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The development of cartilage regeneration methods using the human auricular cartilage progenitor cells in craniofacial deformity.

Research Project

Project/Area Number 20592101
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionYokohama City University

Principal Investigator

KOBAYASHI Shinji  Yokohama City University, 医学研究科, 客員研究員 (90464536)

Co-Investigator(Renkei-kenkyūsha) MAEGAWA Jirou  横浜市立大学, 附属病院, 准教授 (70244449)
TANIGUCHI Hideki  横浜市立大学, 医学研究科, 教授 (70292555)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords再生医学 / 軟骨膜細胞 / 軟骨前駆細胞 / 軟骨再生 / 軟骨膜 / ヒト耳介弾性軟骨 / 間葉系前駆細胞 / 耳介軟骨
Research Abstract

Human cartilage progenitor cells(hCPCs), which were isolated from auricular perichondrium had not only high proliferative and multipotent capacity that human condrocytes(hCs) did not have, but had same cartilage extracellular matrix capacity as hCs. Furthermore, in vivo hCPCs formed the cartilage with perichondrium as normal auricular cartilage. The hCPCs with hydroxyapatite/chondroitin sulfate composite also formed larger cartilage in vivo.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010 2009 2008

All Journal Article (2 results) Presentation (6 results)

  • [Journal Article] ヒト耳介弾性軟骨間葉系前駆細胞の特性解析2010

    • Author(s)
      小林眞司、谷口英樹
    • Journal Title

      MATERIALS INTEGRATION 23(2)

      Pages: 43-48

    • Related Report
      2010 Final Research Report
  • [Journal Article] ヒト耳介弾性軟骨間葉系前駆細胞の特性解析2010

    • Author(s)
      小林眞司
    • Journal Title

      MATERIALS INTEGRATION

      Volume: 23巻 Pages: 1024-1028

    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト耳介由来の弾性軟骨前駆細胞を用いた軟骨再生療法の開発2011

    • Author(s)
      小林眞司
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト耳介由来の弾性軟骨前駆細胞を用いた軟骨再生療法の開発2011

    • Author(s)
      小林眞司、武部貴則、管博臣、水野満、矢吹丈一郎、岩井さやか、乾翠、鄭允文、上野康晴、前川二郎、谷口英樹
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒト耳介弾性軟骨幹/前駆細胞の硝子軟骨組織への分化2009

    • Author(s)
      小林眞司、武部貴則、菅博臣、鄭允文、上野康晴、前川二郎、谷口英樹
    • Organizer
      第18回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 外耳軟骨膜に存在するヒト間葉系前駆細胞の分離・同定2008

    • Author(s)
      武部貴則 小林眞司 前川二郎谷口英樹
    • Organizer
      第6回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒト耳介軟骨膜細胞の細胞表面マーカーによる特性解析2008

    • Author(s)
      小林眞司、武部貴則、菅博臣、鄭允文、上野康晴、前川二郎、谷口英樹
    • Organizer
      第17回日本形成外科学会基礎学術集会
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] 外耳軟骨膜に存在するヒト間葉系前駆細胞の分離・同定2008

    • Author(s)
      武部貴則、小林眞司、前川二郎、谷口英樹
    • Organizer
      第6回幹細胞シンポジウム
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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