The role of neutrophil elastase on the disturbance of retinal microcirculation

• Project/Area Number: 20592053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Nagoya City University
• Principal Investigator: YOSHIDA Munenori Nagoya City University, 大学院・医学研究科, 准教授 (60273447)
• Co-Investigator(Kenkyū-buntansha): OGURA Yuichiro 名古屋市立大学, 大学院・医学研究科, 教授 (70191963) ; SAKURAI Eiji 名古屋市立大学, 大学院・医学研究科, 講師 (30305528)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 網膜微小循環 / 好中球エラスターゼ / 白血球

Research Abstract

The role of neutrophil elastase (NE) on the disturbance of retinal microcirculation was investigated. NE antagonist reduced the uveitis score in endotoxin-induced uveitis (EIU) model. It also suppressed the retinal injury caused by retinal ischemia-reperfusion. The accumulation of leukocytes in the retina was reduced in those models when NE was administrated. NE plays an important roles to increase tissue injury as well as the dynamics of leukocyte in retinal microcirculation.

Research Products

• [Journal Article] Suppression of laser-induced choroidal neovascularization by nontargeted siRNA. (2010)
  • Author(s): Ashikari M, Tokoro M, Itaya M, Nozaki M, Ogura Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 51(7) Pages: 3820-3824
  • Peer Reviewed
• [Journal Article] Aldose reductase inhibitor fidarestat attenuates leukocyte-endothelial interactions in experimental diabetic rat retina in vivo. (2010)
  • Author(s): Hattori T, Matsubara A, Taniguchi K, Ogura Y.
  • Journal Title: Curr Eye Res. 35 Pages: 146-154
  • Peer Reviewed
• [Journal Article] Suppression of ICAM-1 in retinal and choroidal endothelial cells by plasmid small-interfering RNAs in vivo. (2010)
  • Author(s): Hirano Y, Sakurai E, Matsubara A, Ogura Y.
  • Journal Title: Invest Ophthalmol Vis Sci. 51 Pages: 508-515
  • Peer Reviewed
• [Journal Article] Pitavastatin attenuates leukocyte-endothelial interactions induced by ischemia-reperfusion injury in the rat retina. (2009)
  • Author(s): Miyaki K, Matsubara A, Nishiwaki A, Tomida K, Morita H, Yoshida M, Ogura Y.
  • Journal Title: Curr Eye Res. 34 Pages: 10-17
  • Peer Reviewed
• [Presentation] Pascal Laser Photocoagulation Induces Less Vegf Expression in Murine Retina Than Conventional Laser Treatment (2010)
  • Author(s): Y.Hirano, A.Ito, M.Nozaki, Y.Ogura
  • Organizer: ARVO annual meeting, Fort Lauderdale
  • Place of Presentation: Florida, USA
  • Year and Date: 2010-05-05
• [Presentation] Incidence of the Complications After Intravitreal Injections (2010)
  • Author(s): Nagai, Y. Hirano, M. Yoshida, Y. Ogura
  • Organizer: ARVO annual meeting, Fort Lauderdale
  • Place of Presentation: Florida, USA
  • Year and Date: 2010-05-05
• [Presentation] Pascal laser photocoagulation induces less VEGF expression in murine retina than conventional laser treatment. (2010)
  • Author(s): Hirano Y, Ito A, Nozaki M, Ogura Y
  • Organizer: ARVO(Annual meeting of the Association for Research in Vision and Ophthalmology)
  • Place of Presentation: ブロワードコンベンションセンター(米国)
  • Year and Date: 2010-05-05
• [Presentation] Surgical Results of 25 Gauge Vitrectomy for Proliferative Diabetic Retinopathy (2010)
  • Author(s): D. Ozone, Y. Hirano, J. Ueda, T. Yasukawa, M. Yoshida, Y. Ogura
  • Organizer: ARVO annual meeting, Fort Lauderdale
  • Place of Presentation: Florida, USA
  • Year and Date: 2010-05-03
• [Presentation] Surgical results of 25 gauge vitrectomy for proliferative diabetic retinopathy. (2010)
  • Author(s): Ozone D, Hirano Y, Ueda J, Yasukawa T, Yoshida Y, Ogura Y
  • Organizer: ARVO(Annual meeting of the Association for Research in Vision and Ophthalmology)
  • Place of Presentation: ブロワードコンベンションセンター(米国)
  • Year and Date: 2010-05-03
• [Presentation] 糖尿病ラットにおける網膜白血球集積に対するアルドース還元酵素阻害薬の抑制効果 (2008)
  • Author(s): 服部知明、松原明久、谷口香織、小椋祐一郎
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-04-18