The development of methods for detecting early glaucoma using spectral-domain optical coherence tomography

• Project/Area Number: 20592038
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: HANGAI Masanori Kyoto University, 医学研究科, 准教授 (70283687)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Hajime 京都大学, 医学研究科, 助教 (80447953) ; HIROSE Fumitaka 京都大学, 医学研究科, 助教 (70447952) ; NONAKA Atsuyuki 京都大学, 医学研究科, 助教 (40532601) ; AKAGI Tadamichi 京都大学, 医学研究科, 助教 (30580112)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 緑内障 / 光干渉断層計 / 早期発見 / 黄斑 / 網膜神経線維

Research Abstract

In this study, we have demonstrated that 3-dimensional imaging of the retina using spectral-domain optical coherence tomography allows us to detect early glaucoma, particularly preperimetric glaucoma; the thinning of macular ganglion cell layer and retinal nerve fiber layer was revealed, and detection of narrow nerve fiber layer was improved by reducing speckle-noise.

Research Products

• [Journal Article] Three-dimensional imaging of macular inner structures in glaucoma using spectral-domain optical coherence tomography. (2011)
  • Author(s): Kotera Y, Hangai M, Hirose F, Mori S, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci 52 Pages: 1412-21
  • Peer Reviewed
• [Journal Article] Hemispherical focal macular photopic negative response and macular inner retinal thickness in open-angle glaucoma. (2011)
  • Author(s): Nakamura H, Hangai M, Mori S, Hirose F, Yoshimura N.
  • Journal Title: Am J Ophthalmol 151 Pages: 494-506
  • Peer Reviewed
• [Journal Article] Three-dimensional imaging of macular inner structures in glaucoma using spectral-domain optical coherence tomography (2011)
  • Author(s): Kotera Y, Hangai M, Hirose F, Mori S, Yoshimura N
  • Journal Title: Investigative Ophthalmology and Visual Science Volume: 52 Pages: 1412-1421
  • Peer Reviewed
• [Journal Article] Hemispherical focal macular photopic negative response and macular inner retinal thickness in open-angle glaucoma (2011)
  • Author(s): Nakamura H, Hangai M, Mori S, Hirose F, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 151 Pages: 494-506
  • Peer Reviewed
• [Journal Article] Automated layer segmentation of macular OCT images using dual-scale gradient information. (2010)
  • Author(s): Yang Q, Reisman CA, Wang Z, Fukuma Y, Hangai M, Yoshimura N, Tomidokoro A, Araie M, Raza AS, Hood DC, Chan A.
  • Journal Title: Optics Express 18 Pages: 21293-307
  • Peer Reviewed
• [Journal Article] Three-Dimensional Imaging of Macular Retinal Nerve Fiber Layer in Glaucoma Using Spectral-Domain Optical Coherence Tomography. (2010)
  • Author(s): Sakamoto A, Hangai M, Nukada M, Nakanishi H, Mori S, Kotera Y, Inoue R, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci 51 Pages: 5062-70
  • Peer Reviewed
• [Journal Article] Three-dimensional profile of macular retinal thickness in normal Japanese eyes. (2010)
  • Author(s): Ooto S, Hangai M, Sakamoto A, Tomidokoro A, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Takeda H, Sugiyama K, Saito H, Iwase A, Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci. 51 Pages: 465-73
  • Peer Reviewed
• [Journal Article] Spectral-domain Optical Coherence Tomography Measurement of Macular Volume for Diagnosing Glaucoma. (2010)
  • Author(s): Mori S, Hangai M, Sakamoto A, Yoshimura N.
  • Journal Title: J Glaucoma(Inoue R, Hangai M) 19 Pages: 528-34
  • Peer Reviewed
• [Journal Article] Three-dimensional profile of peripapillary retinal nerve fiber layer thickness and its related factors in normal eyes (2010)
  • Author(s): Hirasawa H, Tomidokoro A, Araie M, Konno S, Maeda N, Sugiyama K, Iwase A., Kishi S, Abe H, Hangai M, Yoshimura N
  • Journal Title: Arch Ophhalmol Volume: 128 Pages: 1420-1426
  • Peer Reviewed
• [Journal Article] Three-dimensional imaging of macular retinal nerve fiber layer in glaucoma using spectral-domain optical coherence tomography (2010)
  • Author(s): Atsushi Sakamoto, Masanori Hangai, Masayuki Nukada, Hideo Nakanishi, Satoshi Mori, Yuriko Kotera, Ryo Inoue, Nagahisa Yoshimura
  • Journal Title: Investigative Ophthalmology and Visual Science (印刷中)
  • Peer Reviewed
• [Journal Article] Spectral-domain Optical Coherence Tomography Measurement of Macular Volume for Diagnosing Glaucoma. (2010)
  • Author(s): Mori S, Hangai M, Sakamoto A, Yoshimura N.
  • Journal Title: Journal of Glaucoma (印刷中)
  • Peer Reviewed
• [Journal Article] Three-dimensional profile of macular retinal thickness in normal Japanese eyes. (2010)
  • Author(s): Ooto S, Hangai M, Sakamoto A, Tomidokoro A, Araie M, Otani T, Kishi S, Matsushita K, Maeda N, Shirakashi M, Abe H, Takeda H, Sugiyama K, Saito H, Iwase A, Yoshimura N
  • Journal Title: Investigative Ophthalmology and Visual Science 51 Pages: 465-473
  • Peer Reviewed
• [Journal Article] Three-dimensional high-speed optical coherence tomography imaging of lamina cribrosa in glaucoma. (2009)
  • Author(s): Kotera Y, Nakanishi H, Mori S, Morishita S, Yoshimura N.
  • Journal Title: Ophthalmology 116 Pages: 214-222
  • Peer Reviewed
• [Journal Article] Fixation behavior in advanced stage glaucoma assessed by the MicroPerimeter MP-1. (2009)
  • Author(s): Kameda T, Tanabe T, Hangai M, Ojima T, Aikawa H, Yoshimura N.
  • Journal Title: Jpn J Ophthalmol. 53 Pages: 580-7
  • NAID: 10027202919
  • Peer Reviewed
• [Journal Article] Comparison of spectral domain optical coherence tomography and color photographic imaging of the optic nerve head in management of glaucoma. (2009)
  • Author(s): Kotera Y, Yasuno Y, Hangai M, Inoue R, Makita S, Nakanishi H, Yamanari M, Yoshimura N.
  • Journal Title: Ophthalmic Surg Lasers Imaging. 40 Pages: 255-63
  • Peer Reviewed
• [Journal Article] Detection of localized retinal nerve fiber layer defects in glaucoma using enhanced spectral domain optical coherence tomography.
  • Author(s): Nukada M, Hangai M, Mori S, Nakano N, Nakanishi H, Ohashi-Ikeda H, Nonaka A, Yoshimura N.
  • Journal Title: Ophthalmology in press
  • Peer Reviewed
• [Journal Article] Detection of localized retinal nerve fiber layer defects in glaucoma using enhanced spectral domain optical coherence tomography
  • Author(s): Nukada M, Hangai M, Mori S, Nakano N, Nakanishi H, Ohashi-Ikeda H, Nonaka A, MD, Yoshimura N
  • Journal Title: Ophthalmology Volume: (印刷中)
  • Peer Reviewed
• [Presentation] Preperimetricおよび早期緑内障における 黄斑部網膜神経節細胞層アシンメトリー解析 (2010)
  • Author(s): 中野紀子、板谷正紀、森哲、額田正之、高山弘平、諸岡諭、池田華子、赤木忠道、野中淳之、吉村長久
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25
• [Presentation] スペクトラルドメイン光干渉断層計によるpreperimetric glaucoma患者における短期観察期間での黄斑部網膜内層菲薄化の検出 (2010)
  • Author(s): 森哲、板谷正紀、諸岡諭、中野紀子、高山弘平、額田正之、池田華子、赤木忠道、野中淳之、吉村長久
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25
• [Presentation] スペックルノイズ除去OCTによる視野異常を認めない早期緑内障における網膜神経線維層欠損の検出感度の検討 (2010)
  • Author(s): 額田正之、板谷正紀、森哲、高山弘平、中野紀子、諸岡諭、池田華子、赤木忠道、野中淳之、吉村長久
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25
• [Presentation] シンポジウム「緑内障治療効果の評価」治療における神経線維層評価 (2010)
  • Author(s): 板谷正紀
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-24
• [Presentation] スペクトラルドメイン光干渉断層計(RS-3000)を用いた黄斑外網膜神経節細胞層複合体厚測定 (2010)
  • Author(s): 諸岡諭、板谷正紀、森哲、額田正之、中野紀子、高山弘平、赤木忠道、池田華子、野中淳之、吉村長久
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-24
• [Remarks] ホームページ等
• [Patent(Industrial Property Rights)] 眼科情報処理装置及び眼科検査装置 (2008)
  • Inventor(s): 板谷正紀、吉村長久、黄一駿、名達亮一
  • Industrial Property Rights Holder: 株式会社トプコン
  • Patent Publication Number: 2009-034480
  • Acquisition Date: 2008-05-26