The inhibition of subretinal fibrosis due to choroidal neovascularization
Project/Area Number |
20592080
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Kyushu University |
Principal Investigator |
SONODA Kohei Kyushu University, 大学院・医学系研究科, 教授 (10294943)
|
Co-Investigator(Kenkyū-buntansha) |
HATA Yasuaki 福岡歯科大学, 眼科, 教授 (90346776)
ISHIBASHI Tatsuro 九州大学, 大学院・医学研究院, 教授 (30150428)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 自然免疫 / 脈絡膜血管新生 / 網膜瘢痕 / 遺伝子治療 |
Research Abstract |
Activated macrophages formed subretinal fibrosis when they were placed in the subretinal space and induce myofibrotic changes in RPE cells. The major factors to form fibrosis were IL-6 and MCP-1. We confirmed the in vivo blocking of IL-6 and MCP-1 reduced subretinal fibrosis and might be beneficial to maintain visual acuity in CNV-related diseases.
|
Report
(4 results)
Research Products
(5 results)