| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Optimal oxygen environment for wound healing is still unknown.
The study aims to experimentally evaluate the wound healing dynamics under different oxygen environment.
We applied an oxygen non-permeable membrane (Polyvinylidene chloride, oxygen permeability : 40-90ml/m2・24hr・1atm) and an oxygen permeable membrane (Polymethylpentene, oxygen permeability : 60000-65000ml/m2・24hr・1atm) to excisional skin defects in ddy mice
Our result suggested that sufficient oxygen allowed adequate epithelialization and granulation formation. Enhanced neovascularization in the non-permeable group likely implies compensation of hypoxic condition.
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