Analysis for mechanisms of immune suppression by human corneal endothelial cells
| Project/Area Number |
20592073
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
SUGITA Sunao Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 講師 (10299456)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Manabu 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10010464)
SUGAMOTO Yoshiharu 東京医科歯科大学, 医学部附属病院, 講師 (20334419)
KAMOI Koju 東京医科歯科大学, 医学部附属病院, 助教 (40451942)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 角膜内皮細胞 / T細胞 / 免疫寛容 / 角膜 / 眼組織 / 抑制 / 炎症 / 角膜内皮 / 培養細胞 |
|---|
| Research Abstract |
Corneal endothelial cells have immunosuppressive activities. We report here that human corneal endothelial cell lines significantly suppressed activation of CD4^+ T cells, CD8^+ T cells, pan-T cells in vitro. Moreover, cultured corneal endothelial cell lines converted CD8^+ T cells into Treg cells that have immunosuppressive capacity. The CE-induced Treg cells greatly expressed CD25high and Foxp3. Therefore, we demonstrated that human corneal endothelial cells indicate suppression of bystander T cell activation and induction of regulatory T cells in vitro.
|
Report
(4 results)
Research Products
(14 results)
-
-
-
-
-
-
[Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1 (PD-L1) suppress PD-1^+ T helper 1 cells by a contact-dependent mechanism.2009
Author(s)
Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S.
-
Journal Title
Invest.Ophthalmol.Vis.Sci. 50
Pages: 263-272
Related Report
-
[Journal Article] Human corneal endothelial cells expressing programmed death-ligand 1(PD-L1)suppress PD-1^+ T helper 1 cells by a contact-dependent mechanism.2009
Author(s)
Sugita S, Usui Y, Horie S, Futagami Y, Yamada Y, Ma J, Kezuka T, Hamada H, Usui T, Mochizuki M, Yamagami S.
-
Journal Title
Invest.Ophthalmol.Vis.Sci. 50
Pages: 263-272
Related Report
Peer Reviewed
-
-
-
-
-
-
-
