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Ophthalmological analysis of vitamin C knockout mice

Research Project

Project/Area Number 20592057
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionIwate Medical University

Principal Investigator

KUROSAKA Daijiro  Iwate Medical University, 医学部, 教授 (20215099)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsビタミンC / ノックアウトマウス / 加齢性眼疾患 / 酸化ストレス / 白内障
Research Abstract

(1) In vitamin C knockout mice (SMP30 knockout mice) given the 0.0375 g/L aqueous solution of vitamin C, the lens vitamin C level decreased to approximately 1/3 of that in wild type mice. In vitamin C knockout mice given the 1.5 g/L aqueous solution of vitamin C, the lens vitamin C level was similar to that in wild type mice. Thus, the 2 V vitamin C doses can be viewed as appropriate for achieving V vitamin C deficiency and sufficiency, respectively, in the vitamin C knockout mouse lens.
(2) In SMP30 knockout mice (vitamin C deficiency) group lens opacities induced by UVR-B were significantly more extensive than in SMP30 knockout mice (vitamin C sufficiency) group or in wild type mice group. It was suggested that vitamin C deficiency increases lens susceptibility to UVR-B induced oxidative stress in mice.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] UVBによるSMP30ノックアウトマウス水晶体の変体2009

    • Author(s)
      石川陽平
    • Organizer
      第48回 日本白内障学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2009-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] UVBによるSMP30ノックアウトマウスの水晶体変化2008

    • Author(s)
      石川陽平、橋爪公平、黒坂大次郎、手塚優、岸本成史、西郡秀夫、近藤嘉高、石神昭人、山本直樹
    • Organizer
      第48回日本白内障学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-06-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 光負荷によるSMP30ノックアウトマウスの水晶体変化2008

    • Author(s)
      川陽平、橋爪公平、黒坂大次郎、手塚優、岸本成史、西郡秀夫、近藤嘉高、石神昭人、山本直樹
    • Organizer
      第47回日本白内障学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 光負荷によるSMP30ノックアウトマウス水晶体の変化2008

    • Author(s)
      石川陽平
    • Organizer
      第47回 日本白内障学会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-06-20
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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