Analysis of the onset of ocular chronic graft versus host disease caused by donor-derived fibroblasts and the development of the new therapeutic intervention

• Project/Area Number: 20592058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: OGAWA Yoko Keio University, 医学部, 講師 (30160774)
• Co-Investigator(Kenkyū-buntansha): SHIMMURA Shigeto 慶應義塾大学, 医学部, 准教授 (00235780)
• Co-Investigator(Renkei-kenkyūsha): MATSUZAKI Yumi 慶應義塾大学, 医学部, 准教授 (50338183) ; TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 眼病理学 / 移植片対宿主病 / ドライアイ / 線維化 / 線維芽細胞 / 慢性移植片対宿主病 / 骨髄幹細胞

Research Abstract

To determine whether donor-derived fibroblasts originate from bone marrow, we used an animal model of chronic graft versus host disease (cGVHD). (Zhang Y, J Immunol, 2002)
To examine the cellular sources of donor-derived fibroblasts in cGVHD recipients, we analyzed mesenchymal stem cells (MSC) (Morikawa S, J Exp Med. 2009) and hematopoietic stem cells (HSC) (Matsuzaki Y, Immunity 2004) from bone marrow. We performed the prospective study using freshly isolated MSCs from donor and HSC from recipient. This is a MSC alone mismatched transplantation. In contrast, MSCs from recipients and HSCs from donor used as a syngeneic MSC transplantation.
In mismatched MSC transplantation, mallory staining of lacrimal gland, liver and salivary gland revealed progressive fibrosis, similar to whole bone marrow transplantation. In contrast, excessive fibrotic areas were scarcely detected 3 and 8 weeks after syngeneic MSC transplantation. When GFP B10.D2 mice were used as donors, GFP+MSCs were found residing in cGVHD fibrotic lesion such as the lacrimal gland, skin and intestine. These results suggest that donor MSCs are partially a source of HSP47+fibroblasts in cGVHD fibrotic tissue. In addition, these results suggest that donor MSCs alone are sufficient to induce cGVHD fibrosis.

Research Products

• [Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease. (2011)
  • Author(s): Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K.
  • Journal Title: Mol.Vis.(Corresponding author) 17 Pages: 598-606
  • Peer Reviewed
• [Journal Article] Four cases of corneal perforation in patients with chronic graft-versus-host disease (2011)
  • Author(s): Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
  • Journal Title: Mol Vis Volume: 17 Pages: 598-606
  • Peer Reviewed
• [Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation. (2010)
  • Author(s): Ogawa Y, Shimmura S, Dogru M, Tsubota K.
  • Journal Title: Ocular graft versus host disease. Cornea. 29
  • Peer Reviewed
• [Journal Article] Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. (2010)
  • Author(s): Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K.
  • Journal Title: Bone Marrow Transplant.(Corresponding author) 45 Pages: 1077-1083
  • Peer Reviewed
• [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. (2010)
  • Author(s): Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
  • Journal Title: Bone Marrow Transplant.(Corresponding author) 45 Pages: 565-569
  • Peer Reviewed
• [Journal Article] 総説 造血幹細胞移植後の眼合併症Frontiers in dry eye涙液からみたオキュラーサーフェス (2010)
  • Author(s): 小川葉子
  • Journal Title: Frontiers in dry eye 5 Pages: 22-29
• [Journal Article] Immune processes and pathogenic fibrosis in ocular chronic graft versus host disease and clinical manifestations after allogeneic hematopoietic stem cell transplantation. (2010)
  • Author(s): Ogawa Y, Shimmura S, Dogru M, Tsubota K.
  • Journal Title: Cornea Volume: 29
  • Peer Reviewed
• [Journal Article] Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye. : 2010. (2010)
  • Author(s): Wang Y, Ogawa Y, Dogru M, Tatematsu Y, Uchino M, Kamoi M, Okada N, Okamoto S, Tsubota K
  • Journal Title: Bone Marrow Transplant Volume: 45 Pages: 1077-1083
  • Peer Reviewed
• [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD. (2010)
  • Author(s): Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
  • Journal Title: Bone Marrow Transplant Volume: 45 Pages: 565-569
  • Peer Reviewed
• [Journal Article] The era of antiaging ophthalmology comes of age : antiaging approach for dry eye treatment. (2010)
  • Author(s): Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Nakamura S, Shinmura K, Higuchi A, Kawakita T.
  • Journal Title: Ophthalmic Res Volume: 44 Pages: 146-54
  • Peer Reviewed
• [Journal Article] Calorie restriction : A new therapeutic intervention for age-related dry eye disease in rats. (2010)
  • Author(s): Kawashima M, Kawakita T, Okada N, Ogawa Y, Dogru M, Nakamura S, Nakashima H, Shimmura S, Shinmura K, Tsubota K.
  • Journal Title: Biochem Biophys Res Commun Volume: 397 Pages: 724-728
  • Peer Reviewed
• [Journal Article] Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. (2010)
  • Author(s): Nakamura S, Kinoshita S, Yokoi N, Ogawa Y, Shibuya M, Nakashima H, R.Hisamura R, Imada T, Imagawa T, Uehara M, Shibuya I, Dogru M, Ward S, Tsubota K.
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] TS-1 induces meibomian gland dysfunction. (2010)
  • Author(s): Matsumoto Y, Dogru M, Sato EA, Ibrahim OM, Tatematsu Y, Ogawa Y, Tsubota K.
  • Journal Title: Ophthalmology Volume: 117
  • Peer Reviewed
• [Journal Article] The role of oxidative stress and inflammation in conjunctivochalasis. (2010)
  • Author(s): Ward SK, Wakamatsu TH, Dogru M, Ibrahim OM, Kaido M, Ogawa Y, Matsumoto Y, Igarashi A, Ishida R, Shimazaki J, Schnider C, Negishi K, Katakami C, Tsubota K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 1994-2002
  • Peer Reviewed
• [Journal Article] Topical tranilast for treatment of the early stage of mild dry eye associated with chronic GVHD (2010)
  • Author(s): Ogawa Y, Dogru M, Uchino M, Tatematsu Y, Kamoi M, Yamamoto Y, Ogawa J, Ishida R, Kaido M, Hara S, R, Matsumoto Y, Kawakita T, Tsubota K.
  • Journal Title: Bone Marrow Transplant 45 Pages: 565-569
  • Peer Reviewed
• [Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. (2009)
  • Author(s): Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
  • Journal Title: Am.J.Pathol. 175 Pages: 2372-2381
  • Peer Reviewed
• [Journal Article] Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease. (2009)
  • Author(s): Ban Y, Ogawa Y, Goto E, Uchino M, Terauchi N, Seki M, Nakaya M, Saiki M, Mori T, Okamoto S, Matsumoto Y. Dogru M, Shimazaki J, Tsubota K.
  • Journal Title: Eye.(Corresponding author) 23 Pages: 202-208
  • Peer Reviewed
• [Journal Article] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease (2009)
  • Author(s): Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
  • Journal Title: Am J Pathol 175 Pages: 2372-2381
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 小川葉子
  • Journal Title: 《造血幹細胞移植後合併症へのアプローチ》内科(南江堂) Pages: 297-302
• [Journal Article] (2009)
  • Author(s): 坪田一男, 根岸一乃編, 小川葉子
  • Journal Title: 慶應義塾大学薬学部 薬剤師継続学習通信講座 第IV講座 外来で診る眼科疾患(慶應義塾大学出版会株式会社) Pages: 51-68
• [Journal Article] Tear function and lipid layer alterations in dry eye patients with chronic graft-vs-host disease. (2009)
  • Author(s): Ban Y, Ogawa Y, et al.
  • Journal Title: Eye 23 Pages: 202-208
  • Peer Reviewed
• [Journal Article] Mini-review.Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease. (2008)
  • Author(s): Ogawa Y, Shimmura S, Kuwana M, Yamazaki K, Kawakami Y, Tsubota K.
  • Journal Title: Inflammation and regeneration. 28 Pages: 533-540
  • Peer Reviewed
• [Journal Article] 重症ドライアイの治療Forntiers in Dry Eye. (2008)
  • Author(s): 小川葉子
  • Journal Title: メディカル レビュー社 3 Pages: 43-48
• [Journal Article] Mini-review. Inflammation and pathogenic fibrosis in human ocular chronic graft versus host disease. (2008)
  • Author(s): Ogawa Y. Shimmura S, et al.
  • Journal Title: Inflammation and regeneration 28 Pages: 533-540
  • Peer Reviewed
• [Journal Article] Reduced efficacy of topical corticosteroid in preventing cytarabine-induced kerato-conjunctivitis in patients receiving high dose cytarabine and total body irradiation for allogeneic hematopoietic stem cell transplantation. (2008)
  • Author(s): Mori T, Watanabe M, Kurotori-Sotome T, Ito C, Ogawa Y, Okamoto S., et al. (11^<th> of 16 authors)
  • Journal Title: Bone marrow transplant 42 Pages: 197-199
  • Peer Reviewed
• [Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討 (2011)
  • Author(s): 小川葉子,榛村重人,森川暁,馬渕洋,谷口智憲,鈴木禎史,河上裕,岡野英之,松崎有未,坪田一男
  • Organizer: 角膜カンファランス2011
  • Place of Presentation: 東京
  • Year and Date: 2011-02-18
• [Presentation] 眼慢性移植片対宿主病におけるドナー由来線維芽細胞の細胞源の検討 (2011)
  • Author(s): 小川葉子、榛村重人、森川暁、馬渕洋、谷口智憲、鈴木禎史、河上裕、岡野英之、松崎有未、坪田一男
  • Organizer: 角膜カンファレンス2011
  • Place of Presentation: 東京
  • Year and Date: 2011-02-18
• [Presentation] 生体共焦点顕微鏡による眼慢性GVHD症例のマイボーム腺の観察 (2011)
  • Author(s): 番裕美子、小川葉子、オサマイブラヒム、立松由佳子、鴨居瑞加、内野美樹、谷口紗織、村戸ドール、坪田一男
  • Organizer: 角膜カンファレンス2011
  • Place of Presentation: 東京
  • Year and Date: 2011-02-17
• [Presentation] Symposium 22.Cicatrizing Ocular Surface Diseases.GVHD Dry Eye (2010)
  • Author(s): Ogawa Y
  • Organizer: The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2010-12-03
• [Presentation] Characterization of Meibomian Gland in Patients with Chronic Graft-Versus-Host Disease Related Dry Eye Using in vivo Laser Confocal Microscopy (2010)
  • Author(s): Ban Y, Ogawa Y, Ibrahim, MA.O, Tatematsu Y, Dogru M, Tsubota K
  • Organizer: The 21^<nd> Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2010-12-02
• [Presentation] Lacrimal Punctal Cauterization in the Management of Ocular Chronic Graft-Versus-Host Disease (2010)
  • Author(s): Yaguchi S, Ogawa Y, Kamoi M, Uchino M, Tatematsu Y, Ban Y, Ohba E, Goto E, Tsubota K
  • Organizer: The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
  • Place of Presentation: Kyoto
  • Year and Date: 2010-12-02
• [Presentation] 第6回ドライアイリ サーチアワード受賞講演 Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease. (2010)
  • Author(s): 小川葉子
  • Organizer: オキュラーサーフェス専門別研究会 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-12
• [Presentation] Morohlogic evaluation of meibomian glands in chronic graft-versus-host-disease. (2010)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OMA, Tatematsu Y, Dogru M, Tsubota K.
  • Organizer: 6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-25
• [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease. (2010)
  • Author(s): Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: 6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-24
• [Presentation] Chronically distributed IP3 receptor-mediated Ca^<2+> Signaling in exocrine glands causes Sjogren's syndrome-like autoimmune disease. (2010)
  • Author(s): Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K
  • Organizer: 6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-24
• [Presentation] Keynote Adress ; The tearome : Not Just Hype : Anti-aging approach for the treatment of dry eye. (2010)
  • Author(s): Tsubota K, Kawashima M, Inaba T, Dogru M, Ogawa Y, Namamura S, Shinmura K, Higuchi A, Kawakita T.
  • Organizer: 6^<th> International Conference on the Tear Film & Ocular Surface ; Basic Science and Clinical Relevance.
  • Place of Presentation: Florence, Italy
  • Year and Date: 2010-09-23
• [Presentation] IP3R欠損マウスを用いたシェーグレン症候群の病態解明 (2010)
  • Author(s): 稲葉隆明、久恒智博、佐々木恭正、小川葉子、竹内勤、御子柴克彦、坪田一男
  • Organizer: 第19回シェーグレン症候群学会
  • Place of Presentation: 千葉
  • Year and Date: 2010-09-09
• [Presentation] 眼慢性移殖片対宿主病における上皮間葉転換 (2010)
  • Author(s): 小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
  • Organizer: 第30回炎症再生医学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-05
• [Presentation] シェーグレン症候群眼表面における最新の画像診断技術 (2010)
  • Author(s): 村戸ドール、松本幸裕、若松タイスヒトミ、佐藤エンリケアダン、オサマモハメドアリイブラヒム、小島隆司、海道美奈子、石田玲子、小川葉子、小畑博人、坪田一男
  • Organizer: 第15回シェーグレン症候群セミナー
  • Place of Presentation: 東京
  • Year and Date: 2010-05-22
• [Presentation] Localization of transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization (2010)
  • Author(s): Hirasawa M, Noda K, Suzuki M, Ogawa Y, Ozawa Y, Tsubota K
  • Organizer: ARVO2010
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-06
• [Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease (2010)
  • Author(s): Ogawa,Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: ARVO2010
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-05
• [Presentation] Measurement of telomere length in lacrimal gland tissue sections using quantitative fluorescence in situ hybridization(Q-FISH) (2010)
  • Author(s): Kawashima M, Kawakita T, Maida Y, Kamoi M, Ogawa Y, Matsutomi K, Shimmura S, Tsubota K
  • Organizer: ARVO2010
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-05
• [Presentation] Role of Inositol 1,4,5,-Triphosphate Receptors and Ca^<2+> Signaling in Tear Secretion (2010)
  • Author(s): Inaba T, Hisatsune C, Sasaki Y, Ogawa Y, Mikoshiba K, Tsubota K
  • Organizer: ARVO2010
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-05
• [Presentation] Matrix metalloproteinase(MMP9)is expressed during corneal perforation in chronic graft-versus-host disease (2010)
  • Author(s): Inagaki E, Ogawa Y, Matsumoto Y, Kawakita T, Shimmura S, Tsubota K
  • Organizer: ARVO2010
  • Place of Presentation: Fort Lauderdale, FL, USA
  • Year and Date: 2010-05-02
• [Presentation] ヒト脈絡膜新生血管組織における上皮間葉系移行(EMT)関連転写因子の局在 (2010)
  • Author(s): 平沢学、野田航介、小沢洋子、小川葉子、鈴木美砂、坪田一男、石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-16
• [Presentation] シンポジウム 4 眼表面サイエンスの最前線 眼表面炎症上皮-間葉転換 (2010)
  • Author(s): 小川葉子
  • Organizer: 第114回日本眼科学会総
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-15
• [Presentation] Symposium 22. Cicatrizing ocular surface disease. GVHD dry eye. (2010)
  • Author(s): Ogawa Y.
  • Organizer: The 2nd Asia Cornea Society Biennial Scientific Meeting.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease. (2010)
  • Author(s): Ogawa Y, Shimmura Y, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K
  • Organizer: 6th International Conference on the Tear Film & Ocular Surface ; Basic Sience and Clinical Relevance.
  • Place of Presentation: Florence, Italy
• [Presentation] Morohlogic evaluation of meibomian glands in chronic graft-versus-host disease. (2010)
  • Author(s): Ban Y, Ogawa Y, Ibrahim OMA, Tatematsu Y, Dogru M, Tsubota K.
  • Organizer: 6th International Conference on the Tear Film & Ocular Surface ; Basic Sience and Clinical Relevance.
  • Place of Presentation: Florence, Italy
• [Presentation] Donor fibroblast chimerism in animal model of ocular chronic graft versus host disease. (2010)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: The Association of Research for Vision and Ophthalmology (ARVO) 2010.
  • Place of Presentation: Fort Lauderdale, FL, USA
• [Presentation] Bone marrow mesenchymal stem cells trigger pathogenic fibrosis in chronic graft-versus-host-disease. (2010)
  • Author(s): Ogawa Y, Shimmura S, Morikawa S, Mabuchi Y, Inaba T, Okano H, Matsuzaki Y, Tsubota K.
  • Organizer: Gordon Conference. 1^<st> Biology & Pathobiology of the Cornea.
  • Place of Presentation: Ventura, CA, USA.
• [Presentation] 眼慢性移殖片対宿主病における上皮間葉転換 (2010)
  • Author(s): 小川葉子、榛村重人、川北哲也、吉田悟、河上裕、坪田一男
  • Organizer: 第30回日本炎症再生医学会
• [Presentation] シンポジウム4眼表面サイエンスの最前線 眼表面炎症と上皮-間葉転換 (2010)
  • Author(s): 小川葉子
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋
• [Presentation] Symposium II.Theme Ocular Surface Allergy & Immunology. Immune Processes and Pathogenic Fibrosis in Ocular Chronic Graft versus Host Disease (2009)
  • Author(s): 小川葉子
  • Organizer: The 15^<th> Annual Meeting of Kyoto Cornea Club
  • Place of Presentation: Kyoto
  • Year and Date: 2009-12-05
• [Presentation] 【Theme : Ocular Surface Allergy&Immunology】Immune Processes and Pathogenic Fibrosis in Ocular Chronic Graft versus Host Disease (2009)
  • Author(s): Ogawa Y. Symposium
  • Organizer: The 15th Annual Meeting of Kyoto Cornea Club
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2009-12-04
• [Presentation] Analysis of pathogenic fibrosis in animal model of ocular chornic graft versus host disease. (2009)
  • Author(s): Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
  • Organizer: The 9^<th> world congress of inflammation.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-07-07
• [Presentation] Analysis of pathogenic fibrosis in animal model of ocular chronic graft versus host disease (2009)
  • Author(s): Ogawa Y, Shimmura S, Inaba T, Okano H, Kawakami Y, Tsubota K.
  • Organizer: The 9th WCI : World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-07
• [Presentation] シンポジウム ドライアイの上流のリスクファクター 全身の免疫炎症 (2009)
  • Author(s): 小川葉子
  • Organizer: 第3回箱根ドライアイクラブ
  • Place of Presentation: 箱根
  • Year and Date: 2009-06-19
• [Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析 (2009)
  • Author(s): 小川葉子,榛村重人,稲葉隆明,河上裕,岡野栄之,坪田一男
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Presentation] マウス涙腺慢性移植片対宿主病モデルにおける病的線維化の発症と進展機序の解析 (2009)
  • Author(s): 小川葉子, 榛村重人, 稲葉隆明, 河上裕, 岡野栄之, 坪田一男
  • Organizer: 第113回日本眼科学会総会, 東京
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Presentation] マウス慢性移植片対宿主病における線維化病変の検討 (2009)
  • Author(s): 小川葉子,榛村重人,森川暁,鈴木禎史,稲葉隆明,河上裕,岡野栄之,松崎有未,坪田一男
  • Organizer: 第8回日本再生医療学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-06
• [Presentation] 要望演題4造血幹細胞移植後の眼合併症の診療と治療 (2009)
  • Author(s): 小川葉子
  • Organizer: 第7回九州BMT研究会
  • Place of Presentation: 福岡
  • Year and Date: 2009-02-21
• [Presentation] カロリー制限による加齢性涙液分泌能低下の抑制 (2009)
  • Author(s): 川島素子, 川北哲也, 岡田直子, 小林真也, 小川葉子, 村戸ドール, 榛村重人, 新村健, 坪田一男
  • Organizer: 第33回角膜カンファランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-20
• [Presentation] イノシトール1、4、5三リン酸受容体欠損マウスの涙液分泌と角膜上皮障害 (2009)
  • Author(s): 稲葉隆明, 佐々木恭正, 久恒智博, 小川葉子, 御子柴克彦, 坪田一男
  • Organizer: 第33回角膜カンファランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-20
• [Presentation] ドライアイ旧診断基準と新診断基準の比較 (2009)
  • Author(s): 内野美樹, 村戸ドール, 内野裕一, サマンサワード, 若松タイスヒトミ, オサマイブラヒム, 小川葉子, 横井則彦, 坪田一男
  • Organizer: 第33回角膜カンファランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-20
• [Presentation] Mikulictz病を疑った4例の血清IgG4値、涙腺生検所見、治療経過の比較検討 (2009)
  • Author(s): 平山雅敏, 羽藤晋, 小川葉子, 亀山香織, 海道美奈子, 石田玲子, 榛村重人, 坪田一男
  • Organizer: 第33回角膜カンフアランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-20
• [Presentation] 抗癌剤TS-1^Rによる閉塞性マイボーム腺機能不全 (2009)
  • Author(s): 松本幸裕, 村戸ドール, 佐藤エンリケアダン, オサマイブラヒム, 立松由佳子, 小川葉子, 榛村重人, 坪田一男
  • Organizer: 第33回角膜カンファランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-20
• [Presentation] 角膜輪部上皮未分化細胞の維持とN-cadherinの関係 (2009)
  • Author(s): 比嘉一成, 榛村重人, 加藤直子, 宮下英之, 小川葉子, 川北哲也, 島崎潤, 坪田一男
  • Organizer: 第33回角膜カンファランス
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-19
• [Presentation] 慢性移植片対宿主病の結膜上皮における上皮間葉系移行 (2008)
  • Author(s): 小川葉子,榛村重人,川北哲也,河上裕,岡野栄之,坪田一男
  • Organizer: 第32回角膜カンファランス
  • Place of Presentation: 東京
  • Year and Date: 2008-02-28
• [Presentation] Epithelial-Mesenchymal Transition of Conjunctival Basal Epithelia in Human Chronic Graft versus Host Disease. (2008)
  • Author(s): Ogawa Y, Shimmura S, Kawakita T, Okano H, Kawakami K, Tsubota K.
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO2008), Annual meeting
  • Place of Presentation: Florida, USA.
• [Presentation] Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease.
  • Author(s): Ogawa Y, Shimmura S, Kawakita T, Yoshida S, Kawakami Y, Tsubota K.
  • Organizer: 第6回ドライアイリ サーチアワード受賞講演(Am J Pathol. 2009;175(6):2372-2381.オキュラ-サーフェス専門別研究会 第64回日本臨床眼科学会 神戸平成22年11月12-15日)
• [Book] Frontiers in dry eye涙液からみたオキュラーサーフェス (2010)
  • Author(s): 小川葉子
  • Total Pages: 8
  • Publisher: メディカルレビュー社
• [Book] 日本女医会誌 (2010)
  • Author(s): 小川葉子
  • Total Pages: 3
  • Publisher: 日本女医会
• [Book] 眼科インストラクションコース アレルギー性眼疾患とドライアイ : 重症度別治療法 (2008)
  • Author(s): 小川葉子
  • Publisher: メジカルビュー社
• [Book] Frontiers in Dry Eye (2008)
  • Author(s): 小川葉子
  • Publisher: メディカル レビュー社
• [Book] 患者さんからあびせられる眼科疾患100の質問 (2008)
  • Author(s): 小川葉子
  • Publisher: メディカル レビュー社
• [Remarks] ホームページ等