The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy
| Project/Area Number |
20592043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kobe University |
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Principal Investigator |
NAKAMURA Makoto Kobe University, 医学研究科, 講師 (80273788)
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| Co-Investigator(Kenkyū-buntansha) |
KANAMORI Akiyasu 神戸大学, 医学部附属病院, 助教 (10444572)
NEGI Akira 神戸大学, 大学院・医学研究科・教授 (00189359)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病網膜症 / 網膜神経節細胞 / アポトーシス / アクアポリン / 緑内糖尿病網膜症 / 水チャンネル / グリア細胞 / アストロサイト / 高眼圧 / 網膜神経節細胞死 / 糖尿病乳頭症 / 黄斑浮腫 |
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| Research Abstract |
The association of neurodegeneration with microangiopathy in diabetic retinopathy was investigated. Experimental diabetic rat retinas showed accelerated apoptosis of retinal neurons that coincided with altered expression of glial aquaporin water channels. These findings implicated in the impaired water transport from glia to neurons and vasoproliferative changes induced by diabetes. Optical coherent tomographic analysis of patients with diabetic papillopathy indicated that glial tissues of the optic nerve head may act as the third blood-retinal barrier.
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Report
(4 results)
Research Products
(24 results)
