Therapeutic Angiogenesis with oxygen application new biomaterials for chronic wounds
Project/Area Number |
20592105
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Plastic surgery
|
Research Institution | Saitama Medical University |
Principal Investigator |
ICHIOKA Shigeru Saitama Medical University, 医学部, 教授 (60306272)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 創傷治癒 / 再生医学 / 創傷治癒学 |
Research Abstract |
Optimal oxygen environment for wound healing is still unknown. The study aims to experimentally evaluate the wound healing dynamics under different oxygen environment. We applied an oxygen non-permeable membrane (Polyvinylidene chloride, oxygen permeability : 40-90ml/m2・24hr・1atm) and an oxygen permeable membrane (Polymethylpentene, oxygen permeability : 60000-65000ml/m2・24hr・1atm) to excisional skin defects in ddy mice Our result suggested that sufficient oxygen allowed adequate epithelialization and granulation formation. Enhanced neovascularization in the non-permeable group likely implies compensation of hypoxic condition.
|
Report
(4 results)
Research Products
(34 results)