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In vivo quantitative evaluation of optic nerve damage in animal models related to glaucoma by a ultrahigh-resolution optical coherence tomography

Research Project

Project/Area Number 20592035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKanazawa University

Principal Investigator

HIGASHIDE Tomomi  Kanazawa University, 附属病院, 講師 (20291370)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords光干渉断層計 / ラット / 緑内障モデル
Research Abstract

We examined the changes of the thickness of retinal nerve fiber layer in rat eyes after optic nerve crush by our optical coherence tomography which was optimized to rat eyes. The thickness value measured by the optical coherence tomography showed good repeatability and reproducibility, and was well correlated with that measured by histology. After introduction of multiple scan averaging and an auto-segmentation program, we disclosed that the thickness of the retinal nerve fiber layer decreases following the decrease in the thickness of the inner retinal layer in rat eyes after an intravitreal injection of endothelin-1.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results)

  • [Journal Article] Evaluation of Macular Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness for Detection of Early Glaucoma Using Spectral Domain Optical Coherence Tomography.2011

    • Author(s)
      Nakatani Y, Higashide T, 他3名
    • Journal Title

      J Glaucoma 20

      Pages: 252-259

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does the Enlargement of Retinal Nerve Fiber Layer Defects Relate to Disc Hemorrhage or Progressive Visual Field Loss in Normal-tension Glaucoma2011

    • Author(s)
      Nitta K, Sugiyama K, Higashide T, 他3名
    • Journal Title

      J Glaucoma 20

      Pages: 189-195

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unilateral choroidal excavation in the macula detected by spectral-domain optical coherence tomography.2010

    • Author(s)
      Wakabayashi Y, Nishimura A, Higashide T, 他2名
    • Journal Title

      Acta Ophthalmol 88

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome.2010

    • Author(s)
      Okuda T, Higashide T, 他3名
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 248

      Pages: 1199-1202

    • NAID

      120002086393

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterior segment optical coherence tomography findings of reverse pupillary block after scleral-fixated sutured posterior chamber intraocular lens implantation.2009

    • Author(s)
      Higashide T, Shimizu F, 他2名
    • Journal Title

      J Cataract Refract Surg 35

      Pages: 1540-1547

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo quantitative evaluation of the rat retinal nerve fiber layer with optical coherence tomography.2009

    • Author(s)
      Nagata A, Higashide T, 他3名
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 2809-2815

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo quantitative evaluation of the rat retinal nerve fiber layer with optical coherence tomography2009

    • Author(s)
      Nagata A, Higashide T, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 2809-2815

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo Evaluation of Thickness Changes of Retinal Layers After Intravi treal Injection of Endothelin-1 in flat Eye2010

    • Author(s)
      東出朋巳
    • Organizer
      2010 Annual Meeting, The Association for Research in Vision and Ophthalmology(ARVO)
    • Place of Presentation
      Fort Lauderdale, (USA)
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] In vivo Evaluation of Thickness Changes of Retinal Layers After Intravitreal Injection of Endothelin-1 in Rat Eye2010

    • Author(s)
      東出朋巳, 長田敦, 他5名
    • Organizer
      ARVO Annual Meeting 2010
    • Place of Presentation
      Greater Fort Lauderdale/Broward County Convention Center(USA)
    • Year and Date
      2010-05-02
    • Related Report
      2010 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与モデルでの網膜神経線維層厚と神経節細胞数の評価2010

    • Author(s)
      長田敦, 東出朋巳, 他5名
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与モデル網膜の光干渉断層計による生体内定量的評価2009

    • Author(s)
      長田敦, 東出朋巳, 他5名
    • Organizer
      第20回日本緑内障学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県)
    • Year and Date
      2009-11-14
    • Related Report
      2010 Final Research Report
  • [Presentation] ラットエンドセリン硝子体内投与モデル網膜の光干渉断層計による生体内定量的評価2009

    • Author(s)
      長田敦, 東出朋巳, ほか
    • Organizer
      第20回日本緑内障学会
    • Place of Presentation
      沖縄コンベンションセンター (沖縄県 宜野湾市)
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] In vivo quantitative evaluation of rat retinal nerve fiber layer using optical coherence tomography2008

    • Author(s)
      長田敦, 東出朋巳, 他6名
    • Organizer
      ARVO Annual Meeting 2008
    • Place of Presentation
      Greater Fort Lauderdale/Broward County Convention Center(USA)
    • Year and Date
      2008-05-01
    • Related Report
      2010 Final Research Report
  • [Presentation] 光干渉断層計によるラット網膜神経線維層の生体内定量的評価の試み2008

    • Author(s)
      長田敦, 東出朋巳, 他5名
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2008-04-18
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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