Genetic variants of the Bruch's membrane component molecules in typical age-related macular degeneration and polypoidal choroidal vasculopathy

• Project/Area Number: 20592042
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: HONDA Shigeru Kobe University, 医学部附属病院, 講師 (60283892)
• Co-Investigator(Kenkyū-buntansha): ISHIBASHI Kazuki 神戸大学, 医学部附属病院, 講師 (20324923)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 加齢黄斑変性 / ポリープ状脈絡膜血管症 / 遺伝子多型 / 光線力学療法 / 加齢黄斑変性症 / 補体H因子 / ARMS2 / 補体I因子 / PEDF / SOD2 / RDBP-SKIV2L / エラスチン / CD36

Research Abstract

We found the positive associations of ARMS2/HTRA1, CFH, CFI, RDBP, SKIV2L and CD36 variants with typical age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV) in a Japanese population. We found that elastin gene polymorphism was differently associated between tAMD and PCV. ARMS2/HTRA1 and CFH variants were significantly associated with the outcome of photodynamic therapy.

Research Products

• [Journal Article] The association of ARMS2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, Honda S, Kondo N, Negi A.
  • Journal Title: Mol Vis. 17 Pages: 977-982
• [Journal Article] Positive association of complement factor H gene variants with the effect of photodynamic therapy in polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, Honda S, Kondo N, et al.
  • Journal Title: J Clinic Experiment Ophthalmol. 2 Pages: 122-122
• [Journal Article] Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over one year of follow-up. (2011)
  • Author(s): Bessho H, Honda S, Imai H, Negi A.
  • Journal Title: Retina [Epub ahead of print]
• [Journal Article] Complement Factor H Y402H Variant and Risk of Age-Related Macular Degeneration in Asians : A Systematic Review and Meta-Analysis. (2011)
  • Author(s): Kondo N, Bessho H, Honda S, Negi A.
  • Journal Title: Ophthalmology. 118 Pages: 339-344
• [Journal Article] Complement Factor H Y402H Variant and Risk of Age-Related Macular Degeneration in Asians : A Systematic Review and Meta-Analysis. (2011)
  • Author(s): Kondo N, et al
  • Journal Title: Ophthalmology Volume: 118 Pages: 339-344
  • Peer Reviewed
• [Journal Article] The association of ARMS2 polymorphisms with phenotype in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, et al
  • Journal Title: Molecular Vision Volume: 17(In press)
  • Peer Reviewed
• [Journal Article] Positive association of complement factor H gene variants with the effect of photodynamic therapy in polypoidal choroidal vasculopathy. (2011)
  • Author(s): Bessho H, et al
  • Journal Title: J Clinic Experiment Ophthalmol Volume: 2 Pages: 122-122
  • Peer Reviewed
• [Journal Article] Natural course and funduscopic findings of polypoidal choroidal vasculopathy in a Japanese population over one year of follow-up. (2011)
  • Author(s): Bessho H, et al
  • Journal Title: Retina Volume: 31(In press)
  • Peer Reviewed
• [Journal Article] Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration. (2010)
  • Author(s): Kondo N, Bessho H, Honda S, Negi A.
  • Journal Title: Eur J Hum Genet. 18 Pages: 634-635
• [Journal Article] Positive association of common variants in CD36 with neovascular age-related macular degeneration. (2009)
  • Author(s): Kondo N, Honda S, Kuno S, Negi A.
  • Journal Title: Aging (Albany NY). 1 Pages: 266-274
• [Journal Article] Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy. (2009)
  • Author(s): Kondo N, Honda S, Kuno S, Negi A.
  • Journal Title: Ophthalmology. 116 Pages: 304-310
• [Journal Article] Photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy : a 30-month multicenter study in Hyogo, Japan. (2009)
  • Author(s): Honda S, Kurimoto Y, Kagotani Y, et al.
  • Journal Title: Jpn J Ophthalmol. 53 Pages: 593-597
  • NAID: 10027202961
• [Journal Article] Comparative assessment of photodynamic therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy : a multicenter study in Hyogo prefecture, Japan. (2009)
  • Author(s): Honda S, Imai H, Yamashiro K, et al.
  • Journal Title: Ophthalmologica. 223 Pages: 333-338
• [Journal Article] SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2009)
  • Author(s): Kondo N, Bessho H, Honda S, Negi A.
  • Journal Title: Mol Vis. 15 Pages: 1819-1826
• [Journal Article] Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology. (2009)
  • Author(s): Kondo N, Honda S, Kuno S, Negi A.
  • Journal Title: Ophthalmology. 116 Pages: 1502-1509
• [Journal Article] Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2009)
  • Author(s): Bessho H, Kondo N, Honda S, et al.
  • Journal Title: Mol Vis. 15 Pages: 1107-1114
• [Journal Article] Role of RDBP and SKIV2L variants in the major histocompatibility complex class III region in polypoidal choroidal vasculopathy etiology. (2009)
  • Author(s): Kondo N, et al
  • Journal Title: Ophthalmology 116 Pages: 1502-1509
  • Peer Reviewed
• [Journal Article] Coding variant Met72Thr in the PEDF gene and risk of neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2009)
  • Author(s): Bessho H, et al
  • Journal Title: Molecular Vision 15 Pages: 1107-1114
  • Peer Reviewed
• [Journal Article] SOD2 gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2009)
  • Author(s): Kondo N, et al
  • Journal Title: Molecular Vision 15 Pages: 1819-1826
  • Peer Reviewed
• [Journal Article] Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy. (2009)
  • Author(s): Kondo N, et al
  • Journal Title: Ophthalmology 116 Pages: 304-310
  • Peer Reviewed
• [Journal Article] Positive association of common variants in CD36 with neovascular age - related macular degeneration (2009)
  • Author(s): Kondo N, et al
  • Journal Title: Aging 1 Pages: 266-274
  • Peer Reviewed
• [Journal Article] Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2008)
  • Author(s): Kondo N, Honda S, Ishibashi K, et al.
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 1101-1105
• [Journal Article] Elastin gene polymorphisms in neovascular age-related macular degeneration and polypoidal choroidal vasculopathy. (2008)
  • Author(s): Kondo N, et al
  • Journal Title: Invest Ophthalmol Vis Sci. 49 Pages: 1101-1105
  • Peer Reviewed
• [Journal Article] Early responses to intravitreal ranibizumab in typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.
  • Author(s): Matsumiya W, Honda S, Bessho H, et al.
  • Journal Title: J Ophthalmol. in press
• [Presentation] 滲出型加齢黄斑変性の表現形および光線力学療法への反応性に関連する遺伝子多型の探索と個別化医療への応用 (2011)
  • Author(s): 本田茂, 他
  • Organizer: 厚生労働省難治政疾患克服研究事業網脈絡膜・視神経萎縮症調査研究班 班会議
  • Place of Presentation: 名古屋市立大学病棟・中央診療棟3F大ホール(愛知県)
  • Year and Date: 2011-01-22
• [Presentation] 近未来の加齢黄斑変性治療を理解するために必要なゲノム学概説加齢黄斑変性と遺伝子多型 (2010)
  • Author(s): 本田茂
  • Organizer: 日本臨床眼科学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2010-11-13
• [Presentation] Genetic characteristics of Polypoidal Choroidal Vasculopathy(PCV)in Japanese population. (2010)
  • Author(s): Honda S
  • Organizer: Macula of Paris
  • Place of Presentation: Paris(フランス)
  • Year and Date: 2010-01-15
• [Presentation] Genetic characteristics of Polypoidal Choroidal Vasculopathy (PCV) in Japanese population. (2010)
  • Author(s): 本田茂
  • Organizer: Macula of Paris
  • Place of Presentation: Paris
• [Presentation] 近未来の加齢黄斑変性治療を理解するために必要なゲノム学概説 加齢黄斑変性と遺伝子多型 (2010)
  • Author(s): 本田茂, 他
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
• [Presentation] Positive association of compliment factor H polymorphism with the effect of photodynamic therapy in polypoidal choroidal vasculopathy. (2009)
  • Author(s): Honda S
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: San Francisco(アメリカ)
  • Year and Date: 2009-10-25
• [Presentation] Positive association of compliment factor H polymorphism with the effect of photodynamic therapy in polypoidal choroidal vasculopathy. (2008)
  • Author(s): 本田茂, et al
  • Organizer: AAO
  • Place of Presentation: San Francisco
• [Presentation] ポリープ状脈絡膜血管症の自然経過に対する統計学的検討および光線力学的療法の影響 (2008)
  • Author(s): 本田茂, 他
  • Organizer: 第62回臨床眼科学会
  • Place of Presentation: 東京
• [Book] 眼のサイエンス視覚の不思議(硝子体の液化はどうして起こるのか?) (2010)
  • Author(s): 本田茂
  • Publisher: 文光堂
• [Book] 六訂版家庭医学大全科(光線力学的療法) (2010)
  • Author(s): 本田茂
• [Book] NANO OPHTHALMOLOGY 37巻(特集:加齢黄斑変性治療の展開～光線力学的療法～) (2009)
  • Author(s): 本田茂
• [Book] 眼科プラクティス23巻(トリアムシノロンの投与法と注意点) (2008)
  • Author(s): 本田茂
• [Book] 眼科プラクティス23巻(光感受性物質の投与法と注意点) (2008)
  • Author(s): 本田茂
• [Book] 眼科ケア10巻(徹底解説!網膜剥離) (2008)
  • Author(s): 本田茂
• [Book] 遺伝子多型臨床眼科62巻増刊号(加齢黄斑変性症) (2008)
  • Author(s): 本田茂
• [Remarks] ホームページ等