| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
A model of branch retinal vein occlusion was made on Brown Norway rat. After laser photocoagulation (PC), the retinas were observed. In earlyphase (1-3 days), massive exudative retinal detachment was observed. On day 7, the retinal detachment was absorbed completely. Histologically, the PC treated vessels contained numerous aggregated RBCs in early phase. Some vessels showed endothelial gaps. Intravitreal injection of plasmin in rat eyes showed posterior vitreous detachment in 25% (0.01U) to 50% (0.05-0.1U). Pretreatment of plasmin reduced the severity of retinal detachment after PC. Intravitreal injection of bevacizumab in rat eyes caused decreasing of the number of fenestrae in choriocapillaris transiently until 7days after injection.
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