| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
We established the model of congenital toxoplasmic retinochoroiditis. The expression of IFN-γ, chemokines and adherence molecules in the retina were extremely high after infection. Thus, IFN-γ, chemokines and adherence molecules have important roles on the mechanisms of pathogenesis of congenital toxoplasmic retinochoroiditis. Toxoplasma gondii was detected in the retina and there were cell infiltration around the retinal vessels showing vasculitis and leakage of fluorescence dye in the retina.
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