| Project/Area Number |
20592084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Masahiko 近畿大学, 医学部, 准教授 (40218938)
ABE Kousuke 近畿大学, 医学部, 講師 (00222646)
HIGAKI Shiro 近畿大学, 医学部附属病院, 准教授 (90238262)
SUGAHARA Daisuke 近畿大学, 医学部, 講師 (30309314)
SUGIOKA Kouji 近畿大学, 医学部, 講師 (50399119)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ウイルス / 感染症 / 細胞 / 組織 / 角膜ヘルペス / PCR / DNA / 細胞・組織 / 潜伏感染 / 再活性化 / ヘルペス / HSV / 角膜 / 角膜移植 |
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| Research Abstract |
We detected herpes simplex virus types 1 (HSV-1) and 2 (HSV-2), varicella zoster virus (VZV), and cytomegalovirus (CMV) DNAs in recipient corneal buttons taken at the time of penetrating keratoplasty. HSV-1, HSV-2, VZV, and CMV DNAs were detected in 10, 1, 9, and 2 of the 27 recipient corneal buttons, respectively.
The rates of HSV DNA positivity were 1/12 (8.3%), 3/11 (27.3%), and 4/15 (26.7%) in normal eye, dry eye, and conjunctivitis, respectively.
Seven medications were investigated for their efficacy in suppressing HSV-1 reactivation in mouse model. Bromfenac Na eye drop, intramuscular AMP, and intraperitoneal geldanamycin suppressed the HSV-1 reactivation.
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