| Project/Area Number |
20592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
ICHINOSE Akihiro (2009-2010) Kobe University, 医学部附属病院, 准教授 (90362780)
永田 育子 (2008) Kobe University, 医学部附属病院, 臨床研究員 (20444599)
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| Co-Investigator(Kenkyū-buntansha) |
TAHARA Shinya (ISHIKAWA Yukio) 神戸大学, 医学部附属病院, 教授 (30276894)
田原 真也 神戸大学, 医学部附属病院, 教授 (60207206)
一瀬 晃洋 神戸大学, 医学部附属病院, 特命准教授 (90362780)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脈管奇形 / 血管内皮細胞 / リンパ管内皮細胞 / LYVE-1抗体 / 免疫組織化学 |
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| Research Abstract |
Immunohistochemical examinations were performed on the morbid vessels of vascular malformations using bountiful immunohistochemical markers of vascular endothelial cells including LYVE-1 antibodies, which we had recently developed. This study demonstrated that various patterns of immunohistochemical markers were expressed in vascular malformations which could be classified in the same category of vascular malformations such as either lymphatic vessel malformations or venous malformations. This suggests that they follow a different pathogenesis. In addition, the immunohistochemical method has made it easier to properly diagnosis the pathology of various microvessels. It has been demonstrated that this method is useful for accurate diagnosis of microinvasion into the small lymph vessels during the early stages of gastroenterological carcinoma and in determining the proper management of coronary disorders.
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