Novel Aldosterone thereutic strategy for severe sepsis treatmnet

• Project/Area Number: 20592114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Tohoku University
• Principal Investigator: EJIMA Yutaka Tohoku University, 病院, 講師 (90301051)
• Co-Investigator(Kenkyū-buntansha): TOYAMA Hiroaki 東北大学, 病院, 助教 (00375007) ; MATSUBARA Mitsunobu 東北大学, 大学院・医学系・研究科, 准教授 (30282073)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 敗血症 / アルドステロン

Research Abstract

Adrenalectomized sepsis rat supplemented with only glucocorticoid or mineralocorticoid could not survive. We thought that the existence of both corticoids has specific effective effect on adrenalectomized sepsis rat living.