The effects of tissue perfusion for wound biofilm

• Project/Area Number: 20592096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Plastic surgery
• Research Institution: Tohoku University
• Principal Investigator: ATSUSHI Takeda Tohoku University, 病院, 助教 (30333800)
• Co-Investigator(Kenkyū-buntansha): MASAHIRO Tachi 東北大学, 大学院・医学系研究科, 教授 (50312004) ; 鳥谷部 荘八 東北大学, 病院, 助教 (90375006)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 創傷治癒 / 感染 / バイオフィルム / TNF-α / 皮膚難治性潰瘍 / 虚血 / 創傷被覆剤

Research Abstract

Inoculation with Pseudomonas aeruginosa had accelerated re-epithelialization in rats wounds. Flow cytometry detected higher levels of TNF-a in the infiltrating neutrophils. Quorum sensing mutant induced delayed wound healing.

Research Products

• [Journal Article] Wound healing in skin promoted by inoculation with Pseudomonas aeruginosa PAO1 : the critical role of TNF-・secreted from infiltrating neutrophils. (2011)
  • Author(s): Emi Kannol, Kazuyoshi Kawakami, Masae Ritsu, Keiko Ishii, Hiromasa Tanno, Sohachi Toriyabe, Yoshimichi Imai, Ryoko Maruyamal, Masahiro Tachi
  • Journal Title: Wound Repair and Regeneration (in press)
  • Peer Reviewed
• [Journal Article] Biofilm formation on rat skin wounds by Pseudomonas aeruginosa carrying the green fluorescent protein gene. (2010)
  • Author(s): Kanno E, Toriyabe S, Zhang L, Imai Y, Tachi M
  • Journal Title: Exp Dermatol. 19(2) Pages: 154-6
  • Peer Reviewed
• [Journal Article] 慢性創傷における細菌感染の考え方 (2010)
  • Author(s): 館正弘
  • Journal Title: 日本下肢救済・足病学会誌 Volume: 2 Pages: 87-92
• [Journal Article] 創傷治癒に関する基礎研究とその臨機応用 (2009)
  • Author(s): 館正弘
  • Journal Title: 日本創傷・オストミー・失禁管理学会誌 13(2) Pages: 2-7
• [Presentation] 糖尿病性足壊疸に対する最新の形成外科治療 (2010)
  • Author(s): 館正弘
  • Organizer: 第8回総合診療フォーラム
  • Place of Presentation: 仙台市フォレスト仙台
  • Year and Date: 2010-12-11
• [Presentation] 創傷治癒に対する物理療法の効果 (2010)
  • Author(s): 館正弘
  • Organizer: 第45回理学療法学術集会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-05-27
• [Presentation] 創傷治癒に関する基礎研究とその臨床応用 (2009)
  • Author(s): 館正弘
  • Organizer: 第18回日本創傷・オストミー・失禁ケア研究会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-05-09
• [Remarks] ホームページ等
  • URL: http://www.prs.med.tohoku.ac.jp
• [Remarks]
  • URL: http://prs.main.jp/