| Project/Area Number |
20592090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIOKAWA Yuichi Kyushu University, 大学病院, 講師 (70457422)
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| Co-Investigator(Kenkyū-buntansha) |
富永 隆治 (冨永 隆治) 九州大学, 医学研究院, 教授 (70136464)
田ノ上 禎久 九州大学, 大学病院, 助教 (40372742)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児体外循環 / 小型遠心ポンプ / 左心補助 |
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| Research Abstract |
We have developed an ultraminiature centrifugal pump, TinyPunip, with a priming volume of 5 ml. The in vivo performance of Tiny Pump was compared with that of HPM-05 for left ventricular support. Each pump group included 7 rabbits weighing 3.4-3.8kg. One rabbit in the TinyPump group and two rabbits in the HPM-05 goup died of unsuccessful cannulation. The remaining rabbits (6 in the TinyPump group and 5 in the HPM-05 group) were instrumented and observed for 240 min. The pump flow was maintained at around 200 ml/min. The priming volumes of the entire circuits were 25 and 45ml for TinvPump and HPM-05, respectly. TinyPump required a higher rotation speed (2214±47 vs.1261±87 rpm, p<0.05)because of its Km all priming Volume, but showed a similar plasma free hemoglobin level to HPM-05. The hematocrit values were kept higher in the TinyPump group during ventricular support (24.3±1.4% vs. 20.1±1.4% at 240 min, p<0.05),The mean arterial pressure did not differ between the two groups. The biochemical parameters were also equivalent in the two groups. Overall, TinyPump exhibited a feasible in vivo performance. This ultraminiature device would offer promising outcomes for neonates and infants with intractable heart failure.
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