The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy

• Project/Area Number: 20592043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Kobe University
• Principal Investigator: NAKAMURA Makoto Kobe University, 医学研究科, 講師 (80273788)
• Co-Investigator(Kenkyū-buntansha): KANAMORI Akiyasu 神戸大学, 医学部附属病院, 助教 (10444572) ; NEGI Akira 神戸大学, 大学院・医学研究科・教授 (00189359)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 糖尿病網膜症 / 網膜神経節細胞 / アポトーシス / アクアポリン / 緑内糖尿病網膜症 / 水チャンネル / グリア細胞 / アストロサイト / 高眼圧 / 網膜神経節細胞死 / 糖尿病乳頭症 / 黄斑浮腫

Research Abstract

The association of neurodegeneration with microangiopathy in diabetic retinopathy was investigated. Experimental diabetic rat retinas showed accelerated apoptosis of retinal neurons that coincided with altered expression of glial aquaporin water channels. These findings implicated in the impaired water transport from glia to neurons and vasoproliferative changes induced by diabetes. Optical coherent tomographic analysis of patients with diabetic papillopathy indicated that glial tissues of the optic nerve head may act as the third blood-retinal barrier.

Research Products

• [Journal Article] Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats. (2011)
  • Author(s): Fukuda M, Naka M, Mizokami J, Negi A, Nakamura M.
  • Journal Title: Exp Eye Res 92 Pages: 195-201
  • Peer Reviewed
• [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure. (2010)
  • Author(s): Naka M, Kanamori A, Negi A, Nakamura M.
  • Journal Title: Invest Ophthalmol Vis Sci 51 Pages: 4618-4626
  • Peer Reviewed
• [Journal Article] Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. (2010)
  • Author(s): Fukuda M, Nakanishi Y, Negi A, Nakamura M.
  • Journal Title: Exp Eye Res 90 Pages: 17-25
  • NAID: 120003323950
  • Peer Reviewed
• [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure (2010)
  • Author(s): Maiko Naka
  • Journal Title: Investigative Ophthalmology and Visual Science Volume: 51 Pages: 4618-4626
  • Peer Reviewed
• [Journal Article] Marked cup reversal presumably associated with scleral biomechanics in a case of adult glaucoma. (2010)
  • Author(s): Yoko Kakutani
  • Journal Title: Archives of Ophthalmology 128 Pages: 139-141
  • Peer Reviewed
• [Journal Article] Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. (2010)
  • Author(s): Masahide Fukuda
  • Journal Title: Experimental Eye Research 90 Pages: 17-25
  • Peer Reviewed
• [Journal Article] Serous macular detachment due to diabetic papillopathy detected using optical coherence tomography. (2009)
  • Author(s): Nakamura M, Kanamori A, Negi A.
  • Journal Title: Arch Ophthalmol 127 Pages: 105-107
  • Peer Reviewed
• [Journal Article] Latanoprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo. (2009)
  • Author(s): Kanamori A, Naka M, Fukuda M, Nakamura M, Negi A.
  • Journal Title: Exp Eye Res 88 Pages: 535-541
  • Peer Reviewed
• [Journal Article] Serous macular detachment due to diabetic papillopathy detected using optical coherence tomography. (2009)
  • Author(s): Makoto Nakamura
  • Journal Title: Archives of Ophthalmology 127 Pages: 105-107
  • Peer Reviewed
• [Journal Article] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo. (2008)
  • Author(s): Tatsumi Y, Kanamori A, Negi A, Nakamura M.
  • Journal Title: Curr Eye Res 33 Pages: 683-692
  • Peer Reviewed
• [Journal Article] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo. (2008)
  • Author(s): Yasuko Tatsumi
  • Journal Title: Current Eye Research 33・8 Pages: 683-692
  • Peer Reviewed
• [Journal Article] Disagreement between Heidelberg Retina Tomograph and optical coherence tomography in assessing optic nerve head configuration of eyes with band atrophy and normal eyes. (2008)
  • Author(s): Azusa Nagai-Kusuhara
  • Journal Title: British Journal of Ophthalmology 92・10 Pages: 1382-1386
  • Peer Reviewed
• [Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration. (2008)
  • Author(s): Yusuke Murakami
  • Journal Title: American Journal of Pathology 173・5 Pages: 1326-1338
  • Peer Reviewed
• [Journal Article] Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats
  • Author(s): Masahide Fukuda
  • Journal Title: Experimental Eye Research Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Postural changes in intraocular pressure are associated with asymmetrical retinal nerve fiber thinning in treated patients with primary open-angle glaucoma.
  • Author(s): Junji Mizokami
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: (印刷中)
  • Peer Reviewed
• [Presentation] ラット視神経及び網膜における、挫滅・慢性高眼圧・高血糖の各モデルでのアクアポリンチャンネルの局在 (2010)
  • Author(s): 溝上淳二, 他
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25
• [Presentation] 慢性高眼圧ラット視神経乳頭および網膜のアクアポリン9の局在 (2010)
  • Author(s): 中真衣子, 他
  • Organizer: 第21回日本緑内障学会
  • Place of Presentation: 福岡
  • Year and Date: 2010-09-25
• [Presentation] The role of aquaporin in glaucomatous optic neuropathy. (2010)
  • Author(s): Nakamura M.
  • Organizer: 25^<th> APAO Congress
  • Place of Presentation: 北京
  • Year and Date: 2010-09-18
• [Presentation] The role of aquaporin in glaucomatous optic neuropathy (2010)
  • Author(s): Makoto Nakamura
  • Organizer: 25^<th> APAO Congress
  • Place of Presentation: (中華人民共和国)北京(招待講演)
  • Year and Date: 2010-09-18
• [Presentation] Elevated intraocular pressure reduces aquaporin-9 expression in rat optic nerve head and retina. (2010)
  • Author(s): Nakamura M, 他
  • Organizer: World Ophthalmology Congress 2010
  • Place of Presentation: ベルリン
  • Year and Date: 2010-06-08
• [Presentation] Optical coherence tomographic findings of macular lesions associated with diabetic papillopathy. (2008)
  • Author(s): Nakamura M, 他
  • Organizer: World Ophthalmology Congress 2008
  • Place of Presentation: 香港
  • Year and Date: 2008-06-28
• [Presentation] Optical coherence tomographic findings of macular lesions associated with diabetic papillopathy (2008)
  • Author(s): Makoto Nakamura
  • Organizer: World ophthalmology Congress 2008
  • Place of Presentation: 香港
  • Year and Date: 2008-06-28
• [Presentation] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo. (2008)
  • Author(s): Nakamura M, 他
  • Organizer: World Ophthalmology Congress 2008
  • Place of Presentation: 香港
  • Year and Date: 2008-06-27
• [Remarks] ホームページ等
  • URL: http://www.med.kobe-u.ac.jp/ophthal/index.html