| Project/Area Number |
20592091
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Keio University |
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Principal Investigator |
SHIMOJIMA Naoki Keio University, 医学部, 講師 (30317151)
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| Co-Investigator(Kenkyū-buntansha) |
MORIKAWA Yasuhide 慶應義塾大学, 医学部, 教授 (90124958)
OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
SHIBATA Shinsuke 慶應義塾大学, 医学部, 助教 (70407089)
NAGOSHI Narihito 慶應義塾大学, 医学部, (助教) (10383837)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 先天性消化器疾患学 / ヒルシュスプルング病 / 小児外科 / 再生医療 / 神経堤 / 幹細胞移植 / 再生医学 |
|---|
| Research Abstract |
Hirschsprung's disease and allied diseases are congenital loss or abnormal development of enteric nervous system. We investigated a feasibility of neural crest stem cell transplantation as a novel therapy alternative to surgery. Neural crest stem cells are co-cultured with gut from Hirschsprung's disease model. Survival, migration, and differentiation of transplanted cells were investigated.
To clarify etiologies of these disease, genomic DNA is extracted and mutation analyses were carried out.
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