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TPN administration lead to alteration of hepatocyte cell cycle and metabolic abnormalities in the mouse model with intestinal failure

Research Project

Project/Area Number 20592094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionOsaka University

Principal Investigator

TAZUKE Yuko  Osaka University, 医学部, 講師 (10397698)

Co-Investigator(Kenkyū-buntansha) KOSAKU Maeda  自治医科大学, 医学部, 教授 (60332756)
FUKUZAWA Masahiro  大阪大学, 医学部, 教授 (60165272)
OKUYAMA Hiroomi  兵庫医科大学, 医学部, 教授 (30252670)
FUJIMOTO Jiro  兵庫医科大学, 医学部, 教授 (90199373)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腸管機能障害 / 中心静脈栄養 / 肝機能障害 / 細胞周期 / 肝細胞
Research Abstract

The aim of this study was to test the hypothesis that PN administration in the mouse models with intestinal failure would lead to alteration of hepatocyte cell cycle and metabolic abnormalities of glucose and lipids and subsequently lead to an altered abundance of adipocytokines and their related gene expression in a rat model. This study also investigated whether some or all of these PN-associated metabolic abnormalities are related to parenteral lipid administration. The study shows that PN led to specific alterations in the abundance of adipocytokines and PPARs. These changes give critical insight into many of the metabolic derangements in lipid metabolism, which patients may experience with PN.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results) Remarks (1 results)

  • [Journal Article] Protective mechanism of glutamine on the expression of proliferating cell nuclear antigen after cisplatin-induced intestinal mucosal injury2011

    • Author(s)
      Yuko Tazuke, Kosaku Maeda, Masafumi Wasa, Nose Satoko, Masahiro Fukuzawa
    • Journal Title

      Pediatric surgery international 27巻

      Pages: 151-158

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tpn Administration Leads to Specific Alterations in the Expression of Adipocytokines and Ppars in a rat Model JPEN2011

    • Author(s)
      Yuko Tazuke, Daniel Teitelbaum, Masafumi Wasa, Masahiro Fukuzawa, Yasuhiko Iiboshi, Jiro Fujimoto
    • Journal Title

      Journal of Parenteral and Enteral Nutrition 35巻

      Pages: 329-336

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective mechanism of glutamine on the expression of proliferating cell nuclear antigen after cisplatin-induced intestinal mucosal injury2011

    • Author(s)
      Yuko Tazuke
    • Journal Title

      Pediatric surgery international

      Volume: 27 Pages: 151-158

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tpn Administration Leads to Specific Alterations in the Expression of Adipocytokines and Ppars in a rat Model2011

    • Author(s)
      Yuko Tazuke
    • Journal Title

      JPEN : Journal of Parenteral and Enteral Nutrition

      Volume: 35 Pages: 329-336

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Protective Mechanism of Glutamine on the Expression of Proliferating Cell Nuclear Antigen (PCNA) after Cisplatin Induced Intestinal Mucosal Injury2010

    • Author(s)
      Yuko Tazuke
    • Organizer
      The XXIII International Symposium of Paediatric Surgical Research
    • Place of Presentation
      Tokyo
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] The Protective Mechanism of Glutamine on the Expression of Proliferating Cell Nuclear Antigen(PCNA)after Cisplatin Induced Intestinal Mucosal Injury2010

    • Author(s)
      Yuko Tazuke, Kosaku Maeda, et al.
    • Organizer
      The XXIII International Symposium of Paediatric Surgical Research
    • Place of Presentation
      Tokyo
    • Related Report
      2010 Final Research Report
  • [Presentation] 中心静脈栄養に関連したアディポサイトカイン発現の変化2009

    • Author(s)
      田附裕子, 和佐勝史, 福澤正洋, 飯干泰彦, 藤元治朗, Teitelbaum Daniel
    • Organizer
      日本外科代謝栄養学会(46)
    • Place of Presentation
      文京区
    • Related Report
      2010 Final Research Report
  • [Presentation] 長期TPN症例におけるL-カルニチン投与の必要性について-短腸症候群症例の治療経験より2009

    • Author(s)
      田附裕子, 澤井利夫, 曹英樹, 和佐勝史, 福澤正洋
    • Organizer
      日本小児外科学会(46)
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 中心静脈栄養に関連したアディポサイトカイン発現の変化2009

    • Author(s)
      田附裕子
    • Organizer
      第46回 日本外科代謝栄養学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] TPN administration lead to specific alterations in adipocytokines and Ppars expressions in a rat model.2008

    • Author(s)
      Yuko Tazuke, Daniel H Teitelbaum, Kazuko Aizawa, Keiko Mitani, Yasuhiko Iiboshi, Masafumi Wasa, Jiro Fujimoto
    • Organizer
      ASPEN 2008
    • Place of Presentation
      Chicago, USA,
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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