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Development of anti-tumor gene therapy for retinoblastoma using Sendai virus vector and IFNB gene.

Research Project

Project/Area Number 20592047
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKyushu University

Principal Investigator

YOSHIKAWA Hiroshi  Kyushu University, 大学病院, 助教 (00304808)

Co-Investigator(Kenkyū-buntansha) YONEMITSU Yoshikazu  九州大学, 大学院・薬学研究院, 客員教授 (40315065)
園田 康平  山口大学, 医学部, 教授 (10294943)
Co-Investigator(Renkei-kenkyūsha) SONODA Koh-hei  九州大学, 大学病院, 講師 (10294943)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords眼細胞生物学 / 眼腫瘍学 / 網膜芽細胞腫 / 遺伝子治療 / 免疫治療 / SeV / ΛM / 硝子体播種 / ΔM
Research Abstract

We investigated weather anti-tumor gene therapy using M gene deficient Sendai virus vector encoding IFN-β gene (SeV/ΔM-IFN-β) has therapeutic potentials for the treatment of retinoblastoma. Whereas the gene transduction efficiency of SeV/ΔM vector is low in retinoblastoma cell lines, it mediates efficient gene transfer in a retinal pigment epithelium (RPE)-derived cell line. SeV/ΔM-mediated overexpression of IFN-β in RPE suppressed the growth of retinoblastoma cells, suggesting that intraocular IFN-β gene transfer using SeV/ΔM vector may be a useful strategy for preventing tumor growth in retinoblastoma patients.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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