| Project/Area Number |
20592076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Dai 鳥取大学, 医学部附属病院, 講師 (30346358)
IKEDA Yoshifumi 鳥取大学, 医学部, 助教 (10444639)
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| Research Collaborator |
TERASAKA Yuki 鳥取大学, 大学院・医学系研究科, 大学院生
TAKEDA Sachiko 鳥取大学, 大学院・医学系研究科, 大学院生
HARUKI Tomoko 鳥取大学, 大学院・医学系研究科, 大学院生
SASAKI Shin-ichi 鳥取大学, 大学院・医学系研究科, 大学院生
YAKURA Keiko 鳥取大学, 医学部・医学科, 技術補佐員
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 眼微生物学 / 感染症学 / 単純ヘルペスウイルス / 角膜ヘルペス / 角膜内皮 / IDO / toll-like receptor9(TLR9) / 調節性リンパ球(Treg) / IL-10 / 混合リンパ球刺激試験 / マイクロアレイ / 角膜上皮 / IL-6 / VEFG / helicasee-primase / TLR-9 / プロテインアレイ / 抗原呈示 / helicase-primase阻害 / T細胞 / MAPkinase / TLR / MAP kinase / VEGF |
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| Research Abstract |
To elucidate the pathogenesis of herpetic keratitis, microarray analyses were preformed using HSV-1-infected immortalized corneal epithelial and endothelial cells. Among various molecules related with HSV infection, the roles of IL-6 and VEGF in the epithelial cells and toll-like receptor 9(TLR9) and indoleamine 2, 3-dioxygenase 1(IDO1) in the endothelial cells were analyzed. Especially it was found that corneal endothelial cells can induce HSV-1-speficic regulatory T cells via these molecules.
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