Possibility of direct hemoper fusion using a new cytokine absorbing column

• Project/Area Number: 20592118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kanazawa University
• Principal Investigator: TANIGUCHI Takumi Kanazawa University, 医学系, 准教授 (30301196)
• Research Collaborator: KURITA Akihide 金沢大学, 医学系, 助教 (10507081)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血液浄化 / サイトカイン / ショック / 多臓器不全 / アシドーシス / 敗血症 / 急性呼吸不全

Research Abstract

Our previous study demonstrated that direct hemoperfusion using a new cytokine absorbing column (CTR treatment) reduced mortality and inhibited inflammatory responses in endotoxic-shock rats. The present research was performed to evaluate the effects of CTR treatment on hypercytokinemia induced by acute lung injury and hemorrhagic shock in rats. The present research demonstrated that the CTR treatment had beneficial effects on hypercytokinemia induced by acute lung injury and hemorrhagic shock in rats. These findings suggest that CTR treatment may be effective for the treatment of patients with hypercytokinemia.

Research Products

• [Journal Article] Effects of direct hemoperfusion using a cytokine adsorbing column on endotoxin-induced experimental acute lung injury in rats. (2010)
  • Author(s): 谷口巧, et al
  • Journal Title: Blood Purif 30 Pages: 44-49
  • Peer Reviewed
• [Journal Article] サイトカイン吸着カラムを用いた血液浄化療法の有用性. (2010)
  • Author(s): 谷口巧
  • Journal Title: ICUとCCU 34 Pages: 119-124
  • NAID: 10027445054
• [Journal Article] Effects of direct hemoperfusion using a cytokine adsorbing column on endotoxin-induced experimental acute lung injury in rats. (2010)
  • Author(s): Takumi Taniguchi, et al.
  • Journal Title: Blood Purif Volume: 30 Pages: 44-49
  • Peer Reviewed
• [Journal Article] Comparison of a cytokine adsorbing column and an endotoxin absorbing column for the treatment of experimental endotoxemia. (2009)
  • Author(s): Takumi Taniguchi, A Kurita, K Yamamoto, et al
  • Journal Title: Transfus Apher Sci 40 Pages: 55-59
  • Peer Reviewed
• [Journal Article] Comparison of a cytokine adsorbing column and an endotoxin a bsorbing column for the treatment of experimental endotoxemia. (2009)
  • Author(s): Takumi Taniguchi, et al
  • Journal Title: Transfusion and Apheresis Science 40 Pages: 55-59
  • Peer Reviewed
• [Presentation] 多臓器不全に対するサイトカイン吸着療法の有用性、(シンポジスト) (2010)
  • Author(s): 谷口巧
  • Organizer: 第21回日本急性血液浄化学会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2010-10-23
• [Presentation] 多臓器不全に対するサイトカイン吸着療法の有用性 (2010)
  • Author(s): 谷口巧
  • Organizer: 第21回日本急性血液浄化学会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-10-23
• [Presentation] 急性呼吸不全に対してのサイトカイン吸着療法の可能性(シンポジスト) (2010)
  • Author(s): 谷口巧
  • Organizer: 第37回日本集中治療医学会学術総会
  • Place of Presentation: 広島市民会館(広島)
  • Year and Date: 2010-03-06
• [Presentation] 急性呼吸不全に対してのサイトカイン吸着療法の可能性 (2010)
  • Author(s): 谷口巧
  • Organizer: 第37回日本集中治療医学会学術総会
  • Place of Presentation: 広島市民会館 (広島)
  • Year and Date: 2010-03-06
• [Presentation] Effects of cytokine absorbing therapy for endotoxin-induced experimental acute lung injury in rats. (2010)
  • Author(s): 谷口巧
  • Organizer: 10^<th> the joint scientific congress of the KSCCM and JSICM
  • Place of Presentation: Hiroshima City Hall (Hiroshima) (Japan)
  • Year and Date: 2010-03-05
• [Presentation] Effects of cytokine absorbing therapy for endotoxin-induced experimental acute lung injury in rats (2010)
  • Author(s): 谷口巧
  • Organizer: 10^<th> the joint scientific congress of the KSCCM and JSICM
  • Place of Presentation: Hiroshima City Hall (Hiroshima) (Japan)
  • Year and Date: 2010-03-05
• [Presentation] 急性呼吸不全に対するサイトカイン吸着カラムを用いた血液浄化療法の有用性 (2009)
  • Author(s): 谷口巧
  • Organizer: 第37回日本救急医学会総会
  • Place of Presentation: 盛岡市民文化ホール(岩手)
  • Year and Date: 2009-10-29
• [Presentation] 急性呼吸不全に対するサイトカイン吸着カラムを用いた血液浄化療法の有用性 (2009)
  • Author(s): 谷口巧
  • Organizer: 第37回日本救急医学会総会
  • Place of Presentation: 盛岡市民文化ホール (岩手)
  • Year and Date: 2009-10-29
• [Presentation] エンドトキシンショックモデルに対するサイトカイン吸着カラムを用いた血液浄化療法の有用性(シンポジスト) (2009)
  • Author(s): 谷口巧
  • Organizer: 第36回日本集中治療医学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2009-02-27
• [Presentation] エンドトキシンショックモデルに対するサイトカイン吸着カラムを用いた血液浄化療法の有用性 (2009)
  • Author(s): 谷口巧
  • Organizer: 第36回日本集中治療医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-27
• [Presentation] 急性呼吸不全モデルにおけるサイトカイン吸着カラムを用いた血液浄化療法の有用性 (2009)
  • Author(s): 谷口巧
  • Organizer: 第36回日本集中治療医学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-02-26
• [Presentation] Comparison of a cytokine adsorbed column and an endotoxin absorbed column for the treatment of experimental endotoxemia. (2009)
  • Author(s): 谷口巧
  • Organizer: 38^<th> Critical Care Medicine Meeting
  • Place of Presentation: Nashville(USA)
  • Year and Date: 2009-02-01
• [Presentation] The effects of direct hemoperfusion using a cytokine absorbing column for endotoxin-induced experimental acute lung injury in rats. (2009)
  • Author(s): 谷口巧
  • Organizer: 38^<th> Critical Care Medicine Meeting
  • Place of Presentation: Nashville(USA)
  • Year and Date: 2009-02-01
• [Presentation] Comparison of a cytokinc adsorbed column and an cndotoxin a bsorbed column for the treatment of experimental endotoxemia. (2009)
  • Author(s): Takumi Taniguchi
  • Organizer: 38^<th> Critical Care Medicine Meeting
  • Place of Presentation: Nashville (USA)
  • Year and Date: 2009-02-01
• [Presentation] The effects of direct hemoperfusion using a cytokine absorbing column for endotoxin-induced experimental acute lung injury in rats. (2009)
  • Author(s): Takumi Taniguchi
  • Organizer: 38^<th> Critical Care Medicine Meeting
  • Place of Presentation: Nashville (USA)
  • Year and Date: 2009-02-01
• [Presentation] エンドトキシンショックモデルに対するサイトカイン吸着カラムとエンドトキシン吸着カラムとを用いた際の効果の比較 (2008)
  • Author(s): 谷口巧
  • Organizer: 第36回日本救急医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-10-12
• [Book] Acute Blood Purification.(Basel, Karger)(vol 166)(Cytokine Adsorbing Columns. Suzuki H, Hirasawa H (eds)) (2010)
  • Author(s): Takumi Taniguchi
  • Publisher: Contrib Nephrol.