| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We examined the changes of the thickness of retinal nerve fiber layer in rat eyes after optic nerve crush by our optical coherence tomography which was optimized to rat eyes. The thickness value measured by the optical coherence tomography showed good repeatability and reproducibility, and was well correlated with that measured by histology. After introduction of multiple scan averaging and an auto-segmentation program, we disclosed that the thickness of the retinal nerve fiber layer decreases following the decrease in the thickness of the inner retinal layer in rat eyes after an intravitreal injection of endothelin-1.
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