Role of neural guidance factor on cornal epithelial wound healing.

• Project/Area Number: 20592045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Yamaguchi University
• Principal Investigator: KO Jiae Yamaguchi University, 大学院・医学系研究科, 講師 (70314797)
• Co-Investigator(Kenkyū-buntansha): YANAI Ryoji 山口大学, 大学院・医学系研究科, 講師 (10346554)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 眼細胞生物学 / 再生医学 / 発達・分化 / 細胞・組織

Research Abstract

Semaphorin 3A released from corneal fibroblasts may play an important role in the regulation of intercellular communication between corneal epithelial cells as well as in maintenance of corneal structure, function and wound healing.

Research Products

• [Journal Article] Down-Regulation of Matrix Metalloproteinase-2 in Corneal Fibroblasts by Interleukin-1 Receptor Antagonist Release from Corneal Epithelial (2011)
  • Author(s): Ko J.-A., Yanai R., Chikama TI., Nishida T.
  • Journal Title: Cells.Invest.Ophthalmol.Vis.Sci. in press
  • Peer Reviewed
• [Journal Article] Down-Regulation of Matrix Metalloproteinase-2 in Corneal Fibroblasts by Interleukin-1 Receptor Antagonist Release from Corneal Epithelial Cells. (2011)
  • Author(s): Ko J.-A.
  • Journal Title: Investigative Ophthalmology Visual Science Volume: (in press)
  • Peer Reviewed
• [Journal Article] Expression of semaphoring 3A and its receptors during mouse corneal development. (2010)
  • Author(s): Ko J.-A., Mizuno Y., Yanai R., Chikama TI., Sonoda KH.
  • Journal Title: Biochem.Biophysic.Res.Commun. 403 Pages: 305-309
  • Peer Reviewed
• [Journal Article] Effects of semaphoring 3A overexpression in corneal fibroblasts on the expression of adherens-junction proteins in corneal epithelial cells. (2010)
  • Author(s): Ko J.-A., Akamatsu Y., Yanai R., Nishida T.
  • Journal Title: Biochem.Biophysic.Res.Commun. 396 Pages: 781-786
  • Peer Reviewed
• [Journal Article] Expression of semaphoring 3A in the rat corneal epithelium during wound healing. (2010)
  • Author(s): Morishige N., Ko J.-A., Morita Y. Nishida T.
  • Journal Title: Biochem.Biophysic.Res.Commun. 395 Pages: 451-457
  • Peer Reviewed
• [Journal Article] Expression of semaphorin3A and its receptors during mouse corneal devvelopment. (2010)
  • Author(s): Ko J.-A.
  • Journal Title: Biochemical Biophysical Research Communication Volume: 403 Pages: 305-309
  • Peer Reviewed
• [Journal Article] Effects of semaphorin3A overexpression in corneal fibroblasts on the expression of adherens-junction proteins in corneal epithelial cells. (2010)
  • Author(s): Ko J.-A.
  • Journal Title: Biochemical Biophysical Research Communication Volume: 396 Pages: 781-786
  • Peer Reviewed
• [Journal Article] IGF-1 released by corneal epithelial cells induces up-regulation of N-cadherin in corneal fibroblasts. (2009)
  • Author(s): Ko J.-A., Yanai R., Nishida T.
  • Journal Title: J.Cell Physiol. 221 Pages: 254-261
  • Peer Reviewed
• [Journal Article] Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia. (2009)
  • Author(s): Yanai R
  • Journal Title: Investigative Ophthalmology and Visual Science 50 Pages: 4605-4610
  • Peer Reviewed
• [Journal Article] IGF-1 released by corneal epithelial cells induces up-regulation of N-cad herin in corneal fibroblasts (2009)
  • Author(s): Ko J.-A
  • Journal Title: Journal of Cellular Physiology 211 Pages: 254-261
  • Peer Reviewed
• [Journal Article] Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells. (2009)
  • Author(s): Ko J.-A
  • Journal Title: Cell Biochemistry & Function 27 Pages: 388-394
  • Peer Reviewed
• [Journal Article] Upregulation of ZO-1 in cultured human corneal epithelial cells by a peptide (PHSRN) corresponding to the second cell-binding site of fibronectin. (2009)
  • Author(s): Yanai R
  • Journal Title: Investigative Ophthalmology and Visual Science 50 Pages: 2757-2764
  • Peer Reviewed
• [Journal Article] Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P. (2009)
  • Author(s): Ko J.-A
  • Journal Title: FEBS Letters 583 Pages: 2148-2153
  • Peer Reviewed
• [Journal Article] Upregulation of connexin43 expression in corneal fibroblasts by corneal epithelial cells. (2009)
  • Author(s): Ko J.-A
  • Journal Title: Investigative Ophthalmology and Visual Science 50 Pages: 2054-2060
  • Peer Reviewed
• [Journal Article] Sequence specificity of the PHSRN peptide from fibronectin on cornea epithelial migration. (2009)
  • Author(s): Hattori A
  • Journal Title: Biochemical and Biophysical Research Communica 379 Pages: 346-350
  • Peer Reviewed
• [Journal Article] Up-Regulation of Semaphorin3A in Human Corneal Fibroblasts by Epidermal Growth Factor Released from Cocultured Human Corneal Epithelial Cells. (2008)
  • Author(s): Ko J. -A
  • Journal Title: Biochemical Biophysical Research Communication 377 Pages: 104-108
  • Peer Reviewed
• [Journal Article] Up-regulation of HSP70 by the fibronectin derived peptide PHSRN in human corneal epithelial cells. (2008)
  • Author(s): Ko J. -A
  • Journal Title: Biochemical Biophysical Research Communication 370 Pages: 424-428
  • Peer Reviewed
• [Journal Article] Localization of Semaphorin3A in the rat cornea (2008)
  • Author(s): Morishige N
  • Journal Title: Experimental Eye Research 86 Pages: 669-674
  • Peer Reviewed
• [Presentation] Neural cells promotes the stratification of corneal epithelial cells by coculture system. (2010)
  • Author(s): Ko J.-A., Chikama TI., Sonoda KH.
  • Organizer: 50^<th> The American Society for Cell Biology
  • Place of Presentation: Philadelphia.
  • Year and Date: 2010-12-13
• [Presentation] Neural cells promotes the stratification of corneal epithelial cells by coculture system. (2010)
  • Author(s): Ko J.-A
  • Organizer: The American Society for Cell Biology (50th)
  • Place of Presentation: Philadelphia(Pennsylvania Convention Center)
  • Year and Date: 2010-12-13
• [Presentation] IL-1RA released by corneal epithelial cells induces down-regulation of MMP-2 in cocultured corneal fibroblasts. (2009)
  • Author(s): Ko J.-A., Yanai R., Nishida T.
  • Organizer: 49^<th> The American Society for Cell Biology
  • Place of Presentation: San Diego.
  • Year and Date: 2009-12-06
• [Presentation] IL-1RA released by corneal epithelial cells induces down -regulation of MMP-2 in cocultured corneal fibroblasts. (2009)
  • Author(s): Ko J.-A
  • Organizer: 49^<th> The American Society for Cell Biology
  • Place of Presentation: San Diego Convention Center
  • Year and Date: 2009-12-06
• [Presentation] Semaphorin 3A強発現実質細胞による角膜上皮細胞でのAdherent Junction蛋白質の発現 (2009)
  • Author(s): 高知愛、柳井亮二、森重直行、西田輝夫
  • Organizer: 第113回日本眼科学会総会
  • Year and Date: 2009-04-16
• [Presentation] Semaphorin3A強発現実質細胞による角膜上皮細胞でのAdherent Junction蛋白質の発現 (2009)
  • Author(s): 高知愛
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2009-04-16
• [Presentation] Up-Regulation of Semaphorin 3A in Human Corneal Fibroblasts by Epidermal Growth Factor Released from Cocultured Human Corneal Epithelial Cells. (2008)
  • Author(s): Ko J.-A., Morishige N., Nishida T
  • Organizer: 48^<th> The American Society for Cell Biology
  • Place of Presentation: San Francisco.
  • Year and Date: 2008-12-16
• [Presentation] Up-Regulation of Semaphorin3A in Human Corneal Fibroblasts by Epidermal Growth Factor Released from Cocultured Human Corneal Epithelial Cells (2008)
  • Author(s): Ko J. -A.
  • Organizer: 48^<th> The American Society for Cell Biology
  • Place of Presentation: San Francisco
  • Year and Date: 2008-12-16
• [Presentation] 共培養による角膜実質細胞でのConnexin43, N-cadherin発現に対する角膜上皮細胞の作用 (2008)
  • Author(s): 高知愛、柳井亮二、西田輝夫
  • Organizer: 第55回マトリックス研究会大会
  • Year and Date: 2008-05-30
• [Remarks] ホームページ等
  • URL: http://ds.cc.yamaguchi-u.ac.jp/~eye/