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The role of neutrophil elastase on the disturbance of retinal microcirculation

Research Project

Project/Area Number 20592053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNagoya City University

Principal Investigator

YOSHIDA Munenori  Nagoya City University, 大学院・医学研究科, 准教授 (60273447)

Co-Investigator(Kenkyū-buntansha) OGURA Yuichiro  名古屋市立大学, 大学院・医学研究科, 教授 (70191963)
SAKURAI Eiji  名古屋市立大学, 大学院・医学研究科, 講師 (30305528)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords網膜微小循環 / 好中球エラスターゼ / 白血球
Research Abstract

The role of neutrophil elastase (NE) on the disturbance of retinal microcirculation was investigated. NE antagonist reduced the uveitis score in endotoxin-induced uveitis (EIU) model. It also suppressed the retinal injury caused by retinal ischemia-reperfusion. The accumulation of leukocytes in the retina was reduced in those models when NE was administrated. NE plays an important roles to increase tissue injury as well as the dynamics of leukocyte in retinal microcirculation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Suppression of laser-induced choroidal neovascularization by nontargeted siRNA.2010

    • Author(s)
      Ashikari M, Tokoro M, Itaya M, Nozaki M, Ogura Y.
    • Journal Title

      Invest Ophthalmol Vis Sci. 51(7)

      Pages: 3820-3824

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo.2010

    • Author(s)
      Hattori T, Matsubara A, Taniguchi K, Ogura Y.
    • Journal Title

      Curr Eye Res. 35

      Pages: 146-154

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of ICAM-1 in retinal and choroidal endothelial cells by plasmid small-interfering RNAs in vivo.2010

    • Author(s)
      Hirano Y, Sakurai E, Matsubara A, Ogura Y.
    • Journal Title

      Invest Ophthalmol Vis Sci. 51

      Pages: 508-515

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pitavastatin attenuates leukocyte-endothelial interactions induced by ischemia-reperfusion injury in the rat retina.2009

    • Author(s)
      Miyaki K, Matsubara A, Nishiwaki A, Tomida K, Morita H, Yoshida M, Ogura Y.
    • Journal Title

      Curr Eye Res. 34

      Pages: 10-17

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Pascal Laser Photocoagulation Induces Less Vegf Expression in Murine Retina Than Conventional Laser Treatment2010

    • Author(s)
      Y.Hirano, A.Ito, M.Nozaki, Y.Ogura
    • Organizer
      ARVO annual meeting, Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2010-05-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Incidence of the Complications After Intravitreal Injections2010

    • Author(s)
      Nagai, Y. Hirano, M. Yoshida, Y. Ogura
    • Organizer
      ARVO annual meeting, Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2010-05-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Pascal laser photocoagulation induces less VEGF expression in murine retina than conventional laser treatment.2010

    • Author(s)
      Hirano Y, Ito A, Nozaki M, Ogura Y
    • Organizer
      ARVO(Annual meeting of the Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      ブロワードコンベンションセンター(米国)
    • Year and Date
      2010-05-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surgical Results of 25 Gauge Vitrectomy for Proliferative Diabetic Retinopathy2010

    • Author(s)
      D. Ozone, Y. Hirano, J. Ueda, T. Yasukawa, M. Yoshida, Y. Ogura
    • Organizer
      ARVO annual meeting, Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2010-05-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Surgical results of 25 gauge vitrectomy for proliferative diabetic retinopathy.2010

    • Author(s)
      Ozone D, Hirano Y, Ueda J, Yasukawa T, Yoshida Y, Ogura Y
    • Organizer
      ARVO(Annual meeting of the Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      ブロワードコンベンションセンター(米国)
    • Year and Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖尿病ラットにおける網膜白血球集積に対するアルドース還元酵素阻害薬の抑制効果2008

    • Author(s)
      服部知明、松原明久、谷口香織、小椋祐一郎
    • Organizer
      第112回日本眼科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-04-18
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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