The development of cartilage regeneration methods using the human auricular cartilage progenitor cells in craniofacial deformity.
| Project/Area Number |
20592101
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KOBAYASHI Shinji Yokohama City University, 医学研究科, 客員研究員 (90464536)
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| Co-Investigator(Renkei-kenkyūsha) |
MAEGAWA Jirou 横浜市立大学, 附属病院, 准教授 (70244449)
TANIGUCHI Hideki 横浜市立大学, 医学研究科, 教授 (70292555)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 再生医学 / 軟骨膜細胞 / 軟骨前駆細胞 / 軟骨再生 / 軟骨膜 / ヒト耳介弾性軟骨 / 間葉系前駆細胞 / 耳介軟骨 |
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| Research Abstract |
Human cartilage progenitor cells(hCPCs), which were isolated from auricular perichondrium had not only high proliferative and multipotent capacity that human condrocytes(hCs) did not have, but had same cartilage extracellular matrix capacity as hCs. Furthermore, in vivo hCPCs formed the cartilage with perichondrium as normal auricular cartilage. The hCPCs with hydroxyapatite/chondroitin sulfate composite also formed larger cartilage in vivo.
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Report
(4 results)
Research Products
(8 results)
