The inhibition of subretinal fibrosis due to choroidal neovascularization

Research Project

Project/Area Number	20592080
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Ophthalmology
Research Institution	Kyushu University
Principal Investigator	SONODA Kohei Kyushu University, 大学院・医学系研究科, 教授 (10294943)
Co-Investigator(Kenkyū-buntansha)	HATA Yasuaki 福岡歯科大学, 眼科, 教授 (90346776) ISHIBASHI Tatsuro 九州大学, 大学院・医学研究院, 教授 (30150428)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	自然免疫 / 脈絡膜血管新生 / 網膜瘢痕 / 遺伝子治療
Research Abstract	Activated macrophages formed subretinal fibrosis when they were placed in the subretinal space and induce myofibrotic changes in RPE cells. The major factors to form fibrosis were IL-6 and MCP-1. We confirmed the in vivo blocking of IL-6 and MCP-1 reduced subretinal fibrosis and might be beneficial to maintain visual acuity in CNV-related diseases.

Report

(4 results)