Pathological clarification of glaucoma by structural and functional evaluation of retinal nerve fiber layer defects

• Project/Area Number: 20592034
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kanazawa University
• Principal Investigator: OHKUBO Shinji Kanazawa University, 附属病院, 助教 (90362003)
• Co-Investigator(Renkei-kenkyūsha): SUGIYAMA Kazuhisa 金沢大学, 医学系, 教授 (80179168) ; HIGASHIDE Tomomi 金沢大学, 附属病院, 講師 (20291370)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 極早期緑内障 / 網膜神経線維層欠損 / 光干渉断層計 / 視野

Research Abstract

We evaluated structure and function of glaucoma subjects with localized retinal nerve fiber layer defects not accompanied by a perimetric defect according to standard automated perimetry (pre-perimetric glaucoma). Fundus-oriented small-target perimetry was a useful method to detect visual field abnormalities in pre-perimetric glaucoma. The relationship of structure and function of the retinal nerve fiber layer defect was clarified by using fundus-oriented perimetry and optical coherence tomography. Deep defect parts and shallow defect parts are present in a retinal nerve fiber layer defect and it became clear that there was visual field sensitivity depression in the deep defect part of the retinal nerve fiber layer defect.

Research Products

• [Journal Article] Evaluation of macular thickness and peripapillary retinal nerve fiber layer thickness for detection of early glaucoma using pectral domain optical coherence tomography. (2011)
  • Author(s): Nakatani Y, Higashide T, Ohkubo S, Takeda H, Sugiyama K
  • Journal Title: J Glaucoma 20 Pages: 252-259
  • Peer Reviewed
• [Journal Article] Does the Enlargement of Retinal Nerve Fiber Layer Defects Relate to Disc Hemorrhage or Progressive Visual Field Loss in Normal-tension Glaucoma (2011)
  • Author(s): Nitta K, Sugiyama K, Higashide T, Ohkubo S, Tanahashi T, Kitazawa Y.
  • Journal Title: J Glaucoma 20 Pages: 189-195
  • Peer Reviewed
• [Journal Article] Does the Enlargement of Retinal Nerve Fiber Layer Defects Relate to Disc Hemorrhage or Progressive Visual Field Loss in Normal-tension Glaucoma (2011)
  • Author(s): Nitta K, Sugiyama K, Higashide T, Ohkubo S, Tanahashi T, Kitazawa Y
  • Journal Title: J Glaucoma Volume: 20 Pages: 189-195
  • Peer Reviewed
• [Journal Article] Peripapillary retinal nerve fiber layer thickness determined by spectral-domain optical coherence tomography in ophthalmologically normal eyes. (2010)
  • Author(s): Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, Sugiyama K, Ootani T, Kishi S, Matsushita K, Maeda N, Hangai M, Yoshimura N.
  • Journal Title: Arch Ophthalmol 128 Pages: 1420-1426
  • Peer Reviewed
• [Journal Article] Peripapillary retinal nerve fiber layer thickness determined byspectral-domain optical coherence tomography in ophthalmologically normaleyes. (2010)
  • Author(s): Hirasawa H, Tomidokoro A, Araie M, Konno S, Saito H, Iwase A, Shirakashi M, Abe H, Ohkubo S, et al
  • Journal Title: Arch Ophthalmol Volume: 128 Pages: 1420-1426
  • Peer Reviewed
• [Journal Article] EVALUATION OF MACULAR THICKNESS AND PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS FOR DETECTION OF EARLY GLAUCOMA USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY (2010)
  • Author(s): Nakatani Y, Higashide T, Ohkubo S, Takeda H, Sugiyama K
  • Journal Title: J Glaucoma (In press)
  • Peer Reviewed
• [Journal Article] In Vivo Quantitative Evaluation of Rat Retinal Nerve Fiber Layer Using Optical Coherence Tomography. (2009)
  • Author(s): Nagata A, Higashide T, Ohkubo S, Takeda H, Sugiyama K.
  • Journal Title: Invest Ophthalmol Vis Sci. 50 Pages: 2809-2815
  • Peer Reviewed
• [Journal Article] In Vivo Quantitative Evaluation of Rat Retinal Nerve Fiber Layer Using Optical Coherence Tomography. (2009)
  • Author(s): Nagata A, Higashide T, Ohkubo S, Takeda H, Sugiyama K
  • Journal Title: Invest Ophthalmol Vis Sci (Epub ahead of print)
  • Peer Reviewed
• [Presentation] Preperimetric glaucomaにおける2種の光干渉断層計による網膜神経線維層欠損の検出能. (2010)
  • Author(s): 大久保真司, 東出朋巳, 武田久, 川口千晶, 杉山和久
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: ポートピアホテル(兵庫県)
  • Year and Date: 2010-11-12
• [Presentation] Preperimetric glaucomaにおける2種の光干渉断層計による網膜神経線維層欠損の検出能 (2010)
  • Author(s): 大久保真司
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: ポートピアホテル(兵庫県)
  • Year and Date: 2010-11-12
• [Presentation] In vivo Evaluation of Thickness Changes of Retinal Layers after Intravitreal Injection of Endothelin-1 in Rat Eye. (2010)
  • Author(s): Tomomi Higashide, Atsushi Nagata, Masatsugu Nakamura, Naruhiro Ishida, Hisashi Takeda, Shinji Ohkubo, Kazuhisa Sugiyama
  • Organizer: ARVO Annual Meeting 2010
  • Place of Presentation: Fort Lauderdale(U.S.A.)
  • Year and Date: 2010-05-03
• [Presentation] 極早期緑内障における上下半視野での網膜神経線維層厚と中心視野障害の検討 (2010)
  • Author(s): 川口千晶, 大久保真司, 東出朋巳, 武田久, 川口一朗, 中谷雄介, 杉山和久
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2010-04-16
• [Presentation] FDTによるPreperimetric glaucomaの視野異常検出能と網膜神経線維層欠損の関係 (2009)
  • Author(s): 大久保真司, 東出朋巳, 武田久, 杉山和久, 岩瀬愛子
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)
  • Year and Date: 2009-11-14
• [Presentation] FDTによる Preperimetric glaucoma の視野異常検出能と網膜神経線維層欠損の関係 (2009)
  • Author(s): 大久保真司
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター (宜野湾市)
  • Year and Date: 2009-11-14
• [Presentation] Spectral domainOCTの黄斑部網膜厚と乳頭周囲網膜神経線維厚の早期緑内障検出能 (2009)
  • Author(s): 中谷雄介, 大久保真司, 武田久, 東出朋巳, 杉山和久
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡国際会議場(福岡県)
  • Year and Date: 2009-10-11
• [Presentation] Preperimetric glaucomaに対する中心視野検査の視野異常検出能 (2008)
  • Author(s): 中谷雄介, 大久保真司, 東出朋巳, 宇田川さち子, 樋口香里, 杉山和久
  • Organizer: 第62回日本臨床眼科学会(専門別研究会:視野研究会)
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2008-10-23
• [Presentation] コーワAP-6000による眼底像視野検査のPreperimetric glaucomaに対する視野異常検出能 (2008)
  • Author(s): 大久保真司, 東出朋巳, 武田久, 中谷雄介, 岩瀬愛子, 可児一孝 ,杉山和久, 島田賢
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2008-04-17
• [Presentation] 眼底対応小視標視野計による正常人の閾値測定-偏心度と年齢による検討- (2008)
  • Author(s): 中谷雄介, 大久保真司, 東出朋巳, 岩瀬愛子, 可児一孝, 杉山和久
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2008-04-17
• [Presentation] 眼底対応小視標視野計による正常人の閾値測定-偏心度と年齢による検討- (2008)
  • Author(s): 中谷雄介, 大久保真司, 東出朋巳, 岩瀬愛子, 可児一孝, 杉山和久
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-17
• [Presentation] コーワAP-6000による眼底像視野検査のPreperimetric glaucoma に対する視野異常検出能 (2008)
  • Author(s): 大久保真司, 東出朋巳, 武田久, 中谷雄介, 岩瀬愛子, 可児一孝, 杉山和久, 島田賢
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-17