大友孝昭, 阿部俊明, 西田幸二
  • Organizer: スリーサム(第42回日本眼炎症学会)
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2008-07-05
• [Presentation] Vasohibinと糖尿病網膜症の関係 (2008)
  • Author(s): 阿部俊明
  • Organizer: バゾヒビン研究会
  • Place of Presentation: 大阪彩都
  • Year and Date: 2008-06-18
• [Presentation] 高度近視を伴うAMDに対するPDTと抗VEGF抗体硝子体投与短期的治療効果の比較 (2008)
  • Author(s): 涌澤亮介, 佐藤肇, 阿部俊明, 吉田まどか, 國方彦志, 宮澤弘史, 西田幸二
  • Organizer: 第1回リトリート大学院研究発表
  • Place of Presentation: 東北大学片平キャンパスさくらホール
  • Year and Date: 2008-02-16
• [Presentation] マウス脈絡膜新生血管モデルに対する血管増殖抑制因子vasohibinの抑制効果 (2008)
  • Author(s): 涌澤亮介, 阿部俊明, 佐藤靖史, 西田幸二
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 網膜静脈分枝閉塞に対する治療別成績の比較検討 (2008)
  • Author(s): 志村雅彦、安田佳奈子、塩野貴、中澤徹、阿部俊明、西田幸二、坂本泰二
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 増殖糖尿病網膜症の汎網膜光凝固後に原田病を発症した一例 (2008)
  • Author(s): 雪田昌克、大友孝昭、高橋秀肇、阿部俊明、西田幸二
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 黄斑前膜に対する25ゲージ硝子体手術の治療成績 (2008)
  • Author(s): 國方彦志、鬼怒川次郎、大友孝昭、西郷陽子、涌澤亮介、宮澤弘史、阿部俊明、西田幸二
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ベバシズマブ併用光線力学療法の短期治療効果 (2008)
  • Author(s): 涌澤亮介, 阿部俊明, 國方彦志, 宮澤弘史, 鬼怒川次郎, 西田幸二
  • Organizer: 第62回日本臨床眼科学会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] ポリープ状脈絡膜血管症と増殖糖尿病網膜症を併発した1例 (2008)
  • Author(s): 涌澤亮介、何部俊明、佐藤肇、吉田まどか、國方彦志、宮澤弘史、西田幸二
  • Organizer: 第46回北日本眼科学会
  • Place of Presentation: 盛岡市民文化ホール
• [Presentation] 網膜静脈分枝閉塞に伴う黄斑浮腫に対する抗VEGF抗体・光凝固併用療法 (2008)
  • Author(s): 涌澤亮介, 阿部俊明, 國方彦志, 宮澤弘史, 鬼怒川次郎, 西郷陽子, 西田幸二
  • Organizer: 第47回日本網膜硝子体学会総会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 増殖糖尿病網膜症患者における硝子体中vasohibin-1とVEGF
  • Author(s): 佐藤肇、阿部俊明、涌澤亮介、浅井信晴、國方彦志、太田英樹、園田光、佐藤靖史、西田幸二
• [Presentation] マウス脈絡膜新生血管モデルに対する血管増殖抑制因子vasohibinの抑制効果
  • Author(s): 大浪英之、阿部俊明、涌澤亮介、佐藤靖史,西田幸二
• [Presentation] 網膜静脈分枝閉塞に伴う黄斑浮腫に対する抗VEGF 抗体・光凝固併用療法
  • Author(s): 涌澤亮介(東北大学)、阿部俊明、國方彦志,宮澤弘史、鬼怒川次郎、西郷陽子、西田幸二
• [Remarks] ホームページ等
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• [Patent(Industrial Property Rights)] 持続性ドラックデリバリーシステム (2010)
  • Inventor(s): 阿部俊明
  • Industrial Property Rights Holder: 阿部俊明
  • Filing Date: 2010-08-10
• [Patent(Industrial Property Rights)] 持続性ドラッグデリバリーシステム (2010)
  • Inventor(s): 阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2010-08-10