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Reproduction of visual function by electrical stimulation through optic nerve electrode

Research Project

Project/Area Number 20592040
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

SAKAGUCHI Hirokazu  Osaka University, 医学系研究科, 助教 (80379172)

Co-Investigator(Kenkyū-buntansha) KAMEI Motohiro  大阪大学, 医学系研究科, 准教授 (40281125)
TANO Yasuo  大阪大学, 医学系研究科, 教授 (80093433)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords視神経刺激 / 刺激電極 / 網膜色素変性 / 人工視覚 / タンパク / 電気生理学
Research Abstract

We have tried to develop an artificial vision by direct optic nerve electrode and in the clinical trial, some of the patients recognized the improvement of visual function after the electrical stimulation through optic nerve. We could not find the effect of the improvement of visual function with the electrical stimulation in this acute study using rats. We then tried to develop the materials and methods to examine the effect with larger animals in chronic study.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (44 results)

All 2011 2010 2009 2008 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results) Presentation (14 results)

  • [Journal Article] Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry2011

    • Author(s)
      Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K
    • Journal Title

      Invest Ophthalmol Vis Sci 52

      Pages: 927-932

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of cataract in evaluation of macular pigment optical density by autofluorescence spectrometry.2011

    • Author(s)
      Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 52 Pages: 927-932

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure and visual acuity in surgically closed macular holes : spectral-domain optical coherence tomographic analysis2010

    • Author(s)
      Wakabayashi T, Fujiwara M, Sakaguchi H, Kusaka S, Oshima Y
    • Journal Title

      Ophthalmology 117

      Pages: 1815-1824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients2010

    • Author(s)
      Suzuki M, Gomi F, Sawa M, Tsujikawa M, Sakaguchi H
    • Journal Title

      Jpn J Ophthalmol 54

      Pages: 124-128

    • NAID

      10027203715

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery2010

    • Author(s)
      Tominaga A, Oshima Y, Wakabayashi T, Sakaguchi H, Hori Y, Maeda N
    • Journal Title

      Ophthalmology 117

      Pages: 811-817

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Suprachoroidal-Transretinal Stimulation in Rabbit Model of Retinal Degeneration2010

    • Author(s)
      Nishida K, Kamei M, Kondo M, Sakaguchi H, Suzuki M, Fujikado T, Tano Y
    • Journal Title

      Invest Ophthalmol Vis Sci 51

      Pages: 2263-2268

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure and visual acuity in surgically closed macular holes : spectral-domain optical coherence tomographic analysis.2010

    • Author(s)
      Wakabayashi T, Fujiwara M, Sakaguchi H, Kusaka S, Oshima Y.
    • Journal Title

      Ophthalmology.

      Volume: 117 Pages: 1815-1824

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients.2010

    • Author(s)
      Suzuki M, Gomi F, Sawa M, Tsujikawa M, Sakaguchi H.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 54 Pages: 124-128

    • NAID

      10027203715

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery.2010

    • Author(s)
      Tominaga A, Oshima Y, Wakabayashi T, Sakaguchi H, Hori Y, Maeda N.
    • Journal Title

      Ophthalmology.

      Volume: 117 Pages: 811-817

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of suprachoroidal-transretinal stimulation in a rabbit model of retinal degeneration.2010

    • Author(s)
      Nishida K, Kamei M, Kondo M, Sakaguchi H, Suzuki M, Fujikado T, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51 Pages: 2263-2268

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artificial vision by direct optic nerve electrode (AV-DONE) implantation in a blind patient with retinitis pigmentosa2009

    • Author(s)
      Sakaguchi H, Kamei M, Fujikado T, Yonezawa E, Ozawa M, Cecilia-Gonzalez C, Ustariz-Gonzalez O, Quiroz-Mercado H, Tano Y
    • Journal Title

      J Artif Organs 12

      Pages: 206-209

    • NAID

      10025351490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of surgical treatments for central retinal vein occlusion ; RON vs. cannulation of tissue plasminogen activator into the retinal vein2009

    • Author(s)
      Yamamoto T, Kamei M, Sakaguchi H, Oshima Y, Ikuno Y, Gomi F, Ohji M, Tano Y
    • Journal Title

      Retina 29

      Pages: 1167-1174

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks2009

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Sakaguchi H, Tano Y
    • Journal Title

      Am J Ophthalmol 148

      Pages: 584-590

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration2009

    • Author(s)
      Shima C, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Tano Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 247

      Pages: 899-906

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Foveal Microstructure and Visual Acuity after Retinal Detachment Repair Imaging Analysis by Fourier-Domain Optical Coherence Tomography2009

    • Author(s)
      Wakabayashi T, Oshima Y, Fujimoto H, Murakami Y, Sakaguchi H, Kusaka S, Tano Y
    • Journal Title

      Ophthalmology 116

      Pages: 519-528

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Artificial vision by direct optic nerve electrode (AV-DONE) implantation in a blind patient with retinitis pigmentosa2009

    • Author(s)
      Sakaguchi H, Kamei M, Fujikado T, Yonezawa E, Ozawa M, Cecilia-Gonzalez C, Ustariz-Gonzalez O, Quiroz-Mercado H, Tano Y.
    • Journal Title

      J Artif Organs 12

      Pages: 206-209

    • NAID

      10025351490

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of surgical treatments for central retinal vein occlusion ; RON vs. cannulation of tissue plasminogen activator into the retinal vein2009

    • Author(s)
      Yamamoto T, Kamei M, Sakaguchi H, Oshima Y, Ikuno Y, Gomi F, Ohji M, Tano Y.
    • Journal Title

      Retina 29

      Pages: 1167-1174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks2009

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Sakaguchi H, Tano Y.
    • Journal Title

      Am J Ophthalmol 148

      Pages: 584-590

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration2009

    • Author(s)
      Shima C, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Tano Y.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 247

      Pages: 899-906

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure and visual acuity after retinal detachment repair : imaging analysis by Fourier-domain optical coherence tomography2009

    • Author(s)
      Wakabayashi T, Oshima Y, Fujimoto H, Murakami Y, Sakaguchi H, Kusaka S, Tano Y.
    • Journal Title

      Ophthalmology 116

      Pages: 519-528

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal Microstructure and Visual Acuity after Retinal Detachment Repair Imaging Analysis by Fourier-Domain Optical Coherence Tomography.2009

    • Author(s)
      Wakabayashi T, Oshima Y, Fujimoto H, Murakami Y, Sakaguchi H, Kusaka s, Tano Y.
    • Journal Title

      Ophthalmology (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation2008

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Ikuno Y, Sakaguchi H, Sayanagi K, Tano Y
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1236-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema2008

    • Author(s)
      Fang X, Sakaguchi H, Kamei M, Kusaka S, Tano Y
    • Journal Title

      Acta Ophthalmol 86

      Pages: 800-805

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive optics fundus camera to examine localized changes in the photoreceptor layer of the fovea2008

    • Author(s)
      Kitaguchi Y, Fujikado T, Bessho K, Sakaguchi H, Gomi F, Yamaguchi T, Nakazawa N, Mihashi T, Tano Y
    • Journal Title

      Ophthalmology 115

      Pages: 1771-7

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases2008

    • Author(s)
      Wakabayashi T, Oshima Y, Sakaguchi H, Kamei M, Kusaka S, Tano Y
    • Journal Title

      Ophthalmology 115

      Pages: 1571-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases in 41 consecutive cases.2008

    • Author(s)
      Wakabayashi T, Oshima Y, Sakaguchi H,. .. .. .. Kamei M, Kusaka S, Tano Y.
    • Journal Title

      Ophthalmology. 115

      Pages: 1571-80

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adaptive optics fundus camera to examine localized changes in the photoreceptor layer of the fovea.2008

    • Author(s)
      Kitaguchi Y, Fujikado T, Bessho K, Sakaguchi H, Gomi F, Yamaguchi T, Nakazawa N, Mihashi T, Tano Y.
    • Journal Title

      Ophthalmology. 115

      Pages: 1771-7

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of one intravitreal injection of bevacizumab in diabetic macular oedema.2008

    • Author(s)
      Fang X, Sakaguchi H,. .. .. .. Kamei M, Kusaka S, Tano Y.
    • Journal Title

      Acta Ophthalmol. 86

      Pages: 800-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal fundus autofluorescence patterns in myopic choroidal neovascularisation.2008

    • Author(s)
      Sawa M, Gomi F, Tsujikawa M, Ikuno Y, Sakaguchi H, Sayanagi K, Tano Y.
    • Journal Title

      Br J Ophthalmol. 92

      Pages: 1236-40

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Suprachoroidal-Transretinal Stimulation in Rabbit Model of Retinal Degeneration

    • Author(s)
      Nishida K, Kamei M, Kondo M, Sakaguchi H, Suzuki M, Fujikado T, Tano Y.
    • Journal Title

      Invest Ophthalmol Vis Sci. (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脈絡膜上経網膜電気刺激型人工視覚システム体内装置埋植手術2010

    • Author(s)
      坂口裕和、瓶井資弘、西田健太郎、生野恭司、森本壮、貴島晴彦、圓尾知之、小澤素生、古野間邦彦、神田寛行、不二門尚、西田幸二
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Electrophysiological Evaluation of Rabbit Eyes Chronically Implanted With Electrode for Suprachoroidal Transretinal Stimulation2010

    • Author(s)
      K.Nishida, H.Sakaguchi, T.Fujikado, M.Kamei
    • Organizer
      ARVO annual meeting 2010
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] A New Electrode Device for Artificial Vision by Direct Optic Nerve Electrode (AV-DONE)2010

    • Author(s)
      H.Sakaguchi, K.Nishida, C.Cecilia-Gonzalez, Y.Terasawa, R.Velez-Montoya, T.Fujikado, R.Sanchez-Fontan, M.Ozawa, H.Quiroz-Mercado, M.Kamei
    • Organizer
      ARVO annual meeting 2010
    • Place of Presentation
      Fort Lauderdale, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 脈絡膜上経網膜電気刺激型人工視覚および視神経刺激型人工視覚の現状2010

    • Author(s)
      坂口裕和
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] A New Electrode Device for Artificial Vision by Direct Optic Nerve Electrode (AV-DONE)2010

    • Author(s)
      H.Sakaguchi, K.Nishida, C.Cecilia-Gonzalez, Y.Terasawa, R.Velez-Montoya, T.Fujikado, R.Sanchez-Fontan, M.Ozawa, H.Quiroz-Mercado, M.Kamei.
    • Organizer
      ARVO annual meeting 2010
    • Place of Presentation
      Fort Lauderdale, FLアメリカ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Electrophysiological Evaluation of Rabbit Eyes Chronically Implanted With Electrode for Suprachoroidal Transretinal Stimulation2010

    • Author(s)
      K.Nishida, H.Sakaguchi, T.Fujikado, M.Kamei.
    • Organizer
      ARVO annual meeting 2010
    • Place of Presentation
      Fort Lauderdale,FL,アメリカ
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脈絡膜上経網膜電気刺激型人工視覚および視神経刺激型人工視覚の現状2010

    • Author(s)
      坂口裕和
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脈絡膜上経網膜電気刺激において大脳皮質誘発電位に影響を与える因子2009

    • Author(s)
      西田健太郎、坂口裕和、瓶井資弘、田野保雄
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] ArtificialVision with Direct Optic Nerve Electrode (AV-DONE)2008

    • Author(s)
      坂口裕和
    • Organizer
      2008 World Ophthalmology Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-06-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Artificial Vision with Direct Optic Nerve Electrode (AV-DONE)2008

    • Author(s)
      H. Sakaguchi
    • Organizer
      2008 World Ophthalmology Congress
    • Place of Presentation
      Hong Kong
    • Year and Date
      2008-06-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Artificial Vision by Direct Optic Nerve Electrode (AV-DONE) for a Blind Patient With Retinitis Pigmentosa2008

    • Author(s)
      H. Sakaguchi, M. Kamei, ….. .. H. Quiroz-Mercado, Y. Tano.
    • Organizer
      2008 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Suprachoridal-Transretinal stimulation (STS) Generates EEP in a Middle-Sized Animal Model of Retinal Degeneration2008

    • Author(s)
      K. Nishida, M. Kamei, M. ……. Y. Tano.
    • Organizer
      2008 ARVO annual meeting
    • Place of Presentation
      Fort Lauderdale, USA
    • Year and Date
      2008-04-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 人工視覚システムの臨床応用を目指して2008

    • Author(s)
      田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] 中型動物における視細胞傷害モデルの作成2008

    • Author(s)
      西田健太郎, ...田野保雄
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-17
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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