Genetic variants of the Bruch's membrane component molecules in typical age-related macular degeneration and polypoidal choroidal vasculopathy
| Project/Area Number |
20592042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
HONDA Shigeru Kobe University, 医学部附属病院, 講師 (60283892)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Kazuki 神戸大学, 医学部附属病院, 講師 (20324923)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 加齢黄斑変性 / ポリープ状脈絡膜血管症 / 遺伝子多型 / 光線力学療法 / 加齢黄斑変性症 / 補体H因子 / ARMS2 / 補体I因子 / PEDF / SOD2 / RDBP-SKIV2L / エラスチン / CD36 |
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| Research Abstract |
We found the positive associations of ARMS2/HTRA1, CFH, CFI, RDBP, SKIV2L and CD36 variants with typical age-related macular degeneration (tAMD) and polypoidal choroidal vasculopathy (PCV) in a Japanese population. We found that elastin gene polymorphism was differently associated between tAMD and PCV. ARMS2/HTRA1 and CFH variants were significantly associated with the outcome of photodynamic therapy.
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Report
(4 results)
Research Products
(40 results)
