Implication of the endoplasmic reticulum stress response in postischemic alopecia and tolerance for ischemic stress of hair follicles.
| Project/Area Number |
20592095
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
IMAI Yoshimichi Tohoku University, 大学院・医学系・研究科, 講師 (80323012)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEDA Atushi 東北大学, 病院, 助教 (30333800)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 皮弁 / 虚血ストレス / 小胞体ストレス / Heat Shock Protein(HSP) / GRP78 / 脱毛 / xbp-1 / 虚血 / 毛周期 / apoptosis |
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| Research Abstract |
The purpose of this study is to reveal the mechanism of alopecia after transient ischemia in the skin flaps. Under ischemic stress with skin flaps, the tolerance for ischemic stress was difference between anagen follicles which got into subcutaneous tissue and telogen follicles which staid in dermis tissue. This made it clear that transient ischemic stress with anagen follicles caused alopecia selectively. And this study suggest that one of a factor made these differences of tolerance with anagen and telogen follicles was the endoplasmic reticulum stress response.
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Report
(4 results)
Research Products
(6 results)
