| Project/Area Number |
20592079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Ehime University |
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Principal Investigator |
SHIRAISHI Atsushi Ehime University, 大学院・医学系研究科, 寄附講座准教授 (90314963)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Takeshi 愛媛大学, 大学院・医学系研究科, 寄附講座助教 (70380285)
|
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| Co-Investigator(Renkei-kenkyūsha) |
OHASHI Yuichi 愛媛大学, 大学院・医学系研究科, 教授 (00116005)
SHIRAKATA Yuji 愛媛大学, 大学院・医学系研究科, 講師 (50226320)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 眼発生 / 再生医学 / 角膜上皮 / 再生医療 / マウス表皮細胞 / 形質転換 / マウス角膜上皮細胞 / ケラチン12 / マウス角膜 / 培養 |
|---|
| Research Abstract |
In the present study, we investigated the potential for murine epidermal cells transdifferentiation into corneal epithelial-like cells, and demonstrate that murine epidermal cells have the potential to transdifferentiate into corneal epithelial-like cells. The results indicate that transdifferentiation may require the effect of coculture with corneal epithelial cells, as well as the corneal limbal environment.
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