| Project/Area Number |
20592056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
MACHIDA Shigeki Iwate Medical University, 医学部, 准教授 (30285613)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
金子 宗義 岩手医科大学, 医学部, 助教 (80438499)
村井 憲一 岩手医科大学, 医学部, 助教 (40405832)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | 緑内障 / 網膜電図 / 網膜神経節細胞 / 視神経 / 網膜機能 / 動物モデル / 眼科 / ERG / 視神経萎縮 |
|---|
| Research Abstract |
The photopic negative response (PhNR) of the focal electroretinogram (ERG) is driven by retinal ganglion cells. In the present series of studies, we attempt to apply the PhNR of the focal ERG to patients with glaucoma. We found that the PhNR was well correlated the local retinal sensitivity measured by the static visual field test, morphology of the optic nerve head and retinal nerve fiber layer thickness. The sensitivity and specificity to diagnose early glaucoma were 91%. Based on these results, the PhNR of the focal ERG could be a good objective parameter to measure the visual function of glaucoma patients.
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