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Expression of a lipid-metabolizing enzyme, diacylglycerol kinase, after brain damage

Research Project

Project/Area Number 20592116
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionYamagata University

Principal Investigator

KAWAMAE Kaneyuki  山形大学, 医学部, 教授 (70254026)

Co-Investigator(Kenkyū-buntansha) GOTO Kaoru  山形大学, 医学部, 教授 (30234975)
ISEKI Ken  山形大学, 医学部, 准教授 (70332921)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳損傷 / 脂質代謝酵素 / ミクログリア / グリア細胞 / リモデリング / KOマウス / 脂質代謝 / 神経細胞 / 核
Research Abstract

Diacyglycerol kinase (DGK) plays an important role in the intracellular signal transduction through the metabolism of a second messenger diacylglycerol. One of the DGK isozymes, DGKζ was originally shown to be expressed in neurons under physiological conditions. However, we found that under pathological conditions, a cryoinjury brain model, DGKζ-immunoreactivity is detected in activated microglia that phagocytose the debris after brain injury. These results suggest that DGK. participates in the remodeling of the brain after injury.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (37 results)

All 2011 2010 2009 2008

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (16 results)

  • [Journal Article] NAP Interaction of nucleosome assembly proteins abolishes nuclear localization of DGKζ by attenuating its association with importins2011

    • Author(s)
      Okada M, Hozumi Y, Ichimura T, Tanaka T, Hasegawa H, Yamamoto M, Takahashi N, Iseki K, Yagisawa H, Shinkawa T, Isobe T, Goto K
    • Journal Title

      Exp Cell Res

      Volume: 317 Pages: 2853-63

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excitotoxicity by kainate-induced seizure causes diacylglycerol kinase ζ to shuttle from the nucleus to the cytoplasm in hippocampal neurons2011

    • Author(s)
      Saino-S S, Hozumi Y, Goto K
    • Journal Title

      Neurosci Lett

      Volume: 494 Pages: 185-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered expression pattern of testican-1 mRNA after brain injury2011

    • Author(s)
      Iseki K, Hagino H, Zhang Y, Mori T, Sato N, Yokoya S, Hozumi Y, Goto K, Tase C
    • Journal Title

      Biomed Res

      Volume: 32 Pages: 373-8

    • NAID

      130004470790

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 集中治療室における危機管理体制の現状-全国調査2011

    • Author(s)
      川前金幸, 鮎川勝彦, 内野博之, 中敏夫, 西田修, 成松英智, 池田寿昭
    • Journal Title

      日本集中治療医学会

      Volume: 18 Pages: 116-25

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Tohoku ALI Study Group. A prospective cohort study of ALI/ARDS in the Tohoku district of Japan (second report)2010

    • Author(s)
      Endo S, Shibata S, Sato N, Hashiba E, Tajjimi K, Saito K, Kawamae K, Nakane M, Murakawa M
    • Journal Title

      J Anesth

      Volume: 24 Pages: 351-358

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a functional nuclear export sequence in diacylglycerol kinase2010

    • Author(s)
      Evangelisti C, Gaboardi GC, Billi AM, Ognibene A, Goto K, Tazzari PL, McCubrey JA, Martelli AM
    • Journal Title

      Cell Cycle

      Volume: 9 Pages: 1-6

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 手術中に覚醒を必要とする脳神経外科手術(awake craniotomy)の麻酔管理におけるレミフェンタニルの有効性2010

    • Author(s)
      岡田真行, 高田康輔, 川前金幸
    • Journal Title

      麻酔

      Volume: 59 Pages: 75-81

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] アナフィラキシーショックの治療にβ遮断薬が影響を及ぼした心肺停止に陥った1症例2010

    • Author(s)
      永野達也, 伊関憲, 仁木敬夫, 杉浦明日美, 二藤部丈司, 川前金幸
    • Journal Title

      日本集中治療医学会雑誌

      Volume: 17 Pages: 207-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Signaling Cascade of Diacylglycerol Kinase beta in the Pituitary Intermediate Lobe : Dopamine D2 Receptor/Phospholipase C-beta4/Diacylglycerol Kinase-beta/Protein Kinase C-alpha2010

    • Author(s)
      Hozumi Y, et al.
    • Journal Title

      J Histochem Cytochem

      Volume: 58 Pages: 119-129

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a functional nuclear export sequence in diacylglycerol kinase-zeta2010

    • Author(s)
      Evangelisti C, et al.
    • Journal Title

      Cell Cycle

      Volume: 9 Pages: 1-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain traume induces ex-pression of diacylglycerol kinase ζ in microglia2009

    • Author(s)
      Nakano T, Iseki K, Hozumi Y, Kawamae K, Wakabayashi I, Goto K
    • Journal Title

      Neurosci Lett

      Volume: 46 Pages: 110-115

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest2009

    • Author(s)
      Evangelisti C, Astolfi A, Gaboardi GC, Tazzari P, Pession A, Goto K, Martelli AM
    • Journal Title

      Cellular Signalling

      Volume: 21 Pages: 801-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 嫌酒者によるメタノール中毒の1例2009

    • Author(s)
      伊関憲, 永野達也, 杉浦明日美, 金井雅代, 仁木敬夫, 堀寧, 川前金幸
    • Journal Title

      中毒研究

      Volume: 22(3) Pages: 238-239

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain trauma induces expression of diacylglycerol kinase zeta in microglia2009

    • Author(s)
      Nakano T, Iseki K, Hozumi Y, Kawamae K, Wakabayashi I, Goto K.
    • Journal Title

      Neurosci Lett. 461

      Pages: 110-115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons2009

    • Author(s)
      Hozumi, et al.
    • Journal Title

      BMC Neurosci. 10

      Pages: 99-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of diacylglycerol kinase epsilon on stress fibers in vaseular smooth muscle cells2009

    • Author(s)
      Nakano, et al.
    • Journal Title

      Cell Tissue Res. 337

      Pages: 167-175

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase ζ is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells2008

    • Author(s)
      Hasegawa H, Nakano T, Hozumi Y, Takagi M, Ogino T, Okada M, Iseki K, Kondo H, Watanabe M, Martelli AM, Goto K
    • Journal Title

      J Cell Biochem

      Volume: 105 Pages: 756-65

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 剖検により判明した心サルコイドーシスの1例2008

    • Author(s)
      大瀧恵, 伊関憲, 池谷龍一, 奥山志野, 永野達也, 山川光徳, 川前金幸
    • Journal Title

      日本救急医学会雑誌

      Volume: 19 Pages: 229-234

    • NAID

      10024372179

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum2008

    • Author(s)
      Hozumi, et.al.
    • Journal Title

      Eur J Neurosci 28

      Pages: 2409-2422

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diacylglycerol kinase zeta is associated with chromatin, but dissociates from condensed chromatin during mitotic phase in NIH3T3 cells2008

    • Author(s)
      Hasegawa, et.al.
    • Journal Title

      J Cell Biochem 105

      Pages: 756-765

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipid messenger, diacylglycerol, and its regulator, diacylglycerol kinase, in cells, organs, and animals : history and perspective2008

    • Author(s)
      Goto et.al.
    • Journal Title

      Tohoku J Exp Med 214

      Pages: 199-212

    • NAID

      10024167082

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] ジアシルグリセロールキナーゼの細胞内局在の制御機構2010

    • Author(s)
      後藤薫
    • Organizer
      第5回DGK研究会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inspiratory Trigger and Expiratory Termination Sensitivity of New Anesthesia Ventilators2010

    • Author(s)
      Nakane M, Kurita S, Takahashi N, Yoshioka J, Oda S, Kawamae K
    • Organizer
      American Society of Anesthesiologists annual congress 2010
    • Place of Presentation
      San Diego
    • Related Report
      2010 Final Research Report
  • [Presentation] 日本集中治療医学会危機管理委員会:各施設の集中治療部における危機管理体制の現状2010

    • Author(s)
      川前金幸, 鮎川勝彦, 内野博之, 中敏夫, 西田修, 成松英智, 池田寿昭
    • Organizer
      第37回日本集中治療医学会
    • Place of Presentation
      広島
    • Related Report
      2010 Final Research Report
  • [Presentation] Nuclear assembly proteinはDGKζの細胞内局在を制御する2010

    • Author(s)
      岡田雅司, 後藤薫
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] DNA損傷におけるジアシルグリセロールキナーゼζとp53の役割2010

    • Author(s)
      田中俊昭, 後藤薫
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 無酸素無グルコース負荷(OGD)によるζ型ジアシルグリセロールキナーゼの細胞内局在の変化:海馬スライスを用いた検討2010

    • Author(s)
      鈴木祐輔, 後藤薫
    • Organizer
      第115回日本解剖学会総会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 細胞質局在型ジアシルグリセロールキナーゼξは細胞死を抑制する2010

    • Author(s)
      田中俊昭, ら
    • Organizer
      第56日本解剖学会・東北北海道地方会
    • Place of Presentation
      旭川
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cytoplasmic lipid kinase suppresses p53 stability2009

    • Author(s)
      Tanaka T, Okada M, Goto K
    • Organizer
      39th Annual Meeting of Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Nucleocytoplasmic translocation of diacylglycerol kinase zeta under oxygen and glucose deprivation in rat hippocampal slices2009

    • Author(s)
      Suzuki Y, Yamazaki Y, Kaneko K, Fujii S, Iseki K, Goto K
    • Organizer
      39th Annual Meeting of Neuroscience
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Upregulation of agrin in the reactive astrocytes after brain injury2009

    • Author(s)
      Iseki K, Goto K
    • Organizer
      9th European Meeting on Glial Cells in Health and Disease
    • Place of Presentation
      Paris, France
    • Related Report
      2010 Final Research Report
  • [Presentation] ジアシルグリセロールキナーゼの血管内皮細胞における発現解析2009

    • Author(s)
      中野知之, 若林一郎, 後藤薫
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] Nucleocytoplasmic translocation of diacylglycerol kinase zeta under oxygen and glucose deprivation in rat hippocampal slices2009

    • Author(s)
      Suzuki Y, Yamazaki Y, Kaneko K, Fujii S, Iseki K, Goto K.
    • Organizer
      39th Annual Meeting of Neuroscience
    • Place of Presentation
      Chicago
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞質局在型ジアシルグリセロールキナーゼζはp53の発現を抑制する2009

    • Author(s)
      田中俊昭、岡田雅司、後藤薫
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression and subcellular localization of diacylglycerol kinase isozyme in rat aortic endothelial cells2008

    • Author(s)
      Nakano T, Goto K, Wakabayashi I
    • Organizer
      48th American Society for Cell Biology
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Diacylglycerol kinase β accumulates on the perisynaptic site of medium spiny neurons in the striatum2008

    • Author(s)
      Hozumi Y, Iseki K, Kawamae K, Goto K
    • Organizer
      38th Annual Meeting of Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Diacylglycerol kinase b accumulates on the perisynaptic site of medium spiny neurons in the striatum2008

    • Author(s)
      Yasukazu Hozumi, Ken Iseki, Kaneyuki Kawamae, Kaoru Goto
    • Organizer
      38th Annual Meeting of Neuroscience
    • Place of Presentation
      Washington D. C.
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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