| Project/Area Number |
20592104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
NAKATSUKA Takashi Saitama Medical University, 医学部, 教授 (80198134)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHI Kazuto 東京大学, 医学部附属病院, 特任准教授 (30344451)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIOKA Higeru 埼玉医科大学, 医学部, 教授 (60306272)
TOKIOKA Kazuyuki 埼玉医科大学, 医学部, 准教授 (70332616)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 再生医学 / 移植 / 再生医療 / アポトーシス / 軟骨再生 / 軟骨膜 / 虚血 / P53 / 移植・再生医療 / 再生軟骨 |
|---|
| Research Abstract |
It is assumed that the functions of the surrounding perichondrium-like tissues are important for cartilage regeneration. The purpose of this study was to explicate the effects of the blood circulation in the perichondrium-like tissues on cartilage regeneration and to provide the information on the development of the maintenance of regenerative cartilage. We conducted the assessments of the effects of anoxic stress on regenerative cartilage, using p53 knockout mice. As results, it was suggested that the blood circulation around the regenerative tissues influenced cartilage regeneration and the blood supply to transplants was an important factor for in vivo metabolism and maintenance of their shape.
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