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The effect of retinal neurodegeneration on the development and progression of diabetic retinal microangiopathy

Research Project

Project/Area Number 20592043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKobe University

Principal Investigator

NAKAMURA Makoto  Kobe University, 医学研究科, 講師 (80273788)

Co-Investigator(Kenkyū-buntansha) KANAMORI Akiyasu  神戸大学, 医学部附属病院, 助教 (10444572)
NEGI Akira  神戸大学, 大学院・医学研究科・教授 (00189359)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords糖尿病網膜症 / 網膜神経節細胞 / アポトーシス / アクアポリン / 緑内糖尿病網膜症 / 水チャンネル / グリア細胞 / アストロサイト / 高眼圧 / 網膜神経節細胞死 / 糖尿病乳頭症 / 黄斑浮腫
Research Abstract

The association of neurodegeneration with microangiopathy in diabetic retinopathy was investigated. Experimental diabetic rat retinas showed accelerated apoptosis of retinal neurons that coincided with altered expression of glial aquaporin water channels. These findings implicated in the impaired water transport from glia to neurons and vasoproliferative changes induced by diabetes. Optical coherent tomographic analysis of patients with diabetic papillopathy indicated that glial tissues of the optic nerve head may act as the third blood-retinal barrier.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats.2011

    • Author(s)
      Fukuda M, Naka M, Mizokami J, Negi A, Nakamura M.
    • Journal Title

      Exp Eye Res 92

      Pages: 195-201

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure.2010

    • Author(s)
      Naka M, Kanamori A, Negi A, Nakamura M.
    • Journal Title

      Invest Ophthalmol Vis Sci 51

      Pages: 4618-4626

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats.2010

    • Author(s)
      Fukuda M, Nakanishi Y, Negi A, Nakamura M.
    • Journal Title

      Exp Eye Res 90

      Pages: 17-25

    • NAID

      120003323950

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduced expression of aquaporin-9 in rat optic nerve head and retina following elevated intraocular pressure2010

    • Author(s)
      Maiko Naka
    • Journal Title

      Investigative Ophthalmology and Visual Science

      Volume: 51 Pages: 4618-4626

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marked cup reversal presumably associated with scleral biomechanics in a case of adult glaucoma.2010

    • Author(s)
      Yoko Kakutani
    • Journal Title

      Archives of Ophthalmology 128

      Pages: 139-141

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats.2010

    • Author(s)
      Masahide Fukuda
    • Journal Title

      Experimental Eye Research 90

      Pages: 17-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serous macular detachment due to diabetic papillopathy detected using optical coherence tomography.2009

    • Author(s)
      Nakamura M, Kanamori A, Negi A.
    • Journal Title

      Arch Ophthalmol 127

      Pages: 105-107

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Latanoprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo.2009

    • Author(s)
      Kanamori A, Naka M, Fukuda M, Nakamura M, Negi A.
    • Journal Title

      Exp Eye Res 88

      Pages: 535-541

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serous macular detachment due to diabetic papillopathy detected using optical coherence tomography.2009

    • Author(s)
      Makoto Nakamura
    • Journal Title

      Archives of Ophthalmology 127

      Pages: 105-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo.2008

    • Author(s)
      Tatsumi Y, Kanamori A, Negi A, Nakamura M.
    • Journal Title

      Curr Eye Res 33

      Pages: 683-692

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo.2008

    • Author(s)
      Yasuko Tatsumi
    • Journal Title

      Current Eye Research 33・8

      Pages: 683-692

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disagreement between Heidelberg Retina Tomograph and optical coherence tomography in assessing optic nerve head configuration of eyes with band atrophy and normal eyes.2008

    • Author(s)
      Azusa Nagai-Kusuhara
    • Journal Title

      British Journal of Ophthalmology 92・10

      Pages: 1382-1386

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.2008

    • Author(s)
      Yusuke Murakami
    • Journal Title

      American Journal of Pathology 173・5

      Pages: 1326-1338

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes induces expression of aquaporin-0 in the retinal nerve fibers of spontaneously diabetic Torii rats

    • Author(s)
      Masahide Fukuda
    • Journal Title

      Experimental Eye Research

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postural changes in intraocular pressure are associated with asymmetrical retinal nerve fiber thinning in treated patients with primary open-angle glaucoma.

    • Author(s)
      Junji Mizokami
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラット視神経及び網膜における、挫滅・慢性高眼圧・高血糖の各モデルでのアクアポリンチャンネルの局在2010

    • Author(s)
      溝上淳二, 他
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性高眼圧ラット視神経乳頭および網膜のアクアポリン9の局在2010

    • Author(s)
      中真衣子, 他
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of aquaporin in glaucomatous optic neuropathy.2010

    • Author(s)
      Nakamura M.
    • Organizer
      25^<th> APAO Congress
    • Place of Presentation
      北京
    • Year and Date
      2010-09-18
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of aquaporin in glaucomatous optic neuropathy2010

    • Author(s)
      Makoto Nakamura
    • Organizer
      25^<th> APAO Congress
    • Place of Presentation
      (中華人民共和国)北京(招待講演)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elevated intraocular pressure reduces aquaporin-9 expression in rat optic nerve head and retina.2010

    • Author(s)
      Nakamura M, 他
    • Organizer
      World Ophthalmology Congress 2010
    • Place of Presentation
      ベルリン
    • Year and Date
      2010-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Optical coherence tomographic findings of macular lesions associated with diabetic papillopathy.2008

    • Author(s)
      Nakamura M, 他
    • Organizer
      World Ophthalmology Congress 2008
    • Place of Presentation
      香港
    • Year and Date
      2008-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Optical coherence tomographic findings of macular lesions associated with diabetic papillopathy2008

    • Author(s)
      Makoto Nakamura
    • Organizer
      World ophthalmology Congress 2008
    • Place of Presentation
      香港
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Nipradilol protects rat retinal ganglion cells from apoptosis induced by serum deprivation in vitro and by diabetes in vivo.2008

    • Author(s)
      Nakamura M, 他
    • Organizer
      World Ophthalmology Congress 2008
    • Place of Presentation
      香港
    • Year and Date
      2008-06-27
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.med.kobe-u.ac.jp/ophthal/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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