Pharmacological effect of various Prostaglandin analogues on ciliary artery smooth muscle cells

• Project/Area Number: 20592070
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Akita University
• Principal Investigator: YOSHITOMI Takeshi Akita University, 大学院・医学系研究科, 教授 (60191623)
• Co-Investigator(Kenkyū-buntansha): SATO Noriko 秋田大学, 大学院・医学系研究科, 助教 (60431623)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 緑内障 / 眼循環 / 血管収縮 / 正常眼圧緑内障 / 眼血流 / 血管平滑筋 / 細胞内カルシウム動態 / プロスタグランディン / 毛様動脈 / プロスタグランディン製剤 / 血管弛緩機序 / プロスタグランデン受容体ノックアウトマウス / 抗緑内障治療薬 / FP受容体 / タフルプロスト / 眼平滑筋 / プロスタクランディン製剤 / プロスタクランディン受容体ノックアウトマウス / 高血圧ラット

Research Abstract

Prostaglandin (PG) analogues lower IOP and have been widely used as ocular hypotensive drugs for the treatment of glaucoma. We investigated the effect of this drugs on ocular circulation. Topical PG also increases ocular blood flow measured by the laser speckle method. PG analogues also concentration-dependently relaxed mouse ciliary artery in vitro. This relaxation was also observed in prostanoid FP receptor-deficient mouse ciliary arteries. Thus, we conclude that the PG analogues relaxes ciliary arteries not dependent on prostanoid FP receptors

Research Products

• [Journal Article] Optic Nerve Head Morphology Assessed by Laser Scanning Tomography in Normal Japanese Subjects. (2010)
  • Author(s): Sawada Y, Ishikawa M, Sato N, Yoshitomi T.
  • Journal Title: J Glaucoma (Equb ahead of print)
• [Journal Article] Effects of Acutely Elevated Hydrostatic Pressure in a Rat Ex Vivo Retinal Preparation. (2010)
  • Author(s): Makoto Ishikawa, Yoshitomi T, Charles F. Zorumski, Yukitoshi Izumi
  • Journal Title: IOVS 51(12) Pages: 6414-6423
  • Peer Reviewed
• [Journal Article] Spontaneous closure of a stage 2 macular hole without detachment of the posterior hyaloid. (2010)
  • Author(s): Abe S, Fujiwawa T, Yoshitomi T.
  • Journal Title: Japanese journal of ophthalmology 54(6) Pages: 633-635
  • NAID: 10027666596
  • Peer Reviewed
• [Journal Article] Effects of prostaglandin F(2α) analogues on endothelin-1-induced impairment of rabbit ocular blood flow : Comparison among tafluprost, travoprost, and latanoprost. (2010)
  • Author(s): Kurashima H, Watabe H, Sato N, Abe S, Ishida N, Yoshitomi T.
  • Journal Title: Experimental Eye Research 91(6) Pages: 853-859
  • Peer Reviewed
• [Journal Article] Reduced effects of endothelium derived hyper-polarizing factor in ocular ciliary arteries from spontaneous hypertensive rats. (2010)
  • Author(s): Dong Y., Watabe H., Cui J., Abe S., Sato N., Ishikawa H., Yoshitomi T.
  • Journal Title: Experimental Eye Research 90(2) Pages: 324-329
  • Peer Reviewed
• [Journal Article] Cauterization of Central Cornea Induces Recruitment of Major Histocompatibility Complex Class II+Langerhans Cells From Limbal Basal Epithelium (2010)
  • Author(s): Chen W., Lin H., Dong N., Takaseki S., Liu Z., Yoshitomi T.
  • Journal Title: Cornea 29(1) Pages: 73-79
  • Peer Reviewed
• [Journal Article] Reduced effects of endothelium-derived hyperpolarizing factor in ocular ciliary arteries from spontaneous hypertensive rats. (2010)
  • Author(s): Dong Y, Watabe H, Cui J, Abe S, Sato N, Ishikawa H, Yoshitomi T
  • Journal Title: Experimental Eye Research Volume: 90 Pages: 324-329
  • Peer Reviewed
• [Journal Article] Spontaneous closure of a stage2 macular hole without detachment of the posterior hyaloids. (2010)
  • Author(s): Abe S, Fujiwara T, Yoshitomi T
  • Journal Title: Japanese Journal of Ophthalmology Volume: 54 Pages: 633-635
  • NAID: 10027666596
  • Peer Reviewed
• [Journal Article] Effects of prostaglandin F(2a)analogues on endothelin-1-induced impairment of rabbit ocular blood flow : Comparison among tafluprost, travoprost, and latanoprost. (2010)
  • Author(s): Kurashima H, Watabe H, Sato N, Abe S, Ishida N, Yoshitomi T
  • Journal Title: Experimental Eye Research Volume: 91 Pages: 853-859
  • Peer Reviewed
• [Journal Article] Effects of Acutely Elevated Hydrostatic Pressure in a Rat Ex Vivo Retinal Preparation (2010)
  • Author(s): Ishikawa M, Yoshitomi T, Zorumski CF, Izumi Y
  • Journal Title: Investigative Ophthalmology & Visual Science Volume: 51 Pages: 6414-6423
  • Peer Reviewed
• [Journal Article] Optic Nerve Head Morphology Assessed by Laser Scanning Tomography in_Normal Japanese Subjects. (2010)
  • Author(s): Sawada Y, Ishikawa M, Sato N, Yoshitomi T
  • Journal Title: Journal of Glaucoma Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] 正常人における眼圧と血圧の関係 (2010)
  • Author(s): 澤田有, 石川誠, 佐藤徳子, 吉冨健志
  • Journal Title: 臨床眼科 Volume: 64 Pages: 307-310
  • Peer Reviewed
• [Journal Article] プロスタグランジン製剤を中心とした緑内障治療 (2010)
  • Author(s): 吉冨健志
  • Journal Title: 日本眼科学会雑誌 Volume: 114 Pages: 427-428
  • NAID: 10026391740
• [Journal Article] Temperature-dependent ultrastructural changes in the cone interphotoreceptor matrix. (2009)
  • Author(s): Ishikawa M, Fujiwara T, Yoshitomi T.
  • Journal Title: Jpn J Ophthalmol. 53 Pages: 536-540
  • NAID: 10025865283
  • Peer Reviewed
• [Journal Article] Peripheral T-cell Lymphoma of the Eyelid. (2009)
  • Author(s): Ishikawa M, Watabe H, Hayakawa M, Yoshitomi T.
  • Journal Title: Clinical Ophthalmol. 3 Pages: 527-529
  • Peer Reviewed
• [Journal Article] Effects of brinzolamide vs. timolol as an adjunctive medication to latanoprost on circadian intraocular pressure control in primary open-angle glaucoma Japanese patients. (2009)
  • Author(s): Ishikawa M, Yoshitomi T.
  • Journal Title: Clinical Ophthalmol. 3 Pages: 493-500
  • Peer Reviewed
• [Journal Article] Temperature-dependent ultrastructural changes in the cone interphotoreceptor matrix. (2009)
  • Author(s): Ishikawa M, Fujiwara T, Yoshitomi T.
  • Journal Title: Jpn J Ophthalmol 53 Pages: 536-540
  • NAID: 10025865283
  • Peer Reviewed
• [Journal Article] Peripheral T-cell Lymphoma of the Eyelid. (2009)
  • Author(s): Ishikawa M, Watabe H, Hayakawa M, Yoshitomi T.
  • Journal Title: Clinical Ophthalmol 3 Pages: 527-529
  • Peer Reviewed
• [Journal Article] Effects of brinzolamide vs.timolol as an adjunctive medication to latanoprost on circadian intraocular pressure control in primary open-angle glaucoma Japanese patients. (2009)
  • Author(s): 石川誠, 吉冨健志
  • Journal Title: Clinical Ophthalmol 3 Pages: 493-500
  • Peer Reviewed
• [Journal Article] 緑内障検診におけるHeidelberg Retina Tomograph II(version 3.0) GPSの有用性 (2009)
  • Author(s): 澤田有, 石川誠, 佐藤徳子, 吉冨健志
  • Journal Title: 臨眼 63 Pages: 293-296
  • Peer Reviewed
• [Journal Article] 日常臨床での点眼薬の特徴とコツ:5.緑内障薬 (2009)
  • Author(s): 吉冨健志
  • Journal Title: 眼科 51(2) Pages: 157-163
• [Journal Article] (2009)
  • Author(s): Yoshitomi T, Ishikawa H
  • Journal Title: Action of various neuropeptides on iris smooth muscles(RESEARCH SIGNPOST)
• [Journal Article] (2009)
  • Author(s): 吉冨健志
  • Journal Title: 瞳孔pupil.現代の眼科学改訂第10版(吉田,谷原編集)(金原出版)
• [Journal Article] (2009)
  • Author(s): 吉冨健志
  • Journal Title: 瞳孔疾患.眼科研修ノート(永井,坪田他編集)(診断と治療社)
• [Journal Article] 日常臨床での点眼薬の特徴とコツ : 5.緑内障薬 (2009)
  • Author(s): 吉冨健志
  • Journal Title: 眼科 51 Pages: 157-163
  • Peer Reviewed
• [Journal Article] Relaxing effect of tafluprost on isolated rabbit ciliary. (2008)
  • Author(s): Dong Y , Watabe H , Su G , Ishikawa H , Sato N , Yositomi T.
  • Journal Title: Exp Eye Res. 87 Pages: 251-256
  • Peer Reviewed
• [Journal Article] Relaxing effect of tafluprost on isolated rabbit ciliary artery (2008)
  • Author(s): Dong Y, Watabe H, Su G, Ishikawa H, Sato N, Yoshitomi T
  • Journal Title: Exp Eye Res 87 Pages: 251-256
  • Peer Reviewed
• [Presentation] Glutamate transporters and excitotoxicity after pressure elevation (2010)
  • Author(s): Ishikawa M, Yoshitomi T.
  • Organizer: APJGC : Asia-Pacific Joint Glaucoma Congress
  • Place of Presentation: Taipei International ConventionCenter(Taipei, Taiwan)
  • Year and Date: 2010-12-04
• [Presentation] High reflective band in the retinal outer nuclear layer observed by spectral-domain optical coherence tomography (2010)
  • Author(s): Fujiwara T, Yoshitomi T, Jin D.
  • Organizer: 10^<th>International AMD and Retina Congress
  • Place of Presentation: Lugano congress center(Lugano Switzerland)
  • Year and Date: 2010-10-29
• [Presentation] やさしい緑内障の基礎-緑内障性視神経障害 (2010)
  • Author(s): 吉冨健志
  • Organizer: 第21回日本緑内障学会総会
  • Place of Presentation: アクロス福岡(福岡)
  • Year and Date: 2010-09-25
• [Presentation] データ解析委員会特別セッション-無治療時眼圧が正常平均以下の原発開放隅角緑内障(広義)に関する前向きコホート研究班 (2010)
  • Author(s): 吉冨健志
  • Organizer: 第21回日本緑内障学会総会
  • Place of Presentation: アクロス福岡、(福岡)
  • Year and Date: 2010-09-24
• [Presentation] 各種プロスタグランジン製剤の家兎毛様動脈平滑筋に対する効果 (2010)
  • Author(s): 阿部早苗, 高関早苗, 吉冨健志
  • Organizer: 第21回日本緑内障学会総会
  • Place of Presentation: アクロス福岡(福岡)
  • Year and Date: 2010-09-24
• [Presentation] Involvement of glutamate in retinal degeneration induced by pressure elevation in isolated retina. World Ophthalmology Congress (2010)
  • Author(s): Ishikawa M., Izumi Y., Yoshitomi T
  • Organizer: The Internationales Congress Centrum Berlin
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2010-06-07
• [Presentation] Involvement of glutamate in retinal degeneration induced by pressure elevation in isolated retina (2010)
  • Author(s): Ishikawa M, Izumi Y, Yoshitomi T.
  • Organizer: WOC : World Ophthalmology Congress
  • Place of Presentation: International Congress Centrum (Berlin, Germany)
  • Year and Date: 2010-06-06
• [Presentation] 偽緑内障のアップデート(サブスペシャリティサンデー7「緑内障・視神経症」緑内障・視神経疾患のアップデート) (2010)
  • Author(s): 吉冨健志
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-04-18
• [Presentation] ラットex vivo網膜標本における急性加圧障害とグリア機能の関係 (2010)
  • Author(s): 石川誠, 澤田有, 阿部早苗, 吉冨健志
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-04-15
• [Presentation] 毛様体皺襞部の全周に及ぶ断裂を伴ったアトピー性網膜剥離の一例 (2010)
  • Author(s): 神大介, 藤原聡之, 傳法毅久, 高関早苗, 吉冨健志
  • Organizer: 第33回日本眼科手術学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-01-22
• [Presentation] 下方を含む半周の毛様体解離に対する毛様体縫着術ab interno (2010)
  • Author(s): 阿部早苗, 早川真弘, 神大介, 傳法毅久, 藤原聡之, 吉冨健志
  • Organizer: 第33回日本眼科手術学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-01-22
• [Presentation] 正常眼における視神経乳頭の形状解析 (2009)
  • Author(s): 澤田有, 石川誠, 佐藤徳子, 吉冨健志
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-11-14
• [Presentation] 無治療時眼圧が正常平均以下の原発開放隅角緑内障(広義)に関する前向きコホート研究(シンポジウム) (2009)
  • Author(s): 吉冨健志
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-11-13
• [Presentation] ラットex vivo網膜標本における急性加圧実験の解析 (2009)
  • Author(s): 石川誠, 佐藤徳子, 阿部早苗, 澤田有, 吉冨健志
  • Organizer: 第20回日本緑内障学会
  • Place of Presentation: 沖縄コンベンションセンター(宜野湾市)
  • Year and Date: 2009-11-13
• [Presentation] 健康検診受診者における緑内障有病率と危険因子の解析 (2009)
  • Author(s): 石川誠, 佐藤徳子, 阿部早苗, 澤田有, 吉冨健志
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: マリンメッセ福岡(福岡市)
  • Year and Date: 2009-10-10
• [Presentation] 正常人における眼圧と血圧の関係 (2009)
  • Author(s): 澤田有, 石川誠, 佐藤徳子, 吉冨健志
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: マリンメッセ福岡(福岡市)
  • Year and Date: 2009-10-10
• [Presentation] 水俣病認定患者における長期視野経過 (2009)
  • Author(s): 松井孝子, 阿部早苗, 大谷朝子, 吉冨健志
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡サンパレス(福岡市)
  • Year and Date: 2009-10-09
• [Presentation] The effect of acute elevated hydrostatic pressure on the rat ex vivo eyecup preparation, World Glaucoma Congress (2009)
  • Author(s): Ishikawa M, Izumi Y, Sato, N, Sawada, Y, Abe S, Yoshitomi T
  • Organizer: The Hynes Convention Center
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-09
• [Presentation] The effect of acute elevated hydrostatic pressure on the rat ex vivo eyecup preparation. (2009)
  • Author(s): Ishikawa M, Izumi Y, Sato, N, Sawada, Y, Abe S, Yoshitomi T.
  • Organizer: World Glaucoma Congress
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-09
• [Presentation] The Effects of Prostaglandin Analogues on Intracellular Ca^<2+> Concentrations. (2009)
  • Author(s): Abe S, Watabe H, Takaseki S, Aihara M, Yoshitomi T.
  • Organizer: World Glaucoma Congress
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-09
• [Presentation] ヒト好酸球はeotaxin刺激により血管内皮増殖因子を産生する (2009)
  • Author(s): 早川宏一, 加藤光里, 植木重治, 木原純子, 田名邊雅子, 谷貝朋美, 竹田正秀, 伊藤亘, 萱場広之, 吉冨健志, 茆原順一
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-16
• [Presentation] 家兎毛様動脈におけるROCK阻害薬Y27632およびY39983の効果 (2009)
  • Author(s): 渡部広史, 高関早苗, 吉冨健志
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-16
• [Presentation] 家兎眼血流障害モデルにおけるタフルプロストの持続的な眼血流改善効果 (2009)
  • Author(s): 佐藤徳子, 阿倍早苗, 倉島宏明, 石田成弘, 吉冨健志
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-16
• [Presentation] FPおよびEP3受容体欠損マウス摘出眼動脈への各種PG製剤の薬理学的効果 (2009)
  • Author(s): 阿部早苗, 渡部広史, 相原一, 吉冨健志
  • Organizer: 第113回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-16
• [Presentation] 正常眼圧緑内障 (2009)
  • Author(s): 吉冨健志
  • Organizer: 厚生労働科学研究推進事業費 : 研究事業による発表会
  • Place of Presentation: 秋田
  • Year and Date: 2009-02-01
• [Presentation] Vasodilative Effects of Antiglaucomatous Prostaglandin Analogues, on Isolated Rabbit and Mouse Ciliary Artery(シンポジウム) (2008)
  • Author(s): Yoshitomi T
  • Organizer: Asia Oceanic Glaucoma Society
  • Place of Presentation: Guangzhou, China
  • Year and Date: 2008-12-06
• [Presentation] Vasodilative Effects of Antiglaucomatous Prostaglandin Analogues, onlsolated Rabbit and Mouse Ciliary Artery (2008)
  • Author(s): Yoshitomi T
  • Organizer: 第7回Asia Oceanic Glaucoma Society
  • Place of Presentation: guangzahou
  • Year and Date: 2008-12-06
• [Presentation] Effect of various antiglaucoma drugs on ocular blood flow(シンポジウム) (2008)
  • Author(s): Yoshitomi T
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: HKCEC, Hong Kong, China
  • Year and Date: 2008-06-29
• [Presentation] Vasodilative Effects of Various Prostagland in F2α Derivative (2008)
  • Author(s): Yoshitomi T, Dong Y, Watabe H, Su G, Sato N, Abe S, Ishikawa H
  • Organizer: on Rabbit Ciliary Artery, World Ophthalmology Congress
  • Place of Presentation: HKCEC, Hong Kong, China
  • Year and Date: 2008-06-29
• [Presentation] sensitivity of retinal capillary nonperfusion area associated with branch retinal vein occlusion (2008)
  • Author(s): Fujiwara T, Iida T, Yoshitomi T, Retinal
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: HKCEC, Hong Kong, China
  • Year and Date: 2008-06-29
• [Presentation] Objective visual field by pupil perimetry (2008)
  • Author(s): Abe S, Sato N, Yoshitomi T, Inakagata S
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: HKCEC, Hong Kong, China
  • Year and Date: 2008-06-29
• [Presentation] Effect of various antiglaucoma drugs on ocular blood flow (2008)
  • Author(s): Yoshitomi T
  • Organizer: World Opthalmology Congress 2008
  • Place of Presentation: 香港
  • Year and Date: 2008-06-29
• [Presentation] Vasodilative Effects of Various Prostaglandin F2α Derivative, on Rabbit Ciliary Artery (2008)
  • Author(s): Yoshitomi T, Dong Y, Watabe H, Su G, Sato N, Abe S and
  • Organizer: World Opthalmology Congress 2008
  • Place of Presentation: 香港
  • Year and Date: 2008-06-29
• [Presentation] Vasodilatory effect of antiglaucomatous prostaglandin analogues in isolated rabbit and mouse ciliary arteries (2008)
  • Author(s): Watabe H, Sato N, Takaseki S, Ishikawa H, Yoshitomi T
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: Ft.Lauderdale, FL, USA
  • Year and Date: 2008-04-27
• [Book] Drugs I Cholingergic agents, Medical Treatment of Glaucoma World Glaucoma Association consensus series7 (2010)
  • Author(s): Changwon Kee, Takeshi Yoshitomi, Neeru Gupta
  • Publisher: Kluger Publications
• [Book] I.トラベクレクトミー術後管理,新Eye Surgery Now 3緑内障手術これでバッチリ! (2010)
  • Author(s): 吉冨健志
  • Publisher: メジカルビュー社
• [Book] Medical Treatment of Glaucoma World Glaucoma Association consensusseries7, Drugs I Cholingergic agents. (2010)
  • Author(s): Changwon Kee, Takeshi Yoshitomi, Neeru Gupta
  • Publisher: Kugler Publications
• [Book] Action of various neuropeptides on iris smooth muscles,Neuropeptides in the eye, (2009)
  • Author(s): Yoshitomi T, Ishikawa H
  • Publisher: Research Signpost
• [Book] 瞳孔pupil,現代の眼科学改訂第10版 (2009)
  • Author(s): 吉冨健志
  • Publisher: 金原出版
• [Book] 眼科研修ノート (2009)
  • Author(s): 吉冨健志,瞳孔疾患
  • Publisher: 診断と治療社
• [Book] 緑内障薬-副交感神経刺激薬-,眼科プラクティス23.「眼科薬物治療Ato Z」 (2008)
  • Author(s): 吉冨健志
  • Publisher: 文光堂
• [Book] 術後早期のトラブルへの対処は?浅前房、脈絡剥離への対処-結膜を大事に扱おう-眼科インストラクションコース14「トラベクレクトミー完全マスター」 (2008)
  • Author(s): 吉冨健志
  • Publisher: メジカルビュー社
• [Book] 15mmHg未満で進行する正常眼圧緑内障は、どう管理するのか?,眼科インストラクションコース17「眼科診療のスキルアップ緑内障編」 (2008)
  • Author(s): 吉冨健志
  • Publisher: メジカルビュー社
• [Book] 視野進行判定と治療方針,眼科診療のコツと落とし穴3.検査・診断 (2008)
  • Author(s): 吉冨健志
  • Total Pages: 96
  • Publisher: 中山書店
• [Book] 眼科インストラクションコース14「トラベクレクトミー完全マスター」 (2008)
  • Author(s): 吉冨健志
  • Publisher: メジカルビュー
• [Book] 眼科インストラクションコース17「眼科診療のスキルアップ緑内障編」 (2008)
  • Author(s): 吉冨健志
  • Publisher: メジカルビュー
• [Book] 眼科診療のコツと落とし穴検査・診断 (2008)
  • Author(s): 吉冨健志
  • Publisher: 中山書店
• [Remarks] ホームページ等