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Analysis of mechanisms of protozoan invasion into the retinal endothelium of congenital toxoplasmic retinochoroiditis

Research Project

Project/Area Number 20592071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionChiba University

Principal Investigator

NOROSE Kazumi  Chiba University, 大学院・医学研究院, 助教 (30156244)

Co-Investigator(Kenkyū-buntansha) FURUYA Mitsuko  横浜市立大学, 医学部, 准教授 (10361445)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords眼微生物学 / 感染症学 / トキソプラズマ / ケモカイン / 接着分子 / 感染症 / インターフェロンガンマ / 寄生虫
Research Abstract

We established the model of congenital toxoplasmic retinochoroiditis. The expression of IFN-γ, chemokines and adherence molecules in the retina were extremely high after infection. Thus, IFN-γ, chemokines and adherence molecules have important roles on the mechanisms of pathogenesis of congenital toxoplasmic retinochoroiditis. Toxoplasma gondii was detected in the retina and there were cell infiltration around the retinal vessels showing vasculitis and leakage of fluorescence dye in the retina.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (76 results)

All 2011 2010 2009 2008 Other

All Journal Article (30 results) (of which Peer Reviewed: 28 results) Presentation (42 results) Remarks (4 results)

  • [Journal Article] CXCL10 is required to maintain T cell populations and control parasite replication during chronic ocular toxoplasmosis.2011

    • Author(s)
      Norose K, Kikumura A, Luster AD, Hunter CA, Harris TH.
    • Journal Title

      Invest Ophthalmol Vis Sci 52

      Pages: 389-398

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of skin grafts and organs infected with Toxoplasma gondii as a source of toxoplasmosis in immunocompromised mice2011

    • Author(s)
      Belal US
    • Journal Title

      Jpn.J.Inf.Dis.

      Volume: 64 In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CXCL10 is required to maintain T cell populations and to control parasite replication during chronic ocular toxoplasmosis.2011

    • Author(s)
      Norose K
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 389-398

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death.2010

    • Author(s)
      Oka M, Edamatsu H, Kunisada M, Hu L, Takenaka N, Dien S, Sakaguchi M, Kitazawa R, Norose K, Kataoka T, Nishigori C.
    • Journal Title

      Carcinogenesis. 31(10)

      Pages: 1897-1902

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene.2010

    • Author(s)
      Kikumura A, Fang H, Mun HS, Uemura N, Makino M, Sayama Y, Norose K, Aosai F.
    • Journal Title

      Parasitol Int 59(2)

      Pages: 105-111

    • NAID

      10029823492

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel method for isolating podocytes using magnetic activated cell sorting.2010

    • Author(s)
      Murakami A, Oshiro H, Kanzaki S, Yamaguchi A, Yamanaka S, Furuya M, Miura S, Kanno H, Nagashima Y, Aoki I, Nagahama K.
    • Journal Title

      Nephrol Dial Transplant. 25

      Pages: 3884-3890

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of an activated mammalian target of rapamycin (mTOR) in gastroenteropancreatic neuroendocrine tumors.2010

    • Author(s)
      Shida T, Kishimoto T, Furuya M, Nikaido T, Koda K, Takano S, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Tanizawa T, Nakatani Y, Miyazaki M.
    • Journal Title

      Cancer Chemother Pharmacol. 65

      Pages: 889-893

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 寄生虫の標的臓器別症状からすすめる実地診療-疑い、問診・診断から治療まで一眼科症状 外来を訪れる寄生虫症2010

    • Author(s)
      野呂瀬一美
    • Journal Title

      Medical Practice 27(9)

      Pages: 1515-1518

    • Related Report
      2010 Final Research Report
  • [Journal Article] 腹腔内再発を繰り返した子宮間葉系腫瘍: Perivascular Epithelioid Cell Tumor (PEComa)の一例2010

    • Author(s)
      新野史, 窪田興志, 稲山嘉明, 古屋充子
    • Journal Title

      日本婦人科病理学会誌 1

      Pages: 31-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Birt-Hogg-Dube症候群2010

    • Author(s)
      古賀俊輔, 古屋充子, 中谷行雄
    • Journal Title

      日本臨床 68

      Pages: 361-369

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 寄生虫の標的臓器別症状からすすめる実地診療-疑い、問診・診断から治療まで一眼科症状 外来を訪れる寄生虫症2010

    • Author(s)
      野呂瀬一美
    • Journal Title

      Medical Practice

      Volume: 27 Pages: 1515-1518

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Enhancement of ultraviolet B-induced skin tumor development in phospholipase CE-knockout mice is associated with decreased celldeath.2010

    • Author(s)
      Oka M
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 1897-1902

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective immunity against lethal anaphylactic reaction in Toxoplasmagondii-infected mice by DNA vaccination with T.gondii-derived heat shock protein 70 gene.2010

    • Author(s)
      Kikumura A
    • Journal Title

      Parasitol lnt

      Volume: 59 Pages: 105-111

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung Cysts in Birt-Hogg-Dube Syndrome : Histopathological characteristics and Aberrant Sequence Repeats.2009

    • Author(s)
      Koga S, Furuya M, Takahashi Y, Tanaka R, Yamaguchi A, Yasufuku K, Hiroshima K, Kurihara M, Yoshino I, Aoki I, Nakatani Y.
    • Journal Title

      Pathol Int 59

      Pages: 720-728

    • NAID

      10027381867

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Metastasis of malignant struma ovarii to the lumbar spine.2009

    • Author(s)
      Yamashita M, Ishii T, Ohtori S, Oikawa Y, Watanabe T, Ito T, Furuya M, Takahashi K.
    • Journal Title

      J Clin Neurosci. 17

      Pages: 269-272

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexity of Tumor Vasculature and Microenvironment.2009

    • Author(s)
      Furuya M, Yonemitsu Y, Aoki I.
    • Journal Title

      Curr Pharm Des 15

      Pages: 1854-1867

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 胸壁デスモイドの1切除例2009

    • Author(s)
      荒井宏雅, 利野靖, 萬哲漢, 湯川寛夫, 和田修幸, 古屋充子, 李進, 中谷行雄, 益田宗孝
    • Journal Title

      日本外科系連合学会誌 34

      Pages: 788-794

    • NAID

      10026096392

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88.2008

    • Author(s)
      Fang H, Mun HS, Kikumura A, Sayama Y, Norose K, Yano A, Aosai F.
    • Journal Title

      Microbiol Immunol 52(7)

      Pages: 366-374

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo study of toxoplasmic parasitemia using interferon-gamma-deficient mice : Absolute cell number of leukocytes, parasite load and cell susceptibility.2008

    • Author(s)
      Norose K, Naoi K, Fang H, Yano A.
    • Journal Title

      Parasitol Int 57(4)

      Pages: 447-453

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The clinical significance of anti-heat shock cognate protein 71 antibody in myasthenia gravis.2008

    • Author(s)
      Munakata S, Chen M, Aosai F, Kawaguchi N, Nemoto Y, Norose K, Hattori T, Yano A.
    • Journal Title

      J Clin Neurosci 15(2)

      Pages: 158-165

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathophysiology of Placentation Abnormalities in Pregnancy-Induced Hypertension.2008

    • Author(s)
      Furuya M, Ishida J, Aoki I, Fukamizu A.
    • Journal Title

      Vasc Health Risk Manag. 4

      Pages: 1301-1313

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer Neovascularization and Proinflammatory Microenvironments.2008

    • Author(s)
      Furuya M,, Yonemitsu Y.
    • Journal Title

      Curr Cancer Drug Target. 8

      Pages: 253-265

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired Placental Neovascularization in Mice with Pregnancy-Associated Hypertension.2008

    • Author(s)
      Furuya M,, Ishida J (equal contribution), Inaba S, Kasuya Y, Kimura S, Nemori R, Fukamizu A.
    • Journal Title

      Lab Invest 88

      Pages: 416-429

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The expression of NeuroD and mASH1 in the gastroenteropancreatic neuroendocrine tumors.2008

    • Author(s)
      Shida T, Furuya M,, Kishimoto T, Nikaido T, Tanizawa T, Koda K, Oda K, Takano S, Kimura F, Shimizu H, Yoshidome H, Ohtsuka M, Nakatani Y, Miyazaki M.
    • Journal Title

      Mod Pathol. 21

      Pages: 1363-1370

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predominance of IgG4+ plasma cells and CD68 positivity in sclerosing angiomatoid nodular transformation (SANT).2008

    • Author(s)
      Nagai Y, Hayama N, Kishimoto T, Furuya M,, Takahashi Y, Otsuka M, Miyazaki M, Nakatani Y.
    • Journal Title

      Histopathology. 53

      Pages: 495-498

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The clinical significance of anti-heat shock cognate protein 71 antibody in myasthenia gravis.2008

    • Author(s)
      Munakata S
    • Journal Title

      J Clin Neurosci 15

      Pages: 158-165

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo study of toxoplasmic parasitemia using interferon-gamma-deficient mice: Absolute cell number of leukocytes, parasite load and cell susceptibility.2008

    • Author(s)
      Norose K
    • Journal Title

      Parasitol Int. 57

      Pages: 447-453

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88.2008

    • Author(s)
      Fang H
    • Journal Title

      Microbiol Immunol 52

      Pages: 366-374

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of skin grafts and organs infected with Toxoglasma gondii as a source of toxoplasmosis in immunocompromised mice.

    • Author(s)
      Belal US, Norose K, Mohamed RM, Naoi K, Yano A.
    • Journal Title

      Jpn. J. Inf. Dis. In press

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective immunity against lethal anaphylactic reaction in Toxoplasma gondirinfected mice by DNA vaccination with T.gondirderived heat shock protein 70 gene

    • Author(s)
      Kikumura A
    • Journal Title

      Parasitology International (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Behavior of T cells in the eye during chronic toxoplasmic retinochoroiditis using two-photonmicroscopy2011

    • Author(s)
      Kazumi Norose, Akitoshi Kikumura, Christopher A.Hunter, Tajie H.Harris.
    • Organizer
      第80回日本寄生虫学会
    • Place of Presentation
      東京東日本大震災のため延期
    • Related Report
      2010 Final Research Report
  • [Presentation] Behavior of T cells in the eye during chronic toxoplasmic retinochoroiditis using two photon microscopy2011

    • Author(s)
      Kazumi Norose
    • Organizer
      第80回日本寄生虫学会
    • Place of Presentation
      東京(震災のため延期)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 超音波検査が虫体先進部の検出に有用であったCreeping diseaseの1例2010

    • Author(s)
      若林正一郎、中野倫代、外川八英、神戸直智、松江弘之、青才文江、野呂瀬一美
    • Organizer
      日本皮膚科学会第834回東京地方会
    • Place of Presentation
      千葉
    • Year and Date
      2010-12-18
    • Related Report
      2010 Final Research Report
  • [Presentation]2010

    • Author(s)
      若林正一郎
    • Organizer
      超音波検査が虫体先進部の検出に有用であったCreeping diseaseの1例-日本皮膚科学会第834回東京地方会
    • Place of Presentation
      千葉
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠高血圧症候群における胎児・胎盤機能評価マーカーの検討2010

    • Author(s)
      古屋充子
    • Organizer
      第391回神奈川県産婦人科医会地方部会
    • Place of Presentation
      平塚
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 腹腔内再発を繰り返した子宮間葉系腫瘍の一例2010

    • Author(s)
      新野史, 窪田興志, 稲山嘉明, 古屋充子
    • Organizer
      第32回日本婦人科病理学会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Distinct expression patterns of CXCR3 variants in tumor and tumor-associated inflammatory diseases of the ovary.2010

    • Author(s)
      古屋充子, 宮城悦子, 平原史樹, 宮城洋平, 稲山嘉明, 太田一郎, 上大介, 長嶋洋治, 青木一郎
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of CXCL10 in ocular toxoplasmosis.2010

    • Author(s)
      Kazumi Norose, Tajie H. Harris, Akitoshi Kikumura, Christopher A. Hunter
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Final Research Report
  • [Presentation] 経過中にCD20陽性を示したangioimmunoblastic T cell lymphomaの一例2010

    • Author(s)
      立花崇孝, 富田直人, 古屋充子, 竹内賢吾, 山中正二, 中村直哉, 藤田浩之, 石ケ坪良明
    • Organizer
      第50回日本リンパ網内系学会
    • Place of Presentation
      新潟
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of CXCL 10 in ocular toxoplasmosis.2010

    • Author(s)
      Kazumi Norose, Tajie H. Harris, Akitoshi Kikumura, Christopher A. Hunter
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Related Report
      2010 Final Research Report
  • [Presentation] 横浜市立大学におけるバイオバンク室の運営と課題2010

    • Author(s)
      稲山嘉明, 山中正二, 村上あゆみ, 中山崇, 大城久, 海野俊徳, 小野響子, 平沙代子, 矢澤卓也, 下山田博明, 奥寺康司, 長嶋洋治, 古屋充子, 長濱清隆, 北村均, 青木一郎
    • Organizer
      第99回日本病理学会春季総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Magnet activated cell sorting (MACS)を用いた糸球体上皮細胞の単離2010

    • Author(s)
      村上あゆみ, 潘勤雅, 大城久, 山中正二, 古屋充子, 長嶋洋治, 青木一郎, 長濱清隆
    • Organizer
      第99回日本病理学会春季総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 卵巣腫瘍におけるINF-γ誘導性ケモカイン受容体CXCR3バリアントの解析2010

    • Author(s)
      古屋充子, 米山朋那, 宮城悦子, 田中玲子, 上大介, 長濱清隆, 長嶋洋治, 宮城洋平, 稲山嘉明, 青木一郎
    • Organizer
      第99回日本病理学会春季総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] Birt-Hogg-Dube症候群と判明した多発性肺嚢胞の病理学的特徴2010

    • Author(s)
      古屋充子, 古賀俊輔, 高橋葉子, 田中玲子, 廣島健三, 岡本龍郎, 吉野一郎, 青木一郎, 中谷行雄
    • Organizer
      第99回日本病理学会春季総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of CXCL10 in ocular toxoplasmosis.2010

    • Author(s)
      Kazumi Norose
    • Organizer
      14^<th>International Congress of lmmuno10gy
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of CXCL10 in ocular toxoplasmosis.2010

    • Author(s)
      Kazumi Norose
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠高血圧症候群における胎盤解析の展望2009

    • Author(s)
      古屋充子
    • Organizer
      第389回神奈川県産婦人科医会地方部会
    • Place of Presentation
      相模大野
    • Year and Date
      2009-11-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠高血圧症候群における胎盤血管新生の病態解析2009

    • Author(s)
      古屋充子, 石田純治, 武内利直, 碓井宏和, 深水昭吉
    • Organizer
      第388回神奈川県産婦人科医会地方部会
    • Place of Presentation
      横浜
    • Year and Date
      2009-07-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮頚部絨毛腺管状乳頭腺癌villoglandular papillary adenocarcinomaの一例2009

    • Author(s)
      井畑穣, 宮城悦子, 下山田博明, 小林友紀, 杉浦賢, 古屋充子, 北村和久, 山中正二、稲山嘉明, 平原史樹
    • Organizer
      第48回日本臨床細胞学会秋期大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 卵管癌と子宮頸部腺癌の共存により細胞診断に苦慮した1例2009

    • Author(s)
      杉浦賢, 宮城悦子, 助川明子, 古屋充子, 北村和久, 稲山嘉明, 平原史樹
    • Organizer
      第48回日本臨床細胞学会秋期大会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 当院における絨毛性疾患10年の検討2009

    • Author(s)
      井畑穰, 鈴木理絵, 助川明子, 杉浦賢, 宮城悦子, 古屋充子, 山中正二, 平原史樹
    • Organizer
      第47回日本癌治療学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 脳生検にて確定診断に至った、Immunocompetent host発症トキソプラズマ脳炎の1例2009

    • Author(s)
      大封昌子、三枝隆博、小林勝哉、渡邉究、中谷嘉文、野呂瀬一美、青才文江、宮崎之男
    • Organizer
      第14回日本神経感染症学会総会
    • Place of Presentation
      宇都宮
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Expression of CXCR3 variant in ovarian neoplasms.2009

    • Author(s)
      Furuya M, Miyagi E, Hirahara F, Miyagi Y, Inayama Y, Ota I, Kami D, Nagashima Y, Aoki I
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Pathophysiology of the lung cysts caused by BHD mutation in Birt-Hogg-Dube syndrome patients.2009

    • Author(s)
      古賀俊輔, 古屋充子, 吉野一郎, 廣島健三, 青木一郎, 中谷嘉文
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠高血圧症候群における胎盤血管新生の病態解析2009

    • Author(s)
      古屋充子, 石田純治, 武内利直, 碓井宏和, 生水真紀夫, 中谷行雄, 上大介, 梅澤明弘, 青木一郎, 深水昭吉
    • Organizer
      第30回日本妊娠高血圧学会総会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠高血圧症モデルマウスにおける胎盤の血管構造変化に関する研究2009

    • Author(s)
      石田純治, 古屋充子, 稲葉早紀, 粕谷善俊, 木村定雄, 根守良一, 深水昭吉
    • Organizer
      第30回日本妊娠高血圧学会総会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] 子宮体部原発扁平上皮癌の一例2009

    • Author(s)
      長谷川哲哉, 宮城悦子, 佐治日青哉, 井畑穣, 鈴木理絵, 助川明子, 平原史樹, 古屋充子, 北村和久, 稲山嘉明
    • Organizer
      第50回日本臨床細胞学会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] WT1遺伝子のexon10のナンセンス変異を認め腎移植に至った1例2009

    • Author(s)
      村上あゆみ, 長濱清隆, 原田知典, 伊藤秀一, 寺西純一, 江中牧子, 田辺美樹子, 河内香江, 佐々木毅, 野澤昭典, 古屋充子, 長嶋洋治, 青木一郎
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 卵巣腫瘍における血管作動性ケモカイン受容体CXCR3とそのリガンドの発現解析2009

    • Author(s)
      米山朋那, 古屋充子, 宮城悦子, 平原史樹, 宮城洋平, 太田一郎, 西川朱實, 長嶋洋治, 青木一郎
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] BHD遺伝子異常に基づく多発性肺嚢胞・嚢胞発症機構に関する分子病理学的考察2009

    • Author(s)
      古賀俊輔, 古屋充子, 高橋葉子, 山口淳, 田中玲子, 安福和弘、吉野一郎, 廣島健三, 青木一郎, 中谷行雄
    • Organizer
      第98回日本病理学会総会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] A Case of Multiple Pulmonary Cysts Associated with Birt-Hogg-Dube Gene Mutation.2008

    • Author(s)
      Koga S, Furuya M, Takahashi Y, Tanaka R, Yasufuku K, Yamaguchi A, Yoshino I, Kumasaka T, Nakatan Y
    • Organizer
      1st INAUGURAL BHD SYMPOSIUM
    • Place of Presentation
      Roskilde
    • Year and Date
      2008-09-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Protective immunity against Toxoplasma gondii heat shoek protein 70-indueed anaphylactic reaction by DNA vaccination.2008

    • Author(s)
      Akitoshi Kikumura, Hao Fang, Yusuke Sayama, Masayuki Makino, Noriko Uemura, Kazumi Norose, Akihiko Yano, Fumie Aosai
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Implication of CXC-chemokines and their receptors for proinflammatory microenvironments of ovarian neoplasms.2008

    • Author(s)
      Furuya M, Suyama T, Usui H, Tanaka N, Shozu M, Miyagi E, Hirahara F, Nagashima Y, Aoki I
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] The expression of Neuro D and mash in the gastroenteropancreatic neuroendocrine tumors.2008

    • Author(s)
      Shida T, Furuya M, Kishimoto M, Takano S, Miyazaki M
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Final Research Report
  • [Presentation] 妊娠高血圧症候群における血管新生の病態解析2008

    • Author(s)
      古屋充子, 石田純治, 武内利直, 碓井宏和, 中谷行雄, 深水昭吉
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] Birt-Hogg-Dube syndromeが疑われる肺嚢胞性疾患の分子病理学的検討2008

    • Author(s)
      古賀俊輔, 古屋充子, 高橋葉子, 田中玲子, 安福和弘, 吉野一郎, 熊坂利夫, 岸本充, 谷澤徹, 廣島健三, 中谷行雄
    • Organizer
      第97回日本病理学会総会
    • Place of Presentation
      金沢
    • Related Report
      2010 Final Research Report
  • [Presentation] IL-10siRNAによるトキソプラズマ由来HSP70による骨髄由来樹状細胞の成熟とIL-12産生の増強効果2008

    • Author(s)
      佐山勇輔、菊村亮暁、房浩、牧野真幸、野呂瀬一美、矢野明彦、青才文江
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] トキソプラズマ感染マウスのトキソプラズマHSP70誘導アナフィラキシー反応におけるTLR4/MyD88依存性cPLA2/PAF活性化2008

    • Author(s)
      房浩、文恵聖、菊村亮暁、佐山勇輔、牧野真幸、野呂瀬一美、矢野明彦、青才文江
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] トキソプラズマ感染マウスのトキソプラズマHSP70誘導アナフィラキシー死に対するワクチン開発2008

    • Author(s)
      菊村亮暁、房浩、佐山勇輔、文恵聖、牧野真幸、野呂瀬一美、矢野明彦、青才文江
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report
  • [Presentation] トキソプラズマ感染マウスのトキソプラズマHSP70誘導アナフィラキシー死に対するワクチン開発。2008

    • Author(s)
      菊村亮暁
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] IL-10siRNAによるトキソプラズマ由来HSP70による骨髄由来樹状細胞の成熟とIL-12産生の増強効果。2008

    • Author(s)
      佐山勇輔
    • Organizer
      第77回日本寄生虫学会大会
    • Place of Presentation
      長崎
    • Related Report
      2008 Annual Research Report
  • [Presentation] Protective immunity against Toxoplasma gondii heat shock protein 70-induced anaphylactic reaction by DNA vaccination.2008

    • Author(s)
      Kikumura Akitoshi
    • Organizer
      第38回日本免疫学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.m.chiba-u.ac.jp/class/infection-hostdefense/

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/infection-hostdefense/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/infection-hostdefense/gyouseki.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/infection-hostdefense/gyouseki.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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