| Project/Area Number |
20592075
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
KONDO Mineo Nagoya University, 大学院・医学系研究科, 准教授 (80303642)
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| Co-Investigator(Kenkyū-buntansha) |
TERASAKI Hiroko 名古屋大学, 大学院・医学系研究科, 教授 (40207478)
ITO Yasuki 名古屋大学, 大学院・医学系研究科, 特任准教授 (10313991)
KACHI Shu 名古屋大学, 医学部附属病院, 講師 (30345904)
KOMEIMA Keiichi 名古屋大学, 大学院・医学系研究科, 助教 (40362256)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 網膜色素変性 / 動物モデル / ウサギ / 網膜電図 / トランスジェニック / 網膜変性 / ロドプシン / 視細胞 |
|---|
| Research Abstract |
We have generated a rabbit model of retinitis pigmentosa (RP), the rhodopsin P347L transgenic (Tg) rabbit, by using bacterial artificial chromosome (BAC) transgenesis. These rabbits showed a rod-dominant, progressive retinal degeneration with a marked regional variations in the loss of photoreceptors. All of the electroretinogram components of the Tg rabbits decrease progressively with the a-wave more affected than the b-wave, and the oscillatory potentials (OPs) were the best preserved. Interestingly, the OP amplitudes of young Tg rabbits were significantly larger than those of wild-type rabbits. Pharmacological experiments showed that the significantly larger OPs in young Tg rabbits resulted from secondary alterations in the inner retinal function.
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