Roles of cytoskeletal proteins in organic fibrosis and their application of therapy in fibrotic diseases
Project/Area Number |
20592111
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Plastic surgery
|
Research Institution | Kinki University |
Principal Investigator |
YOSHIDA Koji Kinki University, 医学部, 准教授 (60230736)
|
Co-Investigator(Kenkyū-buntansha) |
SAITO Akio 近畿大学, 医学部, 講師 (40153788)
HAGIHARA Satoru 近畿大学, 医学部, 講師 (40460852)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 線維化 / 線維芽細胞 / transgelin / integrin α11 / CIB1 / インテグリン / integrin / fibronectin / CTGF / 創傷治癒 / two-hybrid / shRNA / TGF-β |
Research Abstract |
Activation of myofibroblasts was inhibited when the expression of transgelin was knocked down. When human lung fibroblasts were stimulated by TGF-β, the integrin α11 (ITGA11) expression was markedly increased. Calcium and integrin binding protein 1 (CIB1) bound to the intracellular domain of ITGA11. The expression of CIB1 increased in human lung fibroblasts treated with TGF-β and in bleomycin-treated mice pulmonary tissues. These results suggest that CIB1 may be involved in the fibrosis.
|
Report
(4 results)
Research Products
(14 results)