The role of neutrophil elastase on the disturbance of retinal microcirculation
| Project/Area Number |
20592053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya City University |
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Principal Investigator |
YOSHIDA Munenori Nagoya City University, 大学院・医学研究科, 准教授 (60273447)
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| Co-Investigator(Kenkyū-buntansha) |
OGURA Yuichiro 名古屋市立大学, 大学院・医学研究科, 教授 (70191963)
SAKURAI Eiji 名古屋市立大学, 大学院・医学研究科, 講師 (30305528)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 網膜微小循環 / 好中球エラスターゼ / 白血球 |
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| Research Abstract |
The role of neutrophil elastase (NE) on the disturbance of retinal microcirculation was investigated. NE antagonist reduced the uveitis score in endotoxin-induced uveitis (EIU) model. It also suppressed the retinal injury caused by retinal ischemia-reperfusion. The accumulation of leukocytes in the retina was reduced in those models when NE was administrated. NE plays an important roles to increase tissue injury as well as the dynamics of leukocyte in retinal microcirculation.
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Report
(4 results)
Research Products
(10 results)
