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Generation of nitric oxide synthase transgenic mice and analysis of their visual function

Research Project

Project/Area Number 20592074
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNagoya University

Principal Investigator

KOMEIMA Keiichi  Nagoya University, 大学院・医学系研究科, 助教 (40362256)

Co-Investigator(Kenkyū-buntansha) KONDO Mineo  名古屋大学, 大学院・医学系研究科, 准教授 (80303642)
TERASAKI Hiroko  名古屋大学, 大学院・医学系研究科, 教授 (40207478)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords一酸化窒素(NO) / 誘導型一酸化窒素合成酵素(iNOS) / 網膜色素上皮細胞 / トランスジェニックマウス / 酸化・ニトロ化ストレス / VMD2プロモーター / 加齢黄斑変性 / 網膜色素変性症
Research Abstract

We generated 5 lines of inducible nitric oxide synthase transgenic mice. Fundus examination revealed retinal drusen in 3 lines of transgenic mice. These results indicated that nitric oxide overexpressed in the outer layer of retinas caused oxidative stress and degenerative change in mouse retinas as is seen in the patients of age-related macular degeneration.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (7 results)

  • [Journal Article] Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.2010

    • Author(s)
      Nishiguchi KM, Kataoka K, Kachi S, Komeima K, Terasaki H.
    • Journal Title

      PLoS One. 55

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inner Retinal Cleavage Associated With Idiopathic Epiretinal Membrane.2010

    • Author(s)
      Komeima, K, Ito Y, Nakamura, M, Terasaki H.
    • Journal Title

      Retin Cases Brief Rep. 4

      Pages: 132-134

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate.2010

    • Author(s)
      Nishiguchi KM, Kataoka K, Kachi S, Komeima K, Terasaki H.
    • Journal Title

      PLoS One.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inner Retinal Cleavage Associated With Idiopathic Epiretinal Membrane2010

    • Author(s)
      Komeima. K, Ito Y, Nakamura, M, Terasaki H.
    • Journal Title

      Retin Cases Brief Rep.

      Volume: 4 Pages: 132-134

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supernormal ERG oscillatory potentials in transgenic rabbit with rhodopsin P347L mutation and retinal degeneration.2009

    • Author(s)
      Sakai T, Kondo M, Ueno S, Koyasu T, Komeima K, Terasaki H.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 4402-4409

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of catalase and superoxide dismutase 2 reduces cone cell death in retinitis pigmentosa.2009

    • Author(s)
      Usui S, Komeima K, Lee SY, Jo YJ, Ueno S, Rogers BS, Wu Z, Shen J, Lu L, Oveson BC, Rabinovitch PS, Campochiaro PA.
    • Journal Title

      Mol Ther. 17

      Pages: 778-786

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage.2009

    • Author(s)
      Lu L, Oveson BC, Jo YJ, Lauer TW, Usui S, Komeima K, Xie B, Campochiaro PA.
    • Journal Title

      Antioxid Redox Signal. 11

      Pages: 715-724

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Supernormal ERG oscillatory potentials in transgenic rabbit with rhodo psin P347L mutation and retinal degeneration.2009

    • Author(s)
      Sakai T, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 4402-9

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of glutathione peroxidase 4 strongly protects retina from oxidative damage.2009

    • Author(s)
      Lu L, et al.
    • Journal Title

      Antioxid Redox Signal. 11

      Pages: 715-24

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased expression of catalase and superoxide dismutase 2 reduces co ne cell death in retinitis pigmentosa.2009

    • Author(s)
      Usui S, et al.
    • Journal Title

      Mol Ther. 17

      Pages: 778-86

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 一酸化窒素と網膜疾患2009

    • Author(s)
      米今敬一
    • Journal Title

      臨床眼科 63

      Pages: 9-14

    • NAID

      40016440950

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Generation of a Transgenic Rabbit Model of Retinal Degeneration.2009

    • Author(s)
      Kondo M, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci. 50

      Pages: 1371-1377

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Expression of Glutathione Peroxidase 4 Strongly Protects Retina from Oxidative Damage.2008

    • Author(s)
      Lu L, et al.
    • Journal Title

      Antioxid Redox Signal. (In Press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pismentosa.2008

    • Author(s)
      Komeima K, et al.
    • Journal Title

      Free Radic Biol Med. 45

      Pages: 905-912

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Girdin phosphorylation at serine-1416 by Akt/PkB promotes postneonatal angiogenesis and ischemic neovascularization in the retina.2010

    • Author(s)
      Takanori Ito, Keiichi Komeima, Tetsuhiro Yasuma, et al.
    • Organizer
      ARVO Meeting
    • Place of Presentation
      Ft.Lauderdale, USA
    • Year and Date
      2010-05-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Girdin phosphorylation at serine-1416 by Akt/PkB promotes postneonatal angiogenesis and ischemic neovascularization in the retina2010

    • Author(s)
      Takanori Ito, Keiichi Komeima, Tetsuhiro Yasuma, et al.
    • Organizer
      ARVO Meeting 2010
    • Place of Presentation
      Ft.Lauderdale, USA
    • Year and Date
      2010-05-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] The functional role of Akt substrate Girdin in retinal angiogenesis2010

    • Author(s)
      Keiichi Komeima
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] The functional role of Akt substrate Girdin in retinal angiogenesis2010

    • Author(s)
      米今敬一
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 網膜静脈閉塞の病態生理に対する考察2009

    • Author(s)
      米今敬一
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 網膜静脈閉塞の病態生理に対する考察2009

    • Author(s)
      米今敬一
    • Organizer
      第63回 日本臨床眼科学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 網膜色素変性症と一酸化窒素2008

    • Author(s)
      米今敬一
    • Organizer
      第47回日本網膜硝子体学会総会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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