A Device for Gene Transfer to the Anterior Segment of the Eye Using Anionic Hydrogel Contact Lens
| Project/Area Number |
20592061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
FUJIMAKI Takuro Juntendo University, 医学部, 准教授 (50333042)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Akira 順天堂大学, 医学部, 教授 (90157743)
土至田 宏 順天堂大学, 医学部, 准教授 (00306961)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ソフトコンタクトレンズ / プラスミドDNA / 培養ヒト角膜上皮細胞 / 遺伝子導入 |
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| Research Abstract |
To investigate non-viral device for gene transfer to the anterior segment of the eye using a newly developed anionic hydrogel soft contact lens (SCL). The newly developed SCL which contained imidazolium group and phosphate group in its side chains lens might be one of the efficient devices for non-viral gene transfection to corneal epithelial cells. It is suggested that this SCL could be applied for gene therapy for corneal diseases.
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Report
(4 results)
Research Products
(7 results)
