Implication of the endoplasmic reticulum stress response in postischemic alopecia and tolerance for ischemic stress of hair follicles.

• Project/Area Number: 20592095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Tohoku University
• Principal Investigator: IMAI Yoshimichi Tohoku University, 大学院・医学系・研究科, 講師 (80323012)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Atushi 東北大学, 病院, 助教 (30333800)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 皮弁 / 虚血ストレス / 小胞体ストレス / Heat Shock Protein(HSP) / GRP78 / 脱毛 / xbp-1 / 虚血 / 毛周期 / apoptosis

Research Abstract

The purpose of this study is to reveal the mechanism of alopecia after transient ischemia in the skin flaps. Under ischemic stress with skin flaps, the tolerance for ischemic stress was difference between anagen follicles which got into subcutaneous tissue and telogen follicles which staid in dermis tissue. This made it clear that transient ischemic stress with anagen follicles caused alopecia selectively. And this study suggest that one of a factor made these differences of tolerance with anagen and telogen follicles was the endoplasmic reticulum stress response.

Research Products

• [Presentation] 毛周期による毛包の対虚血耐性の相違と小胞体ストレスの関与 (2010)
  • Author(s): 渡辺悠子
  • Organizer: 第18回日本形成外科学会基礎学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-02
• [Presentation] 周期別毛包の虚血耐性と小胞体ストレス反応の関与 (2010)
  • Author(s): 渡辺悠子
  • Organizer: 第19回日本形成外科学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-16
• [Presentation] 周期別毛包の虚血耐性と小胞体ストレス反応の関与 (2010)
  • Author(s): 渡辺悠子
  • Organizer: 第19回 日本形成外科学会基礎学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-16
• [Presentation] 毛包の対虚血耐性に関する研究 (2010)
  • Author(s): 渡辺悠子
  • Organizer: 第19回東北大学形成外科同門会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-02-21
• [Presentation] 毛周期による毛包の虚血耐性の相違と小胞体ストレス反応の関与 (2009)
  • Author(s): 渡辺悠子
  • Organizer: 第18回 日本形成外科学会基礎学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-02
• [Remarks] ホームページ等