Pharmacological effect of various Prostaglandin analogues on ciliary artery smooth muscle cells
| Project/Area Number |
20592070
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Akita University |
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Principal Investigator |
YOSHITOMI Takeshi Akita University, 大学院・医学系研究科, 教授 (60191623)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Noriko 秋田大学, 大学院・医学系研究科, 助教 (60431623)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 緑内障 / 眼循環 / 血管収縮 / 正常眼圧緑内障 / 眼血流 / 血管平滑筋 / 細胞内カルシウム動態 / プロスタグランディン / 毛様動脈 / プロスタグランディン製剤 / 血管弛緩機序 / プロスタグランデン受容体ノックアウトマウス / 抗緑内障治療薬 / FP受容体 / タフルプロスト / 眼平滑筋 / プロスタクランディン製剤 / プロスタクランディン受容体ノックアウトマウス / 高血圧ラット |
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| Research Abstract |
Prostaglandin (PG) analogues lower IOP and have been widely used as ocular hypotensive drugs for the treatment of glaucoma. We investigated the effect of this drugs on ocular circulation. Topical PG also increases ocular blood flow measured by the laser speckle method. PG analogues also concentration-dependently relaxed mouse ciliary artery in vitro. This relaxation was also observed in prostanoid FP receptor-deficient mouse ciliary arteries. Thus, we conclude that the PG analogues relaxes ciliary arteries not dependent on prostanoid FP receptors
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Report
(4 results)
Research Products
(75 results)
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[Journal Article]2009
Author(s)
Yoshitomi T, Ishikawa H
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Journal Title
Action of various neuropeptides on iris smooth muscles(RESEARCH SIGNPOST)
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[Presentation] ヒト好酸球はeotaxin刺激により血管内皮増殖因子を産生する2009
Author(s)
早川宏一, 加藤光里, 植木重治, 木原純子, 田名邊雅子, 谷貝朋美, 竹田正秀, 伊藤亘, 萱場広之, 吉冨健志, 茆原順一
Organizer
第113回日本眼科学会総会
Place of Presentation
東京国際フォーラム(東京都)
Year and Date
2009-04-16
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