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Effect of enzymatic vitreolysis on the remodeling of the retinal vasculature

Research Project

Project/Area Number 20592048
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionSaga University

Principal Investigator

AKIRA Hirata  Saga University, 医学部, 准教授 (60295144)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsプラスミン / 後部硝子体剥離 / 網膜 / 硝子体 / 網膜静脈閉塞症 / 網膜静脈閉塞 / bevacizumab
Research Abstract

A model of branch retinal vein occlusion was made on Brown Norway rat. After laser photocoagulation (PC), the retinas were observed. In earlyphase (1-3 days), massive exudative retinal detachment was observed. On day 7, the retinal detachment was absorbed completely. Histologically, the PC treated vessels contained numerous aggregated RBCs in early phase. Some vessels showed endothelial gaps. Intravitreal injection of plasmin in rat eyes showed posterior vitreous detachment in 25% (0.01U) to 50% (0.05-0.1U). Pretreatment of plasmin reduced the severity of retinal detachment after PC. Intravitreal injection of bevacizumab in rat eyes caused decreasing of the number of fenestrae in choriocapillaris transiently until 7days after injection.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (16 results)

All 2011 2010 2009 2008 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (3 results)

  • [Journal Article] Occurrence of capsular delamination in the dislocated in-the-bag intraocular lens.2011

    • Author(s)
      Hirata A, Okinami S, Hayashi K.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior capsule relaxing incisions with neodymium : YAG lase for patients at high-risk for anterior capsule contraction.2011

    • Author(s)
      Hayashi K, Yoshida M, Hirata A, Hayashi H.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 37 Pages: 97-103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term change in corneal astigmatism after sutureless cataract surgery.2011

    • Author(s)
      Hayashi K, Hirata A, Manabe SI, Hayashi H.
    • Journal Title

      Am J Ophthalmol

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of progressive hemifacial atrophy. Fluoresceine and indocyanine green angiographic findings.2009

    • Author(s)
      Kawazoe M, Hirata A, Okinami S.
    • Journal Title

      J Pediatr. Ophthalmol. Strabismus 46

      Pages: 56-58

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in choriocapillaris fenestration of rat eyes after intravitreal bevacizumab injection.2009

    • Author(s)
      Shimomura Y, Hirata A, Okinami S.
    • Journal Title

      Graefe's Arch. Clin. Exp. Ophthalmol. 247

      Pages: 1089-1094

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in choriocapillaris fenestration of rat eyes after intravitreal bevacizumab injection.2009

    • Author(s)
      Shimomura Y, Hirata A, Okinami S.
    • Journal Title

      Graefe's Arch.Clin.Exp.Ophthalmol. 247

      Pages: 1089-1094

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in diabetic macular oedema after phacoemulsification surgery.2009

    • Author(s)
      Hayashi K, Iaarashi C, Hirata A, Hayashi H.
    • Journal Title

      Eye (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patching retinal breaks with Seprafilm in experimental rhegmatogenous retinal ddachment of rabbit eyes.2009

    • Author(s)
      Teruya K, Sueda J, Aiai M, Tsunimaru N, Yamakawa R. Hirata A, Hirose T.
    • Journal Title

      Eye (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in choriocapillaris fenestration of rat eyes after intiavilreal bevacizumab iniectioa2009

    • Author(s)
      Shimomura Y, Hirata A, Okinami S.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe retinal atrophy due to retinal and choroidal vascular occlusion secondary to triamcinolone injection into the nasal mucosa.2008

    • Author(s)
      Hirata A, Kubo M, Okinami S.
    • Journal Title

      Jpn J Ophthalmol. 52

      Pages: 510-511

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death afier transient retinal is chemia.2008

    • Author(s)
      Hirata A, Inatani M, Inomata Y, Yonemura N, Kawaji T, et al.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. 246

      Pages: 51-59

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relapse of Vogt-Koyanagi-Harada disease during IFN-α and ribavirin therapy in a case of chronic viral hepatitis C.

    • Author(s)
      Souma M, Hirata A, Takahashi T, Okinami S.
    • Journal Title

      Case Reports in Ophthalmol. in press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Occurrence of capsular delamination in the dislocated in-the-bag intraocular lens.

    • Author(s)
      Hirata A, Okinami S, Hayashi K.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol. In press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 嚢内固定眼内レンズ脱臼例の走査電子顕微鏡的観察2010

    • Author(s)
      平田憲, 沖波聡, 林研
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Capsular delamination in the dislocated in-the-bag intraocular lens revealed by scanning electron microscopy.2009

    • Author(s)
      Hirata A, Okinami S, Hayashi K
    • Organizer
      American Academy of Ophthalmology.
    • Place of Presentation
      San Francisco
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 網膜虚血再灌流モデルラットにおけるBcl-2c経路に対するsiRNAによる神経保護の検討2009

    • Author(s)
      石川慎一郎, 中林條, 平田憲, 岩切亮, 下村由起子, 沖波聡
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-04-16
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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