Optimal timing of fetal therapy for lower urinary tract obstruction in fetal lambs.
| Project/Area Number |
20592093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
KITAGAWA Hiroaki St.Marianna University School of Medicine, 医学部, 教授 (80153097)
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| Co-Investigator(Kenkyū-buntansha) |
SEKI Yasuji 聖マリアンナ医科大学, 医学部, 非常勤講師 (20309462)
KOIKE Junki 聖マリアンナ医科大学, 医学部, 准教授 (40308440)
WAKISAKA Munechika 聖マリアンナ医科大学, 医学部, 准教授 (30267596)
NAGAE Hideki 聖マリアンナ医科大学, 医学部, 助教
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 胎児手術学 / 胎児治療 / 多嚢腎 / 後部尿道弁 / 胎児尿路閉塞 / 胎児水腎症 / 急性尿細管壊死 / 胎児手術 / 尿路閉塞 |
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| Research Abstract |
Introduction : Lower urinary tract obstruction causes renal failure bladder dysfunction after birth. We examined the morphological changes of the early obstructive kidney and bladder to determine the optimal timing for fetal therapy.
Materials and Methods : We created obstructive uropathy in fetal lambs at 60 days' gestation by ligating the urethra and urachus. The fetuses were delivered at 2, 3, 4, 5, 7, 14 days after obstruction and at term (145 days gestation). We focused on the early structure of the kidney and bladder wall thickness & structure, comparing obstructive and control lambs.
Results : Dilation of Bowman's capsule and the proximal tubules started from day two. Acute tubular necrosis (ATN) was also observed up to day 7. Numerous cysts were present throughout the kidney at term. The bladder wall was initially expanded and stretched out but by the 4th day the bladder wall became thicker.
Conclusion : Shunting operations to preserve bladder function may be needed earlier than we had expected.
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Report
(4 results)
Research Products
(31 results)
